Motif ID: E2f2_E2f5
Z-value: 2.790
Transcription factors associated with E2f2_E2f5:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| E2f2 | ENSMUSG00000018983.9 | E2f2 |
| E2f5 | ENSMUSG00000027552.8 | E2f5 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2f2 | mm10_v2_chr4_+_136172367_136172395 | 0.87 | 6.0e-11 | Click! |
| E2f5 | mm10_v2_chr3_+_14578609_14578687 | 0.72 | 2.7e-06 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.7 | 17.0 | GO:0032877 | positive regulation of DNA endoreduplication(GO:0032877) |
| 2.8 | 19.7 | GO:1990086 | lens fiber cell apoptotic process(GO:1990086) |
| 2.7 | 35.2 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 2.1 | 6.4 | GO:0006285 | base-excision repair, AP site formation(GO:0006285) |
| 2.1 | 8.5 | GO:0046655 | glycine biosynthetic process(GO:0006545) folic acid metabolic process(GO:0046655) |
| 2.0 | 8.1 | GO:0042276 | error-prone translesion synthesis(GO:0042276) |
| 1.9 | 15.5 | GO:0035726 | common myeloid progenitor cell proliferation(GO:0035726) |
| 1.9 | 18.8 | GO:0009186 | deoxyribonucleoside diphosphate metabolic process(GO:0009186) |
| 1.8 | 7.1 | GO:0007056 | spindle assembly involved in female meiosis(GO:0007056) |
| 1.7 | 24.1 | GO:0090308 | regulation of methylation-dependent chromatin silencing(GO:0090308) |
| 1.7 | 6.9 | GO:0098763 | mitotic cell cycle phase(GO:0098763) |
| 1.7 | 11.9 | GO:0033314 | mitotic DNA replication checkpoint(GO:0033314) |
| 1.7 | 6.6 | GO:0000076 | DNA replication checkpoint(GO:0000076) |
| 1.6 | 38.8 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 1.5 | 8.8 | GO:0006287 | base-excision repair, gap-filling(GO:0006287) |
| 1.3 | 6.5 | GO:0034421 | post-translational protein acetylation(GO:0034421) |
| 1.3 | 7.6 | GO:1902969 | mitotic DNA replication(GO:1902969) |
| 1.2 | 11.1 | GO:0030206 | chondroitin sulfate biosynthetic process(GO:0030206) |
| 1.1 | 3.4 | GO:0035622 | intrahepatic bile duct development(GO:0035622) cholangiocyte proliferation(GO:1990705) |
| 1.1 | 3.4 | GO:0035604 | orbitofrontal cortex development(GO:0021769) fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow(GO:0035602) fibroblast growth factor receptor signaling pathway involved in hemopoiesis(GO:0035603) fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow(GO:0035604) fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development(GO:0035607) coronal suture morphogenesis(GO:0060365) squamous basal epithelial stem cell differentiation involved in prostate gland acinus development(GO:0060529) |
| 1.1 | 7.7 | GO:0019985 | translesion synthesis(GO:0019985) |
| 1.0 | 8.3 | GO:1902916 | positive regulation of protein polyubiquitination(GO:1902916) |
| 1.0 | 8.0 | GO:0033504 | floor plate development(GO:0033504) |
| 1.0 | 5.9 | GO:0046602 | regulation of mitotic centrosome separation(GO:0046602) |
| 1.0 | 8.7 | GO:0090166 | Golgi disassembly(GO:0090166) |
| 0.9 | 2.6 | GO:0045819 | positive regulation of glycogen catabolic process(GO:0045819) |
| 0.8 | 2.5 | GO:0003278 | apoptotic process involved in heart morphogenesis(GO:0003278) |
| 0.8 | 2.3 | GO:0070318 | positive regulation of G0 to G1 transition(GO:0070318) |
| 0.7 | 3.6 | GO:0072488 | ammonium transmembrane transport(GO:0072488) |
| 0.7 | 2.7 | GO:0006297 | nucleotide-excision repair, DNA gap filling(GO:0006297) |
| 0.7 | 4.7 | GO:0070561 | vitamin D receptor signaling pathway(GO:0070561) |
| 0.7 | 2.0 | GO:0071139 | resolution of recombination intermediates(GO:0071139) |
| 0.7 | 2.6 | GO:1904694 | negative regulation of vascular smooth muscle contraction(GO:1904694) |
| 0.7 | 3.3 | GO:0000212 | meiotic spindle organization(GO:0000212) |
| 0.6 | 3.2 | GO:0070602 | regulation of centromeric sister chromatid cohesion(GO:0070602) |
| 0.6 | 2.5 | GO:0072369 | regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) |
| 0.6 | 3.1 | GO:0071947 | protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947) |
| 0.6 | 2.4 | GO:0048304 | positive regulation of isotype switching to IgG isotypes(GO:0048304) |
