Motif ID: E2f1

Z-value: 4.507


Transcription factors associated with E2f1:

Gene SymbolEntrez IDGene Name
E2f1 ENSMUSG00000027490.11 E2f1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f1mm10_v2_chr2_-_154569720_1545697990.722.8e-06Click!


Activity profile for motif E2f1.

activity profile for motif E2f1


Sorted Z-values histogram for motif E2f1

Sorted Z-values for motif E2f1



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_120476469 21.528 ENSMUST00000072777.7
ENSMUST00000159699.1
 Hmga2

high mobility group AT-hook 2

chr15_-_98004695 20.175 ENSMUST00000023123.8
 Col2a1
collagen, type II, alpha 1
chrX_-_60893430 18.376 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr15_-_98004634 17.906 ENSMUST00000131560.1
ENSMUST00000088355.5
 Col2a1

collagen, type II, alpha 1

chr12_+_8771317 17.472 ENSMUST00000020911.7
 Sdc1
syndecan 1
chr17_+_56303396 16.986 ENSMUST00000113038.1
 Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chrX_-_52613913 16.883 ENSMUST00000069360.7
 Gpc3
glypican 3
chrX_-_52613936 16.203 ENSMUST00000114857.1
 Gpc3
glypican 3
chr1_-_20820213 15.983 ENSMUST00000053266.9
 Mcm3
minichromosome maintenance deficient 3 (S. cerevisiae)
chr17_+_56303321 15.890 ENSMUST00000001258.8
 Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr12_+_8771405 15.564 ENSMUST00000171158.1
 Sdc1
syndecan 1
chr11_+_98907801 15.500 ENSMUST00000092706.6
 Cdc6
cell division cycle 6
chr11_+_119022962 14.780 ENSMUST00000026662.7
 Cbx2
chromobox 2
chr7_+_102441685 14.399 ENSMUST00000033283.9
 Rrm1
ribonucleotide reductase M1
chr16_+_93883895 14.183 ENSMUST00000023666.4
ENSMUST00000117099.1
ENSMUST00000142316.1
 Chaf1b


chromatin assembly factor 1, subunit B (p60)


chr12_+_24708241 14.128 ENSMUST00000020980.5
 Rrm2
ribonucleotide reductase M2
chr7_+_13278778 14.124 ENSMUST00000098814.4
ENSMUST00000146998.1
ENSMUST00000185145.1
 Lig1


ligase I, DNA, ATP-dependent


chrX_+_71556874 13.499 ENSMUST00000123100.1
 Hmgb3
high mobility group box 3
chr7_+_65862029 13.048 ENSMUST00000055576.5
ENSMUST00000098391.4
 Pcsk6

proprotein convertase subtilisin/kexin type 6

chr14_-_47276790 12.945 ENSMUST00000111792.1
ENSMUST00000111791.1
ENSMUST00000111790.1
 Wdhd1


WD repeat and HMG-box DNA binding protein 1



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 526 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.5 115.9 GO:0006270 DNA replication initiation(GO:0006270)
5.1 45.8 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
3.0 45.3 GO:0010216 maintenance of DNA methylation(GO:0010216)
2.6 38.7 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
11.0 33.1 GO:0072180 mesonephric duct development(GO:0072177) mesonephric duct morphogenesis(GO:0072180)
6.6 33.0 GO:1903553 positive regulation of extracellular exosome assembly(GO:1903553)
1.0 26.1 GO:0040034 regulation of development, heterochronic(GO:0040034)
2.1 23.0 GO:2000653 regulation of genetic imprinting(GO:2000653)
2.7 21.3 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.3 21.0 GO:0051225 spindle assembly(GO:0051225)
4.1 20.7 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
2.3 20.7 GO:0060613 fat pad development(GO:0060613)
0.4 19.9 GO:0010501 RNA secondary structure unwinding(GO:0010501)
6.6 19.7 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
3.9 19.5 GO:0045578 negative regulation of B cell differentiation(GO:0045578)
2.8 19.5 GO:0033567 DNA replication, Okazaki fragment processing(GO:0033567)
3.6 17.9 GO:0015705 iodide transport(GO:0015705)
3.4 17.1 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
1.9 17.1 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.1 16.7 GO:0006260 DNA replication(GO:0006260)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 252 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 186.9 GO:0005634 nucleus(GO:0005634)
5.4 81.5 GO:0042555 MCM complex(GO:0042555)
1.3 65.8 GO:0000791 euchromatin(GO:0000791)
0.1 48.6 GO:0005667 transcription factor complex(GO:0005667)
3.1 39.7 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.2 38.8 GO:0009897 external side of plasma membrane(GO:0009897)
0.2 37.6 GO:0000775 chromosome, centromeric region(GO:0000775)
7.5 37.5 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.1 36.4 GO:0005730 nucleolus(GO:0005730)
0.1 33.1 GO:0031012 extracellular matrix(GO:0031012)
0.1 30.8 GO:0005925 focal adhesion(GO:0005925)
0.8 25.9 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.3 25.2 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.4 24.5 GO:0005844 polysome(GO:0005844)
0.6 24.1 GO:0034707 chloride channel complex(GO:0034707)
2.3 22.7 GO:0000805 X chromosome(GO:0000805)
1.0 20.8 GO:0035098 ESC/E(Z) complex(GO:0035098)
6.8 20.3 GO:0033186 CAF-1 complex(GO:0033186)
0.9 20.1 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.3 20.1 GO:0005581 collagen trimer(GO:0005581)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 332 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 65.6 GO:0003678 DNA helicase activity(GO:0003678)
0.2 47.2 GO:0008022 protein C-terminus binding(GO:0008022)
0.3 43.0 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.9 38.6 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
12.7 38.1 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
2.5 38.1 GO:0048407 platelet-derived growth factor binding(GO:0048407)
7.5 37.5 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.5 34.7 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.2 34.2 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
1.0 28.0 GO:0017025 TBP-class protein binding(GO:0017025)
0.7 27.8 GO:0008536 Ran GTPase binding(GO:0008536)
2.4 26.7 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
1.0 26.0 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
2.3 25.8 GO:0003680 AT DNA binding(GO:0003680)
0.1 25.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.2 24.5 GO:0042393 histone binding(GO:0042393)
0.4 23.4 GO:0008186 ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
1.1 22.8 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.6 21.6 GO:0070063 RNA polymerase binding(GO:0070063)
0.9 19.8 GO:0042813 Wnt-activated receptor activity(GO:0042813)