Motif ID: E2f2_E2f5

Z-value: 2.790

Transcription factors associated with E2f2_E2f5:

Gene SymbolEntrez IDGene Name
E2f2 ENSMUSG00000018983.9 E2f2
E2f5 ENSMUSG00000027552.8 E2f5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f2mm10_v2_chr4_+_136172367_1361723950.876.0e-11Click!
E2f5mm10_v2_chr3_+_14578609_145786870.722.7e-06Click!


Activity profile for motif E2f2_E2f5.

activity profile for motif E2f2_E2f5


Sorted Z-values histogram for motif E2f2_E2f5

Sorted Z-values for motif E2f2_E2f5



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f2_E2f5

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_139543889 15.457 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr4_+_136172367 13.616 ENSMUST00000061721.5
 E2f2
E2F transcription factor 2
chr12_+_24708241 12.097 ENSMUST00000020980.5
 Rrm2
ribonucleotide reductase M2
chr8_+_75109528 11.849 ENSMUST00000164309.1
 Mcm5
minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
chr2_-_157204483 11.744 ENSMUST00000029170.7
 Rbl1
retinoblastoma-like 1 (p107)
chr17_+_56304313 11.386 ENSMUST00000113035.1
ENSMUST00000113039.2
ENSMUST00000142387.1
 Uhrf1


ubiquitin-like, containing PHD and RING finger domains, 1


chr13_-_24761440 11.035 ENSMUST00000176890.1
ENSMUST00000175689.1
 Gmnn

geminin

chr10_-_69352886 10.388 ENSMUST00000119827.1
ENSMUST00000020099.5
 Cdk1

cyclin-dependent kinase 1

chr13_-_24761861 10.163 ENSMUST00000006898.3
ENSMUST00000110382.2
 Gmnn

geminin

chr6_+_4747306 10.103 ENSMUST00000175823.1
ENSMUST00000176204.1
ENSMUST00000166678.1
 Peg10


paternally expressed 10


chr1_-_128359610 9.183 ENSMUST00000027601.4
 Mcm6
minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)
chr10_-_60219260 9.060 ENSMUST00000135158.2
 Chst3
carbohydrate (chondroitin 6/keratan) sulfotransferase 3
chr13_+_92354783 8.470 ENSMUST00000022218.4
 Dhfr
dihydrofolate reductase
chr15_-_9140374 8.274 ENSMUST00000096482.3
ENSMUST00000110585.2
 Skp2

S-phase kinase-associated protein 2 (p45)

chr1_-_20820213 8.173 ENSMUST00000053266.9
 Mcm3
minichromosome maintenance deficient 3 (S. cerevisiae)
chr2_+_119112793 8.149 ENSMUST00000140939.1
ENSMUST00000028795.3
 Rad51

RAD51 homolog

chr10_+_110745433 8.020 ENSMUST00000174857.1
ENSMUST00000073781.5
ENSMUST00000173471.1
ENSMUST00000173634.1
 E2f7



E2F transcription factor 7



chr12_-_69228167 7.358 ENSMUST00000021359.5
 Pole2
polymerase (DNA directed), epsilon 2 (p59 subunit)
chr7_-_137314394 7.341 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
 Ebf3



early B cell factor 3



chr10_-_5805412 7.131 ENSMUST00000019907.7
 Fbxo5
F-box protein 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 176 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 38.8 GO:0006270 DNA replication initiation(GO:0006270)
2.7 35.2 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
1.7 24.1 GO:0090308 regulation of methylation-dependent chromatin silencing(GO:0090308)
0.4 21.7 GO:0008156 negative regulation of DNA replication(GO:0008156)
2.8 19.7 GO:1990086 lens fiber cell apoptotic process(GO:1990086)
1.9 18.8 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
5.7 17.0 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
1.9 15.5 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
1.7 11.9 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.3 11.2 GO:0043550 regulation of lipid kinase activity(GO:0043550)
1.2 11.1 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.2 10.6 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
1.5 8.8 GO:0006287 base-excision repair, gap-filling(GO:0006287)
1.0 8.7 GO:0090166 Golgi disassembly(GO:0090166)
2.1 8.5 GO:0046655 glycine biosynthetic process(GO:0006545) folic acid metabolic process(GO:0046655)
1.0 8.3 GO:1902916 positive regulation of protein polyubiquitination(GO:1902916)
0.3 8.3 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
2.0 8.1 GO:0042276 error-prone translesion synthesis(GO:0042276)
1.0 8.0 GO:0033504 floor plate development(GO:0033504)
0.1 7.8 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 98 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.6 53.5 GO:0042555 MCM complex(GO:0042555)
0.1 43.3 GO:0005667 transcription factor complex(GO:0005667)
0.6 31.5 GO:0005657 replication fork(GO:0005657)
4.3 21.3 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0 16.5 GO:0005730 nucleolus(GO:0005730)
0.2 11.5 GO:0005876 spindle microtubule(GO:0005876)
2.3 11.3 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.1 8.3 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 7.4 GO:0000139 Golgi membrane(GO:0000139)
0.7 6.7 GO:0000800 lateral element(GO:0000800)
1.6 6.5 GO:0031298 replication fork protection complex(GO:0031298)
0.8 6.5 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
1.6 6.4 GO:0016012 sarcoglycan complex(GO:0016012)
1.2 6.1 GO:0035189 Rb-E2F complex(GO:0035189)
0.1 5.9 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.1 5.7 GO:0005871 kinesin complex(GO:0005871)
1.9 5.6 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.9 5.2 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 5.1 GO:0005681 spliceosomal complex(GO:0005681)
0.5 4.6 GO:0034709 methylosome(GO:0034709)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 127 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 34.7 GO:0001047 core promoter binding(GO:0001047)
0.5 32.9 GO:0003678 DNA helicase activity(GO:0003678)
3.1 24.8 GO:0003688 DNA replication origin binding(GO:0003688)
4.3 21.3 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.7 19.7 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.2 19.4 GO:0070491 repressing transcription factor binding(GO:0070491)
6.4 19.2 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
1.0 17.6 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 15.1 GO:0044212 transcription regulatory region DNA binding(GO:0044212)
2.0 11.9 GO:0010997 anaphase-promoting complex binding(GO:0010997)
1.7 11.7 GO:0000150 recombinase activity(GO:0000150)
0.6 10.4 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
2.3 9.1 GO:0034481 chondroitin sulfotransferase activity(GO:0034481)
2.8 8.5 GO:0051870 methotrexate binding(GO:0051870)
0.1 7.8 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 6.6 GO:0042393 histone binding(GO:0042393)
0.6 6.5 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.4 6.4 GO:0004844 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
0.5 6.1 GO:1990226 histone methyltransferase binding(GO:1990226)
0.0 5.8 GO:0005096 GTPase activator activity(GO:0005096)