| 0.6 | 1.8 | GO:0003223 | ventricular compact myocardium morphogenesis(GO:0003223) |
| 0.6 | 3.6 | GO:0042148 | strand invasion(GO:0042148) |
| 0.6 | 2.3 | GO:0014835 | myoblast differentiation involved in skeletal muscle regeneration(GO:0014835) |
| 0.6 | 4.6 | GO:0016446 | somatic hypermutation of immunoglobulin genes(GO:0016446) |
| 0.5 | 6.0 | GO:0061032 | visceral serous pericardium development(GO:0061032) |
| 0.5 | 1.6 | GO:0002184 | cytoplasmic translational termination(GO:0002184) |
| 0.5 | 2.1 | GO:0060266 | negative regulation of respiratory burst involved in inflammatory response(GO:0060266) negative regulation of respiratory burst(GO:0060268) |
| 0.5 | 1.5 | GO:0018214 | peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214) |
| 0.5 | 1.4 | GO:0007341 | penetration of zona pellucida(GO:0007341) |
| 0.5 | 2.7 | GO:0097368 | establishment of Sertoli cell barrier(GO:0097368) |
| 0.5 | 0.9 | GO:0061074 | regulation of neural retina development(GO:0061074) |
| 0.4 | 1.8 | GO:0043415 | positive regulation of skeletal muscle tissue regeneration(GO:0043415) |
| 0.4 | 2.2 | GO:0007089 | traversing start control point of mitotic cell cycle(GO:0007089) |
| 0.4 | 6.1 | GO:1904816 | positive regulation of protein localization to chromosome, telomeric region(GO:1904816) |
| 0.4 | 0.4 | GO:0090403 | oxidative stress-induced premature senescence(GO:0090403) |
| 0.4 | 1.3 | GO:0031627 | telomeric loop formation(GO:0031627) |
| 0.4 | 2.1 | GO:0043137 | DNA replication, removal of RNA primer(GO:0043137) |
| 0.4 | 2.6 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 0.4 | 1.2 | GO:0071603 | endothelial cell-cell adhesion(GO:0071603) |
| 0.4 | 1.2 | GO:0031990 | mRNA export from nucleus in response to heat stress(GO:0031990) |
| 0.4 | 2.7 | GO:0001887 | selenium compound metabolic process(GO:0001887) |
| 0.4 | 3.4 | GO:0051574 | positive regulation of histone H3-K9 methylation(GO:0051574) |
| 0.4 | 1.9 | GO:2000348 | regulation of CD40 signaling pathway(GO:2000348) |
| 0.4 | 1.1 | GO:1901896 | positive regulation of calcium-transporting ATPase activity(GO:1901896) |
| 0.4 | 3.7 | GO:1901030 | positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901030) |
| 0.4 | 21.7 | GO:0008156 | negative regulation of DNA replication(GO:0008156) |
| 0.4 | 3.7 | GO:0036123 | histone H3-K9 dimethylation(GO:0036123) |
| 0.3 | 2.1 | GO:0031936 | negative regulation of chromatin silencing(GO:0031936) |
| 0.3 | 1.0 | GO:0036228 | protein targeting to nuclear inner membrane(GO:0036228) |
| 0.3 | 1.3 | GO:1903984 | positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984) |
| 0.3 | 8.3 | GO:0045662 | negative regulation of myoblast differentiation(GO:0045662) |
| 0.3 | 1.2 | GO:0046125 | pyrimidine deoxyribonucleoside metabolic process(GO:0046125) |
| 0.3 | 1.2 | GO:1904008 | response to monosodium glutamate(GO:1904008) cellular response to monosodium glutamate(GO:1904009) |
| 0.3 | 0.9 | GO:0048352 | neural plate mediolateral regionalization(GO:0021998) mesoderm structural organization(GO:0048338) paraxial mesoderm structural organization(GO:0048352) lateral mesodermal cell fate commitment(GO:0048372) lateral mesodermal cell fate specification(GO:0048377) regulation of lateral mesodermal cell fate specification(GO:0048378) |
| 0.3 | 3.0 | GO:0006298 | mismatch repair(GO:0006298) |
| 0.3 | 1.0 | GO:0060056 | mammary gland involution(GO:0060056) |
| 0.3 | 11.2 | GO:0043550 | regulation of lipid kinase activity(GO:0043550) |
| 0.3 | 0.8 | GO:0071929 | alpha-tubulin acetylation(GO:0071929) |
| 0.3 | 4.8 | GO:0043486 | histone exchange(GO:0043486) |
| 0.2 | 1.0 | GO:2001032 | regulation of double-strand break repair via nonhomologous end joining(GO:2001032) |
| 0.2 | 2.4 | GO:0008063 | Toll signaling pathway(GO:0008063) |
| 0.2 | 1.2 | GO:0033600 | negative regulation of mammary gland epithelial cell proliferation(GO:0033600) |
| 0.2 | 0.7 | GO:0019065 | receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509) |
| 0.2 | 2.9 | GO:0030238 | male sex determination(GO:0030238) |
