Motif ID: E2f7

Z-value: 1.198


Transcription factors associated with E2f7:

Gene SymbolEntrez IDGene Name
E2f7 ENSMUSG00000020185.10 E2f7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f7mm10_v2_chr10_+_110745433_1107455720.531.7e-03Click!


Activity profile for motif E2f7.

activity profile for motif E2f7


Sorted Z-values histogram for motif E2f7

Sorted Z-values for motif E2f7



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f7

PNG image of the network

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Top targets:


Showing 1 to 20 of 116 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_3013140 9.676 ENSMUST00000143083.2
 Gm10721
predicted gene 10721
chr9_+_3037111 9.237 ENSMUST00000177969.1
 Gm10715
predicted gene 10715
chr9_+_3025417 8.509 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr9_+_3015654 7.176 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr9_+_3017408 6.977 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr7_-_116308241 5.870 ENSMUST00000183057.1
ENSMUST00000182487.1
ENSMUST00000181998.1
 Plekha7


pleckstrin homology domain containing, family A member 7


chr12_+_24708984 4.019 ENSMUST00000154588.1
 Rrm2
ribonucleotide reductase M2
chr4_+_108579445 3.859 ENSMUST00000102744.3
 Orc1
origin recognition complex, subunit 1
chr19_-_41206774 3.365 ENSMUST00000025986.7
ENSMUST00000169941.1
 Tll2

tolloid-like 2

chr12_+_24708241 3.310 ENSMUST00000020980.5
 Rrm2
ribonucleotide reductase M2
chr10_+_3973086 3.258 ENSMUST00000117291.1
ENSMUST00000120585.1
ENSMUST00000043735.7
 Mthfd1l


methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like


chr8_+_75109528 3.011 ENSMUST00000164309.1
 Mcm5
minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
chr10_-_69352886 2.923 ENSMUST00000119827.1
ENSMUST00000020099.5
 Cdk1

cyclin-dependent kinase 1

chr11_+_102248842 2.920 ENSMUST00000100392.4
 BC030867
cDNA sequence BC030867
chr13_-_100775844 2.739 ENSMUST00000075550.3
 Cenph
centromere protein H
chr6_-_67037399 2.720 ENSMUST00000043098.6
 Gadd45a
growth arrest and DNA-damage-inducible 45 alpha
chr2_+_112261926 2.573 ENSMUST00000028553.3
 Nop10
NOP10 ribonucleoprotein
chr14_-_20388822 2.489 ENSMUST00000022345.6
 Dnajc9
DnaJ (Hsp40) homolog, subfamily C, member 9
chr15_+_102296256 2.325 ENSMUST00000064924.4
 Espl1
extra spindle poles-like 1 (S. cerevisiae)
chr15_+_79030874 2.181 ENSMUST00000171999.1
ENSMUST00000006544.7
 Gcat

glycine C-acetyltransferase (2-amino-3-ketobutyrate-coenzyme A ligase)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 7.3 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
1.0 5.9 GO:0045218 zonula adherens maintenance(GO:0045218)
1.0 3.9 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.3 3.6 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.7 3.4 GO:0048631 regulation of skeletal muscle tissue growth(GO:0048631)
0.7 3.3 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.2 3.0 GO:0051382 kinetochore assembly(GO:0051382)
0.1 3.0 GO:0006270 DNA replication initiation(GO:0006270)
0.2 2.9 GO:0034501 protein localization to kinetochore(GO:0034501)
0.2 2.7 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.9 2.6 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
0.1 2.4 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.3 2.3 GO:0051307 meiotic chromosome separation(GO:0051307)
0.1 2.1 GO:0060236 regulation of mitotic spindle organization(GO:0060236) regulation of spindle organization(GO:0090224)
0.1 2.0 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.1 1.9 GO:0043486 histone exchange(GO:0043486)
0.6 1.7 GO:0006597 spermine biosynthetic process(GO:0006597)
0.6 1.7 GO:0040009 regulation of growth rate(GO:0040009) protein poly-ADP-ribosylation(GO:0070212)
0.3 1.7 GO:1902570 protein localization to nucleolus(GO:1902570)
0.2 1.7 GO:1990086 lens fiber cell apoptotic process(GO:1990086)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 7.3 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.5 5.9 GO:0005915 zonula adherens(GO:0005915)
0.7 5.4 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.4 5.4 GO:0042555 MCM complex(GO:0042555)
0.1 5.2 GO:0072686 mitotic spindle(GO:0072686)
0.0 3.0 GO:0000922 spindle pole(GO:0000922)
0.6 2.6 GO:0090661 box H/ACA telomerase RNP complex(GO:0090661)
0.1 2.0 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 1.8 GO:0071011 precatalytic spliceosome(GO:0071011)
0.6 1.7 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.3 1.4 GO:0001651 dense fibrillar component(GO:0001651) granular component(GO:0001652)
0.1 1.4 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 1.4 GO:0000776 kinetochore(GO:0000776)
0.2 1.3 GO:0005638 lamin filament(GO:0005638)
0.0 1.3 GO:0009925 basal plasma membrane(GO:0009925)
0.4 1.2 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.0 1.2 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.2 1.1 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063) Holliday junction resolvase complex(GO:0048476)
0.1 1.0 GO:0001740 Barr body(GO:0001740)
0.1 0.9 GO:0044613 nuclear pore central transport channel(GO:0044613) Flemming body(GO:0090543)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 7.3 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.6 7.0 GO:0070097 delta-catenin binding(GO:0070097)
0.6 4.6 GO:0003688 DNA replication origin binding(GO:0003688)
0.8 3.3 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.0 3.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 3.1 GO:0001047 core promoter binding(GO:0001047)
0.2 3.0 GO:0035173 histone kinase activity(GO:0035173)
0.6 2.6 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.1 2.1 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.3 1.8 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.0 1.8 GO:0031072 heat shock protein binding(GO:0031072)
0.4 1.7 GO:0019808 polyamine binding(GO:0019808)
0.3 1.7 GO:0070883 importin-alpha family protein binding(GO:0061676) pre-miRNA binding(GO:0070883)
0.3 1.7 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0 1.6 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.4 1.4 GO:0043515 kinetochore binding(GO:0043515)
0.2 1.4 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.1 1.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 1.3 GO:0043274 phospholipase binding(GO:0043274)
0.0 1.3 GO:0003684 damaged DNA binding(GO:0003684)