Motif ID: E2f4

Z-value: 1.944


Transcription factors associated with E2f4:

Gene SymbolEntrez IDGene Name
E2f4 ENSMUSG00000014859.8 E2f4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f4mm10_v2_chr8_+_105297663_1052977420.705.6e-06Click!


Activity profile for motif E2f4.

activity profile for motif E2f4


Sorted Z-values histogram for motif E2f4

Sorted Z-values for motif E2f4



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f4

PNG image of the network

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Top targets:


Showing 1 to 20 of 173 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_132345686 10.950 ENSMUST00000030726.6
 Rcc1
regulator of chromosome condensation 1
chr4_-_132345715 10.511 ENSMUST00000084250.4
 Rcc1
regulator of chromosome condensation 1
chr4_+_134510999 9.121 ENSMUST00000105866.2
 Aunip
aurora kinase A and ninein interacting protein
chr2_-_172940299 7.886 ENSMUST00000009143.7
 Bmp7
bone morphogenetic protein 7
chr19_+_6084983 7.833 ENSMUST00000025704.2
 Cdca5
cell division cycle associated 5
chr12_+_117843873 7.605 ENSMUST00000176735.1
ENSMUST00000177339.1
 Cdca7l

cell division cycle associated 7 like

chr6_+_124830217 6.567 ENSMUST00000131847.1
ENSMUST00000151674.1
 Cdca3

cell division cycle associated 3

chr14_-_47418407 6.241 ENSMUST00000043296.3
 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr17_-_24251382 6.236 ENSMUST00000115390.3
 Ccnf
cyclin F
chr1_-_169531343 6.111 ENSMUST00000028000.7
 Nuf2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr1_+_157412352 6.020 ENSMUST00000061537.5
 2810025M15Rik
RIKEN cDNA 2810025M15 gene
chr18_-_34751502 5.908 ENSMUST00000060710.7
 Cdc25c
cell division cycle 25C
chr7_-_38107490 5.728 ENSMUST00000108023.3
 Ccne1
cyclin E1
chr2_+_163054682 5.652 ENSMUST00000018005.3
 Mybl2
myeloblastosis oncogene-like 2
chr9_+_92250039 5.639 ENSMUST00000093801.3
 Plscr1
phospholipid scramblase 1
chr1_-_169531447 5.625 ENSMUST00000111368.1
 Nuf2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr9_+_44134562 5.438 ENSMUST00000034650.8
ENSMUST00000098852.2
 Mcam

melanoma cell adhesion molecule

chr4_-_116123618 5.335 ENSMUST00000102704.3
ENSMUST00000102705.3
 Rad54l

RAD54 like (S. cerevisiae)

chr16_-_90727329 5.198 ENSMUST00000099554.4
 Mis18a
MIS18 kinetochore protein homolog A (S. pombe)
chr6_-_56704673 5.140 ENSMUST00000170382.2
 Lsm5
LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 97 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 27.1 GO:0007052 mitotic spindle organization(GO:0007052)
0.6 14.3 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.4 12.3 GO:0006270 DNA replication initiation(GO:0006270)
0.4 11.7 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.2 9.1 GO:0007051 spindle organization(GO:0007051)
0.3 8.5 GO:0006910 phagocytosis, recognition(GO:0006910)
2.6 7.9 GO:0072076 hyaluranon cable assembly(GO:0036118) nephrogenic mesenchyme development(GO:0072076) negative regulation of glomerular mesangial cell proliferation(GO:0072125) negative regulation of glomerulus development(GO:0090194) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
2.6 7.8 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.3 7.8 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
1.9 7.6 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.3 7.6 GO:0008340 determination of adult lifespan(GO:0008340)
1.1 7.5 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.5 6.8 GO:0070986 left/right axis specification(GO:0070986)
0.9 6.2 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.1 6.0 GO:0051028 mRNA transport(GO:0051028)
2.0 5.9 GO:0000087 mitotic M phase(GO:0000087)
1.9 5.6 GO:0010911 regulation of isomerase activity(GO:0010911) positive regulation of isomerase activity(GO:0010912) phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.8 5.5 GO:0060623 regulation of chromosome condensation(GO:0060623)
0.1 5.4 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
1.0 5.2 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 20.0 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 12.4 GO:0031012 extracellular matrix(GO:0031012)
2.0 11.7 GO:0031262 Ndc80 complex(GO:0031262)
0.1 10.8 GO:0000775 chromosome, centromeric region(GO:0000775)
1.0 10.5 GO:0031080 nuclear pore outer ring(GO:0031080)
0.2 9.5 GO:0005882 intermediate filament(GO:0005882)
0.1 9.1 GO:0000922 spindle pole(GO:0000922)
1.5 8.8 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.9 7.8 GO:0008278 cohesin complex(GO:0008278)
0.1 7.8 GO:0005643 nuclear pore(GO:0005643)
0.0 6.5 GO:0030139 endocytic vesicle(GO:0030139)
0.4 6.2 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 6.2 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
1.1 5.7 GO:0031523 Myb complex(GO:0031523)
0.1 5.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 5.0 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.3 4.9 GO:0042555 MCM complex(GO:0042555)
0.6 4.5 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.6 4.4 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.2 4.3 GO:0051233 spindle midzone(GO:0051233)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 80 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.1 21.5 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.2 8.1 GO:0045309 protein phosphorylated amino acid binding(GO:0045309)
0.8 7.9 GO:0070700 BMP receptor binding(GO:0070700)
0.3 7.8 GO:0008139 nuclear localization sequence binding(GO:0008139)
1.3 7.6 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.0 7.3 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.2 5.9 GO:0050699 WW domain binding(GO:0050699)
0.8 5.7 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 5.7 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.7 5.6 GO:0042609 CD4 receptor binding(GO:0042609)
0.0 5.4 GO:0003682 chromatin binding(GO:0003682)
0.4 5.3 GO:0036310 annealing helicase activity(GO:0036310)
1.5 4.5 GO:0071207 histone pre-mRNA stem-loop binding(GO:0071207)
0.4 4.4 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.4 4.4 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.3 4.2 GO:0070182 DNA polymerase binding(GO:0070182)
1.4 4.1 GO:0032137 guanine/thymine mispair binding(GO:0032137) single guanine insertion binding(GO:0032142)
0.0 4.1 GO:0046982 protein heterodimerization activity(GO:0046982)
0.1 3.9 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 3.9 GO:0061630 ubiquitin protein ligase activity(GO:0061630)