| 0.2 | 0.7 | GO:0006597 | spermine biosynthetic process(GO:0006597) |
| 0.2 | 0.4 | GO:0033484 | nitric oxide homeostasis(GO:0033484) |
| 0.2 | 2.8 | GO:0045647 | negative regulation of erythrocyte differentiation(GO:0045647) |
| 0.2 | 0.8 | GO:2000346 | negative regulation of hepatocyte proliferation(GO:2000346) |
| 0.2 | 1.9 | GO:0048386 | positive regulation of retinoic acid receptor signaling pathway(GO:0048386) |
| 0.2 | 1.4 | GO:0034379 | very-low-density lipoprotein particle assembly(GO:0034379) |
| 0.2 | 0.8 | GO:0071169 | establishment of protein localization to chromatin(GO:0071169) |
| 0.2 | 0.6 | GO:0050859 | negative regulation of B cell receptor signaling pathway(GO:0050859) |
| 0.2 | 1.0 | GO:0035984 | response to trichostatin A(GO:0035983) cellular response to trichostatin A(GO:0035984) |
| 0.2 | 2.5 | GO:0001833 | inner cell mass cell proliferation(GO:0001833) |
| 0.2 | 2.7 | GO:0010388 | cullin deneddylation(GO:0010388) |
| 0.2 | 0.6 | GO:0060821 | inactivation of X chromosome by DNA methylation(GO:0060821) |
| 0.2 | 0.6 | GO:2000015 | regulation of determination of dorsal identity(GO:2000015) |
| 0.2 | 2.9 | GO:0042407 | cristae formation(GO:0042407) |
| 0.2 | 1.6 | GO:0018095 | protein polyglutamylation(GO:0018095) |
| 0.2 | 2.7 | GO:0071260 | cellular response to mechanical stimulus(GO:0071260) |
| 0.2 | 10.6 | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845) |
| 0.2 | 1.0 | GO:0009249 | protein lipoylation(GO:0009249) |
| 0.2 | 0.6 | GO:0070836 | caveola assembly(GO:0070836) |
| 0.2 | 2.0 | GO:0046628 | positive regulation of insulin receptor signaling pathway(GO:0046628) |
| 0.2 | 1.2 | GO:0035562 | negative regulation of chromatin binding(GO:0035562) |
| 0.2 | 3.6 | GO:0036342 | post-anal tail morphogenesis(GO:0036342) |
| 0.2 | 3.5 | GO:0040034 | regulation of development, heterochronic(GO:0040034) |
| 0.2 | 5.6 | GO:0032781 | positive regulation of ATPase activity(GO:0032781) |
| 0.1 | 2.3 | GO:0007095 | mitotic G2 DNA damage checkpoint(GO:0007095) mitotic G2/M transition checkpoint(GO:0044818) |
| 0.1 | 1.2 | GO:0061088 | sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088) |
| 0.1 | 1.4 | GO:0010225 | response to UV-C(GO:0010225) |
| 0.1 | 0.8 | GO:1902897 | regulation of postsynaptic density protein 95 clustering(GO:1902897) |
| 0.1 | 0.8 | GO:1904251 | regulation of bile acid metabolic process(GO:1904251) |
| 0.1 | 1.4 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.1 | 2.2 | GO:0006516 | glycoprotein catabolic process(GO:0006516) |
| 0.1 | 2.2 | GO:0007131 | reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825) |
| 0.1 | 2.5 | GO:0042753 | positive regulation of circadian rhythm(GO:0042753) |
| 0.1 | 0.5 | GO:0072697 | protein localization to cell cortex(GO:0072697) |
| 0.1 | 1.3 | GO:0034312 | diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512) sphingoid biosynthetic process(GO:0046520) |
| 0.1 | 1.3 | GO:0009143 | nucleoside triphosphate catabolic process(GO:0009143) |
| 0.1 | 2.2 | GO:0097150 | neuronal stem cell population maintenance(GO:0097150) |
| 0.1 | 0.5 | GO:0006983 | ER overload response(GO:0006983) |
| 0.1 | 2.2 | GO:0040037 | negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037) |
| 0.1 | 5.3 | GO:0000725 | double-strand break repair via homologous recombination(GO:0000724) recombinational repair(GO:0000725) |
| 0.1 | 1.2 | GO:0060628 | regulation of ER to Golgi vesicle-mediated transport(GO:0060628) |
| 0.1 | 1.8 | GO:0032094 | response to food(GO:0032094) |
| 0.1 | 0.3 | GO:0035928 | rRNA import into mitochondrion(GO:0035928) |
| 0.1 | 0.3 | GO:0090069 | regulation of ribosome biogenesis(GO:0090069) |
| 0.1 | 0.6 | GO:0016139 | glycoside catabolic process(GO:0016139) |
| 0.1 | 1.7 | GO:0006221 | pyrimidine nucleotide biosynthetic process(GO:0006221) |
| 0.1 | 0.8 | GO:0070574 | cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574) |
| 0.1 | 1.0 | GO:0048026 | positive regulation of mRNA splicing, via spliceosome(GO:0048026) |
| 0.1 | 2.9 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 0.1 | 1.0 | GO:0007130 | synaptonemal complex assembly(GO:0007130) |
