Motif ID: Dlx5_Dlx4

Z-value: 1.332

Transcription factors associated with Dlx5_Dlx4:

Gene SymbolEntrez IDGene Name
Dlx4 ENSMUSG00000020871.7 Dlx4
Dlx5 ENSMUSG00000029755.9 Dlx5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dlx5mm10_v2_chr6_-_6882068_68820920.271.3e-01Click!


Activity profile for motif Dlx5_Dlx4.

activity profile for motif Dlx5_Dlx4


Sorted Z-values histogram for motif Dlx5_Dlx4

Sorted Z-values for motif Dlx5_Dlx4



Network of associatons between targets according to the STRING database.



First level regulatory network of Dlx5_Dlx4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_84417359 9.238 ENSMUST00000113401.1
 Epha5
Eph receptor A5
chr11_+_58948890 5.667 ENSMUST00000078267.3
 Hist3h2ba
histone cluster 3, H2ba
chrM_+_10167 5.322 ENSMUST00000082414.1
 mt-Nd4
mitochondrially encoded NADH dehydrogenase 4
chr5_+_139543889 4.888 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr9_-_16378231 4.784 ENSMUST00000082170.5
 Fat3
FAT tumor suppressor homolog 3 (Drosophila)
chrM_+_9870 4.523 ENSMUST00000084013.1
 mt-Nd4l
mitochondrially encoded NADH dehydrogenase 4L
chrX_-_143933204 4.389 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chr5_+_17574268 4.306 ENSMUST00000030568.7
 Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr16_-_45724600 4.210 ENSMUST00000096057.4
 Tagln3
transgelin 3
chr3_+_55782500 3.947 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr1_-_24612700 3.754 ENSMUST00000088336.1
 Gm10222
predicted gene 10222
chr7_+_51621830 3.605 ENSMUST00000032710.5
 Slc17a6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chrX_-_143933089 3.385 ENSMUST00000087313.3
 Dcx
doublecortin
chr9_-_55919605 3.191 ENSMUST00000037408.8
 Scaper
S phase cyclin A-associated protein in the ER
chr9_-_66514567 3.042 ENSMUST00000056890.8
 Fbxl22
F-box and leucine-rich repeat protein 22
chr3_+_75557530 2.866 ENSMUST00000161776.1
ENSMUST00000029423.8
 Serpini1

serine (or cysteine) peptidase inhibitor, clade I, member 1

chr10_+_80264942 2.850 ENSMUST00000105362.1
ENSMUST00000105361.3
 Dazap1

DAZ associated protein 1

chr4_-_20778527 2.816 ENSMUST00000119374.1
 Nkain3
Na+/K+ transporting ATPase interacting 3
chr18_+_69346143 2.785 ENSMUST00000114980.1
 Tcf4
transcription factor 4
chr2_-_79456750 2.670 ENSMUST00000041099.4
 Neurod1
neurogenic differentiation 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 207 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 9.2 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.4 7.8 GO:0021860 pyramidal neuron development(GO:0021860)
0.4 6.7 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.9 6.5 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.7 6.0 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.2 5.2 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.2 5.0 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.1 4.7 GO:0006342 chromatin silencing(GO:0006342)
0.1 4.6 GO:0006334 nucleosome assembly(GO:0006334)
0.2 4.4 GO:0010842 retina layer formation(GO:0010842)
0.2 3.6 GO:0001504 neurotransmitter uptake(GO:0001504)
0.1 3.2 GO:0043010 camera-type eye development(GO:0043010)
0.1 3.1 GO:0007608 sensory perception of smell(GO:0007608)
0.0 3.0 GO:0002028 regulation of sodium ion transport(GO:0002028)
0.3 2.8 GO:0042118 endothelial cell activation(GO:0042118)
0.1 2.8 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.9 2.7 GO:0019085 early viral transcription(GO:0019085)
0.7 2.7 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.1 2.7 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.9 2.6 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 101 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 14.5 GO:0070469 respiratory chain(GO:0070469)
0.0 9.2 GO:0030425 dendrite(GO:0030425)
0.3 9.1 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 6.8 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 4.2 GO:0000790 nuclear chromatin(GO:0000790)
0.1 3.6 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 3.6 GO:0043198 dendritic shaft(GO:0043198)
0.0 3.4 GO:0031225 anchored component of membrane(GO:0031225)
0.0 3.3 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 3.3 GO:0098794 postsynapse(GO:0098794)
0.1 3.0 GO:0005844 polysome(GO:0005844)
0.0 2.7 GO:0043209 myelin sheath(GO:0043209)
0.1 2.5 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 2.5 GO:0031941 filamentous actin(GO:0031941)
0.1 2.4 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 2.4 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.4 2.2 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 2.2 GO:0043195 terminal bouton(GO:0043195)
0.0 2.2 GO:0036064 ciliary basal body(GO:0036064)
0.2 2.0 GO:0030122 AP-2 adaptor complex(GO:0030122)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 132 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 13.1 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
1.2 9.2 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.3 7.8 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.5 5.0 GO:0038191 neuropilin binding(GO:0038191)
0.1 4.9 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 4.1 GO:0042393 histone binding(GO:0042393)
0.0 3.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 3.4 GO:0061659 ubiquitin-like protein ligase activity(GO:0061659)
0.5 3.0 GO:0004984 olfactory receptor activity(GO:0004984)
0.2 2.9 GO:0035613 RNA stem-loop binding(GO:0035613)
0.7 2.8 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.2 2.8 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 2.7 GO:0031489 myosin V binding(GO:0031489)
0.1 2.6 GO:0001784 phosphotyrosine binding(GO:0001784)
0.6 2.5 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.8 2.3 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 2.3 GO:0019208 phosphatase regulator activity(GO:0019208)
0.7 2.2 GO:0001565 phorbol ester receptor activity(GO:0001565) non-kinase phorbol ester receptor activity(GO:0001566)
0.1 2.2 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.1 2.2 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)