Motif ID: E2f6

Z-value: 1.406


Transcription factors associated with E2f6:

Gene SymbolEntrez IDGene Name
E2f6 ENSMUSG00000057469.7 E2f6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f6mm10_v2_chr12_+_16810940_168109780.681.2e-05Click!


Activity profile for motif E2f6.

activity profile for motif E2f6


Sorted Z-values histogram for motif E2f6

Sorted Z-values for motif E2f6



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f6

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_45742873 5.634 ENSMUST00000026241.5
ENSMUST00000026240.7
ENSMUST00000111928.1
 Fgf8


fibroblast growth factor 8


chrX_-_141725181 5.059 ENSMUST00000067841.7
 Irs4
insulin receptor substrate 4
chr1_+_74771886 5.037 ENSMUST00000006716.6
 Wnt6
wingless-related MMTV integration site 6
chr13_-_29984219 4.676 ENSMUST00000146092.1
 E2f3
E2F transcription factor 3
chr11_+_70540260 4.481 ENSMUST00000018429.5
ENSMUST00000108557.3
ENSMUST00000108556.1
 Pld2


phospholipase D2


chr15_-_98004695 4.479 ENSMUST00000023123.8
 Col2a1
collagen, type II, alpha 1
chr12_-_56536895 4.224 ENSMUST00000001536.8
 Nkx2-1
NK2 homeobox 1
chr2_-_147186389 4.200 ENSMUST00000109970.3
ENSMUST00000067075.5
 Nkx2-2

NK2 homeobox 2

chr13_-_71963713 4.189 ENSMUST00000077337.8
 Irx1
Iroquois related homeobox 1 (Drosophila)
chr7_+_102441685 4.116 ENSMUST00000033283.9
 Rrm1
ribonucleotide reductase M1
chr4_-_11386757 4.088 ENSMUST00000108313.1
ENSMUST00000108311.2
 Esrp1

epithelial splicing regulatory protein 1

chr7_-_38107490 4.025 ENSMUST00000108023.3
 Ccne1
cyclin E1
chr11_-_102946688 3.977 ENSMUST00000057849.5
 C1ql1
complement component 1, q subcomponent-like 1
chr2_-_172940299 3.951 ENSMUST00000009143.7
 Bmp7
bone morphogenetic protein 7
chrX_+_142681398 3.908 ENSMUST00000112889.1
ENSMUST00000101198.2
ENSMUST00000112891.1
ENSMUST00000087333.2
 Tmem164



transmembrane protein 164



chr1_-_64737735 3.845 ENSMUST00000063982.5
ENSMUST00000116133.2
 Fzd5

frizzled homolog 5 (Drosophila)

chr11_+_82388900 3.824 ENSMUST00000054245.4
ENSMUST00000092852.2
 Tmem132e

transmembrane protein 132E

chr15_-_98004634 3.788 ENSMUST00000131560.1
ENSMUST00000088355.5
 Col2a1

collagen, type II, alpha 1

chr13_-_63565520 3.633 ENSMUST00000021921.5
 Ptch1
patched homolog 1
chr10_+_94036001 3.607 ENSMUST00000020208.4
 Fgd6
FYVE, RhoGEF and PH domain containing 6

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 448 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 12.0 GO:0006270 DNA replication initiation(GO:0006270)
0.7 10.9 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
1.0 10.1 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.3 7.8 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
2.3 7.0 GO:0072180 mesenchymal cell proliferation involved in ureteric bud development(GO:0072138) mesonephric duct development(GO:0072177) mesonephric duct morphogenesis(GO:0072180)
2.3 6.9 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.9 6.9 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.3 6.9 GO:0060441 epithelial tube branching involved in lung morphogenesis(GO:0060441)
0.1 6.8 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
2.1 6.2 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
1.5 6.0 GO:0015888 thiamine transport(GO:0015888)
2.8 5.6 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.4 5.6 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
1.4 5.5 GO:2000525 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.2 5.3 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.0 5.3 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
1.0 5.0 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.6 5.0 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.4 4.8 GO:0061029 eyelid development in camera-type eye(GO:0061029)
0.9 4.7 GO:0001705 ectoderm formation(GO:0001705)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 182 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 17.8 GO:0005925 focal adhesion(GO:0005925)
0.1 15.2 GO:0031012 extracellular matrix(GO:0031012)
0.0 14.4 GO:0005730 nucleolus(GO:0005730)
0.0 11.3 GO:0005667 transcription factor complex(GO:0005667)
0.8 10.1 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
1.8 9.2 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.1 8.0 GO:0031526 brush border membrane(GO:0031526)
0.1 7.4 GO:0005884 actin filament(GO:0005884)
0.3 6.2 GO:0001741 XY body(GO:0001741)
0.1 6.1 GO:0032432 actin filament bundle(GO:0032432)
0.2 5.9 GO:0005657 replication fork(GO:0005657)
0.4 5.8 GO:0042555 MCM complex(GO:0042555)
0.1 5.8 GO:0016605 PML body(GO:0016605)
0.1 5.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.8 4.9 GO:0044294 dendritic growth cone(GO:0044294)
0.2 4.5 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.1 4.4 GO:0005581 collagen trimer(GO:0005581)
0.2 4.1 GO:0071564 npBAF complex(GO:0071564)
0.8 4.0 GO:0044301 climbing fiber(GO:0044301)
0.1 4.0 GO:0031941 filamentous actin(GO:0031941)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 264 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 18.2 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1 14.7 GO:0005178 integrin binding(GO:0005178)
0.1 10.5 GO:0001047 core promoter binding(GO:0001047)
0.7 9.9 GO:0048407 platelet-derived growth factor binding(GO:0048407)
1.8 9.2 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.4 8.8 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.3 8.8 GO:0071837 HMG box domain binding(GO:0071837)
0.2 6.9 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.2 6.6 GO:0005109 frizzled binding(GO:0005109)
0.0 6.6 GO:0003729 mRNA binding(GO:0003729)
0.8 6.5 GO:0051718 DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.8 6.3 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
2.0 6.0 GO:0015234 thiamine transmembrane transporter activity(GO:0015234) thiamine uptake transmembrane transporter activity(GO:0015403)
2.0 6.0 GO:0097108 hedgehog family protein binding(GO:0097108)
0.0 5.9 GO:0008022 protein C-terminus binding(GO:0008022)
0.9 5.6 GO:0043426 MRF binding(GO:0043426)
0.1 5.4 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.2 5.1 GO:0031492 nucleosomal DNA binding(GO:0031492)
1.7 5.0 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
1.3 5.0 GO:0038049 glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)