| 0.1 | 0.4 | GO:0071557 | histone H3-K27 demethylation(GO:0071557) |
| 0.1 | 2.4 | GO:0060135 | maternal process involved in female pregnancy(GO:0060135) |
| 0.1 | 1.8 | GO:0021511 | spinal cord patterning(GO:0021511) |
| 0.1 | 2.5 | GO:0007548 | sex differentiation(GO:0007548) |
| 0.1 | 4.0 | GO:0043966 | histone H3 acetylation(GO:0043966) |
| 0.1 | 0.3 | GO:0044791 | modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791) negative regulation by host of viral genome replication(GO:0044828) positive regulation by host of viral genome replication(GO:0044829) COPII-coated vesicle budding(GO:0090114) |
| 0.1 | 0.8 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.1 | 0.9 | GO:0035493 | SNARE complex assembly(GO:0035493) |
| 0.1 | 0.7 | GO:0002021 | response to dietary excess(GO:0002021) |
| 0.1 | 0.2 | GO:0060923 | cardiac muscle cell fate commitment(GO:0060923) |
| 0.1 | 1.9 | GO:0034314 | Arp2/3 complex-mediated actin nucleation(GO:0034314) |
| 0.1 | 7.8 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
| 0.1 | 1.0 | GO:2000772 | regulation of cellular senescence(GO:2000772) |
| 0.1 | 0.6 | GO:0080009 | mRNA methylation(GO:0080009) |
| 0.0 | 1.1 | GO:0007020 | microtubule nucleation(GO:0007020) |
| 0.0 | 0.3 | GO:0006452 | translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905) |
| 0.0 | 3.1 | GO:0051225 | spindle assembly(GO:0051225) |
| 0.0 | 0.2 | GO:0007197 | gastric acid secretion(GO:0001696) adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207) |
| 0.0 | 0.1 | GO:0001193 | maintenance of transcriptional fidelity during DNA-templated transcription elongation(GO:0001192) maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter(GO:0001193) |
| 0.0 | 1.5 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.0 | 1.0 | GO:0006289 | nucleotide-excision repair(GO:0006289) |
| 0.0 | 0.5 | GO:0034389 | lipid particle organization(GO:0034389) |
| 0.0 | 1.3 | GO:0007569 | cell aging(GO:0007569) |
| 0.0 | 2.0 | GO:0061077 | chaperone-mediated protein folding(GO:0061077) |
| 0.0 | 1.8 | GO:0048511 | rhythmic process(GO:0048511) |
| 0.0 | 0.6 | GO:0016226 | iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163) |
| 0.0 | 0.8 | GO:0033962 | cytoplasmic mRNA processing body assembly(GO:0033962) |
| 0.0 | 1.2 | GO:0016925 | protein sumoylation(GO:0016925) |
| 0.0 | 0.9 | GO:0051028 | mRNA transport(GO:0051028) |
| 0.0 | 0.3 | GO:0000291 | nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291) |
| 0.0 | 1.6 | GO:0001885 | endothelial cell development(GO:0001885) |
| 0.0 | 0.4 | GO:0006103 | 2-oxoglutarate metabolic process(GO:0006103) |
| 0.0 | 1.5 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.0 | 0.3 | GO:0060134 | prepulse inhibition(GO:0060134) |
| 0.0 | 0.5 | GO:0007340 | acrosome reaction(GO:0007340) |
| 0.0 | 0.2 | GO:0003215 | cardiac right ventricle morphogenesis(GO:0003215) |
| 0.0 | 0.8 | GO:0006261 | DNA-dependent DNA replication(GO:0006261) |
| 0.0 | 0.1 | GO:0010216 | maintenance of DNA methylation(GO:0010216) |
| 0.0 | 1.6 | GO:0045860 | positive regulation of protein kinase activity(GO:0045860) |
| 0.0 | 0.4 | GO:0031047 | gene silencing by RNA(GO:0031047) |
| 0.0 | 1.8 | GO:0030010 | establishment of cell polarity(GO:0030010) |
| 0.0 | 0.6 | GO:0021510 | spinal cord development(GO:0021510) |
| 0.0 | 0.4 | GO:0050766 | positive regulation of phagocytosis(GO:0050766) |
| 0.0 | 0.2 | GO:0009303 | rRNA transcription(GO:0009303) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.3 | 21.3 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
| 3.6 | 53.5 | GO:0042555 | MCM complex(GO:0042555) |
| 2.3 | 11.3 | GO:0008622 | epsilon DNA polymerase complex(GO:0008622) |
| 1.9 | 5.6 | GO:0005658 | alpha DNA polymerase:primase complex(GO:0005658) |
| 1.6 | 6.5 | GO:0031298 | replication fork protection complex(GO:0031298) |
| 1.6 | 6.4 | GO:0016012 | sarcoglycan complex(GO:0016012) |
| 1.4 | 4.1 | GO:0000811 | GINS complex(GO:0000811) |
| 1.2 | 6.1 | GO:0035189 | Rb-E2F complex(GO:0035189) |
