Motif ID: E2f3

Z-value: 0.868


Transcription factors associated with E2f3:

Gene SymbolEntrez IDGene Name
E2f3 ENSMUSG00000016477.11 E2f3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f3mm10_v2_chr13_-_29984219_299843530.373.6e-02Click!


Activity profile for motif E2f3.

activity profile for motif E2f3


Sorted Z-values histogram for motif E2f3

Sorted Z-values for motif E2f3



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_46450892 4.032 ENSMUST00000102926.4
 Anp32b
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr7_-_137314394 3.500 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
 Ebf3



early B cell factor 3



chrX_-_51205773 2.479 ENSMUST00000114875.1
 Mbnl3
muscleblind-like 3 (Drosophila)
chr5_+_114568016 1.973 ENSMUST00000043650.7
 Fam222a
family with sequence similarity 222, member A
chr5_-_100719675 1.948 ENSMUST00000112908.1
ENSMUST00000045617.8
 Hpse

heparanase

chr12_-_69228167 1.660 ENSMUST00000021359.5
 Pole2
polymerase (DNA directed), epsilon 2 (p59 subunit)
chr3_-_84155762 1.644 ENSMUST00000047368.6
 Mnd1
meiotic nuclear divisions 1 homolog (S. cerevisiae)
chr7_+_13278778 1.534 ENSMUST00000098814.4
ENSMUST00000146998.1
ENSMUST00000185145.1
 Lig1


ligase I, DNA, ATP-dependent


chrX_-_51205990 1.518 ENSMUST00000114876.2
 Mbnl3
muscleblind-like 3 (Drosophila)
chr19_+_41482632 1.474 ENSMUST00000067795.5
 Lcor
ligand dependent nuclear receptor corepressor
chr13_+_117220584 1.409 ENSMUST00000022242.7
 Emb
embigin
chr11_-_100759942 1.378 ENSMUST00000107363.2
 Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr16_-_4719078 1.332 ENSMUST00000120056.1
ENSMUST00000074970.7
 Nmral1

NmrA-like family domain containing 1

chr12_+_24708241 1.325 ENSMUST00000020980.5
 Rrm2
ribonucleotide reductase M2
chr16_-_4719148 1.309 ENSMUST00000115851.3
 Nmral1
NmrA-like family domain containing 1
chr17_+_35841668 1.206 ENSMUST00000174124.1
 Mdc1
mediator of DNA damage checkpoint 1
chr5_+_108132885 1.182 ENSMUST00000047677.7
 Ccdc18
coiled-coil domain containing 18
chrX_-_48454152 1.143 ENSMUST00000114958.1
 Elf4
E74-like factor 4 (ets domain transcription factor)
chr10_+_50895651 1.122 ENSMUST00000020071.3
 Sim1
single-minded homolog 1 (Drosophila)
chr18_+_11657349 1.116 ENSMUST00000047322.6
 Rbbp8
retinoblastoma binding protein 8

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 108 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.5 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.1 4.0 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.2 2.4 GO:1902969 mitotic DNA replication(GO:1902969)
0.6 1.9 GO:0030167 proteoglycan catabolic process(GO:0030167)
0.4 1.8 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.4 1.7 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.0 1.5 GO:0046677 response to antibiotic(GO:0046677)
0.1 1.4 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.1 1.3 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.4 1.1 GO:0001866 NK T cell proliferation(GO:0001866)
0.2 1.1 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.1 1.1 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 1.1 GO:0010574 regulation of vascular endothelial growth factor production(GO:0010574)
0.3 1.0 GO:0010752 negative regulation of antigen processing and presentation(GO:0002578) negative regulation of nitric oxide mediated signal transduction(GO:0010751) regulation of cGMP-mediated signaling(GO:0010752) negative regulation of plasminogen activation(GO:0010757)
0.2 1.0 GO:0097393 post-embryonic appendage morphogenesis(GO:0035120) post-embryonic limb morphogenesis(GO:0035127) post-embryonic forelimb morphogenesis(GO:0035128) telomeric repeat-containing RNA transcription(GO:0097393) telomeric repeat-containing RNA transcription from RNA pol II promoter(GO:0097394) regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901580) negative regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901581) positive regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901582)
0.2 1.0 GO:0071033 nuclear retention of pre-mRNA at the site of transcription(GO:0071033) CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043) polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.1 1.0 GO:0048478 replication fork protection(GO:0048478)
0.1 1.0 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.1 1.0 GO:1901970 positive regulation of mitotic sister chromatid separation(GO:1901970)
0.0 1.0 GO:0048246 macrophage chemotaxis(GO:0048246)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 2.8 GO:0000796 condensin complex(GO:0000796)
0.0 2.1 GO:0016605 PML body(GO:0016605)
0.0 1.8 GO:0016607 nuclear speck(GO:0016607)
0.3 1.7 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.1 1.4 GO:1990023 mitotic spindle midzone(GO:1990023)
0.3 1.3 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.2 1.3 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 1.2 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.2 1.1 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.1 1.1 GO:0016580 Sin3 complex(GO:0016580)
0.0 1.1 GO:0016592 mediator complex(GO:0016592)
0.0 1.1 GO:0017053 transcriptional repressor complex(GO:0017053)
0.3 1.0 GO:0005577 fibrinogen complex(GO:0005577)
0.2 1.0 GO:1990421 subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707)
0.1 1.0 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 1.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 1.0 GO:0072686 mitotic spindle(GO:0072686)
0.3 0.9 GO:0000811 GINS complex(GO:0000811)
0.0 0.9 GO:0005814 centriole(GO:0005814)
0.1 0.8 GO:0071439 clathrin complex(GO:0071439)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.9 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 2.4 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.6 1.9 GO:0004566 beta-glucuronidase activity(GO:0004566)
0.1 1.7 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.3 1.5 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0 1.5 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.3 1.3 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.1 1.3 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.2 1.2 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 1.1 GO:0008536 Ran GTPase binding(GO:0008536)
0.3 1.0 GO:0070052 collagen V binding(GO:0070052)
0.2 1.0 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.1 1.0 GO:0015616 DNA translocase activity(GO:0015616)
0.0 1.0 GO:0003684 damaged DNA binding(GO:0003684)
0.0 1.0 GO:0019843 rRNA binding(GO:0019843)
0.1 0.9 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.0 0.9 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.9 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 0.8 GO:0051010 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) microtubule plus-end binding(GO:0051010)
0.0 0.8 GO:0017080 sodium channel regulator activity(GO:0017080)