| 0.9 | 5.2 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 0.8 | 2.5 | GO:0070557 | PCNA-p21 complex(GO:0070557) |
| 0.8 | 2.4 | GO:0043625 | delta DNA polymerase complex(GO:0043625) |
| 0.8 | 6.5 | GO:0031390 | Ctf18 RFC-like complex(GO:0031390) |
| 0.7 | 2.2 | GO:0000785 | chromatin(GO:0000785) |
| 0.7 | 3.7 | GO:0033553 | rDNA heterochromatin(GO:0033553) |
| 0.7 | 6.7 | GO:0000800 | lateral element(GO:0000800) |
| 0.6 | 3.8 | GO:0070776 | H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776) |
| 0.6 | 31.5 | GO:0005657 | replication fork(GO:0005657) |
| 0.5 | 1.6 | GO:0018444 | translation release factor complex(GO:0018444) |
| 0.5 | 1.0 | GO:0000801 | central element(GO:0000801) |
| 0.5 | 4.6 | GO:0034709 | methylosome(GO:0034709) |
| 0.5 | 4.6 | GO:0031464 | Cul4A-RING E3 ubiquitin ligase complex(GO:0031464) |
| 0.4 | 3.1 | GO:0001673 | male germ cell nucleus(GO:0001673) |
| 0.4 | 3.1 | GO:0070652 | HAUS complex(GO:0070652) |
| 0.4 | 3.9 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 0.3 | 2.9 | GO:0061617 | MICOS complex(GO:0061617) |
| 0.3 | 0.8 | GO:0005785 | signal recognition particle receptor complex(GO:0005785) |
| 0.3 | 3.3 | GO:0043240 | Fanconi anaemia nuclear complex(GO:0043240) |
| 0.2 | 1.3 | GO:0070187 | telosome(GO:0070187) |
| 0.2 | 1.0 | GO:0044611 | nuclear pore inner ring(GO:0044611) |
| 0.2 | 11.5 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.2 | 0.6 | GO:0034673 | inhibin-betaglycan-ActRII complex(GO:0034673) |
| 0.2 | 1.1 | GO:0044530 | supraspliceosomal complex(GO:0044530) |
| 0.2 | 3.8 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.2 | 2.2 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.2 | 1.2 | GO:0005638 | lamin filament(GO:0005638) |
| 0.2 | 2.4 | GO:0035631 | CD40 receptor complex(GO:0035631) |
| 0.2 | 1.8 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.2 | 1.9 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.2 | 1.1 | GO:0030677 | nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681) |
| 0.1 | 2.0 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.1 | 1.9 | GO:0097470 | ribbon synapse(GO:0097470) |
| 0.1 | 1.4 | GO:0042582 | primary lysosome(GO:0005766) azurophil granule(GO:0042582) |
| 0.1 | 8.3 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.1 | 2.1 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.1 | 0.8 | GO:0005664 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 0.1 | 1.8 | GO:0005686 | U2 snRNP(GO:0005686) |
| 0.1 | 0.6 | GO:0001740 | Barr body(GO:0001740) |
| 0.1 | 1.6 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.1 | 43.3 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.1 | 2.4 | GO:0002102 | podosome(GO:0002102) |
| 0.1 | 2.3 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
| 0.1 | 5.7 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.1 | 0.3 | GO:0031251 | PAN complex(GO:0031251) |
| 0.1 | 0.5 | GO:0070876 | SOSS complex(GO:0070876) |
| 0.1 | 1.5 | GO:0001741 | XY body(GO:0001741) |
| 0.1 | 0.4 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
| 0.1 | 0.8 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.1 | 0.9 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
| 0.1 | 0.2 | GO:0001652 | granular component(GO:0001652) |
| 0.1 | 0.6 | GO:0036396 | MIS complex(GO:0036396) mRNA editing complex(GO:0045293) |
| 0.1 | 1.2 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 0.1 | 0.3 | GO:0001651 | dense fibrillar component(GO:0001651) |
| 0.1 | 2.7 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.1 | 4.5 | GO:0000922 | spindle pole(GO:0000922) |
| 0.1 | 2.7 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.1 | 3.3 | GO:0072686 | mitotic spindle(GO:0072686) |
| 0.1 | 2.2 | GO:0030665 | clathrin-coated vesicle membrane(GO:0030665) |
| 0.1 | 5.9 | GO:0045111 | intermediate filament cytoskeleton(GO:0045111) |
| 0.1 | 1.2 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
| 0.1 | 2.3 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.1 | 0.5 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
| 0.1 | 2.2 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.0 | 0.4 | GO:0031595 | nuclear proteasome complex(GO:0031595) |
| 0.0 | 0.4 | GO:0045252 | oxoglutarate dehydrogenase complex(GO:0045252) |
| 0.0 | 0.5 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.0 | 3.0 | GO:0000313 | organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761) |
| 0.0 | 2.9 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.0 | 1.1 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.0 | 0.4 | GO:0044666 | MLL3/4 complex(GO:0044666) |
| 0.0 | 1.3 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.0 | 3.0 | GO:0030175 | filopodium(GO:0030175) |
| 0.0 | 7.4 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.0 | 0.8 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 1.3 | GO:0031514 | motile cilium(GO:0031514) |
| 0.0 | 1.9 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 5.1 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 0.0 | 1.4 | GO:0005819 | spindle(GO:0005819) |
| 0.0 | 1.8 | GO:0005814 | centriole(GO:0005814) |
| 0.0 | 16.5 | GO:0005730 | nucleolus(GO:0005730) |
| 0.0 | 0.3 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.0 | 0.1 | GO:0045261 | mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261) |
| 0.0 | 0.2 | GO:0044232 | organelle membrane contact site(GO:0044232) |
| 0.0 | 0.6 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.0 | 0.8 | GO:0000794 | condensed nuclear chromosome(GO:0000794) |
| 0.0 | 1.5 | GO:0005901 | caveola(GO:0005901) |
| 0.0 | 3.4 | GO:0043235 | receptor complex(GO:0043235) |
| 0.0 | 0.6 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 0.0 | GO:1903349 | omegasome membrane(GO:1903349) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.4 | 19.2 | GO:0044729 | hemi-methylated DNA-binding(GO:0044729) |
| 4.3 | 21.3 | GO:0061731 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 3.1 | 24.8 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 2.8 | 8.5 | GO:0051870 | methotrexate binding(GO:0051870) |
| 2.3 | 9.1 | GO:0034481 | chondroitin sulfotransferase activity(GO:0034481) |
| 2.0 | 11.9 | GO:0010997 | anaphase-promoting complex binding(GO:0010997) |
| 1.7 | 11.7 | GO:0000150 | recombinase activity(GO:0000150) |
| 1.0 | 3.0 | GO:0032137 | guanine/thymine mispair binding(GO:0032137) |
| 1.0 | 17.6 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 1.0 | 3.9 | GO:0008297 | single-stranded DNA exodeoxyribonuclease activity(GO:0008297) double-stranded DNA exodeoxyribonuclease activity(GO:0008309) |
| 0.9 | 3.6 | GO:0008821 | crossover junction endodeoxyribonuclease activity(GO:0008821) |
| 0.9 | 2.6 | GO:0000402 | open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402) |
| 0.8 | 2.5 | GO:0030337 | DNA polymerase processivity factor activity(GO:0030337) |
| 0.8 | 3.3 | GO:0071987 | WD40-repeat domain binding(GO:0071987) |
| 0.8 | 2.4 | GO:0008296 | 3'-5'-exodeoxyribonuclease activity(GO:0008296) |
| 0.7 | 2.9 | GO:0045131 | pre-mRNA branch point binding(GO:0045131) |
| 0.7 | 19.7 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.7 | 2.1 | GO:0048256 | 5'-flap endonuclease activity(GO:0017108) flap endonuclease activity(GO:0048256) |
| 0.7 | 2.0 | GO:0050510 | N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510) |
| 0.7 | 2.0 | GO:0035402 | histone kinase activity (H3-T11 specific)(GO:0035402) |
| 0.6 | 10.4 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
| 0.6 | 3.1 | GO:1990380 | Lys48-specific deubiquitinase activity(GO:1990380) |
| 0.6 | 3.7 | GO:0046974 | histone methyltransferase activity (H3-K9 specific)(GO:0046974) |
| 0.6 | 5.4 | GO:0008517 | folic acid transporter activity(GO:0008517) |
| 0.6 | 6.5 | GO:0003689 | DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) |
| 0.5 | 3.2 | GO:0003910 | DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910) |
| 0.5 | 32.9 | GO:0003678 | DNA helicase activity(GO:0003678) |
| 0.5 | 6.1 | GO:1990226 | histone methyltransferase binding(GO:1990226) |
| 0.5 | 1.0 | GO:0000405 | bubble DNA binding(GO:0000405) |
| 0.5 | 5.5 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.4 | 2.2 | GO:0004430 | 1-phosphatidylinositol 4-kinase activity(GO:0004430) |
| 0.4 | 6.4 | GO:0004844 | uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506) |
| 0.4 | 2.5 | GO:1990829 | C-rich single-stranded DNA binding(GO:1990829) |
| 0.4 | 0.4 | GO:0016751 | S-succinyltransferase activity(GO:0016751) |
| 0.4 | 1.2 | GO:0071208 | histone pre-mRNA DCP binding(GO:0071208) |
| 0.4 | 2.7 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 0.4 | 2.3 | GO:0051525 | NFAT protein binding(GO:0051525) |
| 0.4 | 3.4 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 0.4 | 4.7 | GO:0043024 | ribosomal small subunit binding(GO:0043024) |
| 0.4 | 4.2 | GO:0070182 | DNA polymerase binding(GO:0070182) |
| 0.3 | 2.0 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.3 | 2.7 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 0.3 | 1.3 | GO:0017050 | sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050) |
| 0.3 | 1.2 | GO:0019136 | deoxynucleoside kinase activity(GO:0019136) |
| 0.3 | 1.4 | GO:0004563 | beta-N-acetylhexosaminidase activity(GO:0004563) |
| 0.3 | 1.3 | GO:0003691 | double-stranded telomeric DNA binding(GO:0003691) |
| 0.3 | 0.8 | GO:0010484 | H3 histone acetyltransferase activity(GO:0010484) |
| 0.2 | 2.2 | GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 0.2 | 19.4 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
| 0.2 | 1.2 | GO:0070330 | aromatase activity(GO:0070330) |
| 0.2 | 3.6 | GO:0008519 | ammonium transmembrane transporter activity(GO:0008519) |
| 0.2 | 1.0 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.2 | 0.8 | GO:0002151 | G-quadruplex RNA binding(GO:0002151) poly(G) binding(GO:0034046) |
| 0.2 | 3.4 | GO:0008599 | protein phosphatase type 1 regulator activity(GO:0008599) |
| 0.2 | 34.7 | GO:0001047 | core promoter binding(GO:0001047) |
| 0.2 | 3.7 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.2 | 2.4 | GO:0031386 | protein tag(GO:0031386) |
| 0.2 | 1.3 | GO:0047429 | nucleoside-triphosphate diphosphatase activity(GO:0047429) |
| 0.2 | 2.8 | GO:0070411 | I-SMAD binding(GO:0070411) |
| 0.2 | 1.6 | GO:0003747 | translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079) |
| 0.2 | 0.8 | GO:0031730 | CCR5 chemokine receptor binding(GO:0031730) |
| 0.2 | 0.8 | GO:0004594 | pantothenate kinase activity(GO:0004594) |
| 0.2 | 0.8 | GO:0005047 | signal recognition particle binding(GO:0005047) |
| 0.2 | 1.4 | GO:0000400 | four-way junction DNA binding(GO:0000400) |
| 0.2 | 1.1 | GO:1990446 | U1 snRNP binding(GO:1990446) |
| 0.2 | 2.6 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.1 | 0.9 | GO:0098821 | BMP receptor activity(GO:0098821) |
| 0.1 | 0.6 | GO:0051425 | PTB domain binding(GO:0051425) |
| 0.1 | 3.1 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
| 0.1 | 2.9 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 0.1 | 0.5 | GO:0035473 | lipase binding(GO:0035473) |
| 0.1 | 0.8 | GO:0052630 | CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity(GO:0043338) phospholactate guanylyltransferase activity(GO:0043814) ATP:coenzyme F420 adenylyltransferase activity(GO:0043910) UDP-N-acetylgalactosamine diphosphorylase activity(GO:0052630) |
| 0.1 | 1.5 | GO:0048038 | quinone binding(GO:0048038) |
| 0.1 | 4.6 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.1 | 1.8 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
| 0.1 | 0.8 | GO:0001055 | RNA polymerase II activity(GO:0001055) |
| 0.1 | 4.2 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.1 | 1.1 | GO:0004526 | ribonuclease P activity(GO:0004526) |
| 0.1 | 3.4 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.1 | 0.6 | GO:0005114 | type II transforming growth factor beta receptor binding(GO:0005114) |
| 0.1 | 2.8 | GO:0070888 | E-box binding(GO:0070888) |
| 0.1 | 3.1 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.1 | 5.7 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.1 | 0.2 | GO:0016934 | extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934) |
| 0.1 | 0.8 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.1 | 2.0 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.1 | 2.0 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.1 | 7.8 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.1 | 3.8 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.1 | 1.5 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.1 | 0.4 | GO:0036402 | proteasome-activating ATPase activity(GO:0036402) |
| 0.1 | 0.4 | GO:0071558 | histone demethylase activity (H3-K27 specific)(GO:0071558) |
| 0.1 | 1.4 | GO:0036002 | pre-mRNA binding(GO:0036002) |
| 0.1 | 1.0 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.1 | 1.8 | GO:0005160 | transforming growth factor beta receptor binding(GO:0005160) |
| 0.1 | 1.2 | GO:0008432 | JUN kinase binding(GO:0008432) |
| 0.0 | 2.3 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.0 | 3.0 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.0 | 1.9 | GO:0042974 | retinoic acid receptor binding(GO:0042974) |
| 0.0 | 1.6 | GO:0004772 | sterol O-acyltransferase activity(GO:0004772) |
| 0.0 | 0.9 | GO:0005112 | Notch binding(GO:0005112) |
| 0.0 | 6.6 | GO:0042393 | histone binding(GO:0042393) |
| 0.0 | 4.6 | GO:0004386 | helicase activity(GO:0004386) |
| 0.0 | 3.0 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 0.3 | GO:0004972 | NMDA glutamate receptor activity(GO:0004972) |
| 0.0 | 0.3 | GO:0008097 | 5S rRNA binding(GO:0008097) |
| 0.0 | 0.6 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.0 | 0.4 | GO:0005537 | mannose binding(GO:0005537) |
| 0.0 | 0.5 | GO:0034946 | 2-oxoglutaryl-CoA thioesterase activity(GO:0034843) 2,4,4-trimethyl-3-oxopentanoyl-CoA thioesterase activity(GO:0034869) 3-isopropylbut-3-enoyl-CoA thioesterase activity(GO:0034946) glutaryl-CoA hydrolase activity(GO:0044466) |
| 0.0 | 0.3 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 0.0 | 0.4 | GO:0043747 | protein-N-terminal asparagine amidohydrolase activity(GO:0008418) UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity(GO:0008759) iprodione amidohydrolase activity(GO:0018748) (3,5-dichlorophenylurea)acetate amidohydrolase activity(GO:0018749) 4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity(GO:0034571) didemethylisoproturon amidohydrolase activity(GO:0034573) N-isopropylacetanilide amidohydrolase activity(GO:0034576) N-cyclohexylformamide amidohydrolase activity(GO:0034781) isonicotinic acid hydrazide hydrolase activity(GO:0034876) cis-aconitamide amidase activity(GO:0034882) gamma-N-formylaminovinylacetate hydrolase activity(GO:0034885) N2-acetyl-L-lysine deacetylase activity(GO:0043747) O-succinylbenzoate synthase activity(GO:0043748) indoleacetamide hydrolase activity(GO:0043864) N-acetylcitrulline deacetylase activity(GO:0043909) N-acetylgalactosamine-6-phosphate deacetylase activity(GO:0047419) diacetylchitobiose deacetylase activity(GO:0052773) chitooligosaccharide deacetylase activity(GO:0052790) |
| 0.0 | 0.5 | GO:0016864 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
| 0.0 | 1.4 | GO:0008237 | metallopeptidase activity(GO:0008237) |
| 0.0 | 15.1 | GO:0044212 | transcription regulatory region DNA binding(GO:0044212) |
| 0.0 | 0.8 | GO:0045182 | translation regulator activity(GO:0045182) |
| 0.0 | 0.2 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.0 | 0.5 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
| 0.0 | 5.8 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 5.0 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.0 | 2.6 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.0 | 0.3 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.0 | 0.4 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.0 | 1.8 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.0 | 0.5 | GO:0048487 | beta-tubulin binding(GO:0048487) |
| 0.0 | 0.4 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.0 | 0.1 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.0 | 2.2 | GO:0043565 | sequence-specific DNA binding(GO:0043565) |
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