Motif ID: E2f8

Z-value: 1.705


Transcription factors associated with E2f8:

Gene SymbolEntrez IDGene Name
E2f8 ENSMUSG00000046179.11 E2f8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f8mm10_v2_chr7_-_48881596_488816190.897.4e-12Click!


Activity profile for motif E2f8.

activity profile for motif E2f8


Sorted Z-values histogram for motif E2f8

Sorted Z-values for motif E2f8



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f8

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 99 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_75109528 12.341 ENSMUST00000164309.1
 Mcm5
minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
chr12_+_24708984 9.982 ENSMUST00000154588.1
 Rrm2
ribonucleotide reductase M2
chr17_+_56040350 9.904 ENSMUST00000002914.8
 Chaf1a
chromatin assembly factor 1, subunit A (p150)
chr1_-_128359610 9.449 ENSMUST00000027601.4
 Mcm6
minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)
chr6_-_94700137 9.411 ENSMUST00000101126.2
ENSMUST00000032105.4
 Lrig1

leucine-rich repeats and immunoglobulin-like domains 1

chr17_+_56303321 8.834 ENSMUST00000001258.8
 Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr11_+_98907801 7.587 ENSMUST00000092706.6
 Cdc6
cell division cycle 6
chr12_+_24708241 7.573 ENSMUST00000020980.5
 Rrm2
ribonucleotide reductase M2
chr17_+_56303396 7.470 ENSMUST00000113038.1
 Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr7_-_115824699 7.380 ENSMUST00000169129.1
 Sox6
SRY-box containing gene 6
chr11_-_101785252 6.959 ENSMUST00000164750.1
ENSMUST00000107176.1
ENSMUST00000017868.6
 Etv4


ets variant gene 4 (E1A enhancer binding protein, E1AF)


chr16_-_18811615 6.633 ENSMUST00000096990.3
 Cdc45
cell division cycle 45
chr9_-_36726374 5.861 ENSMUST00000172702.2
ENSMUST00000172742.1
ENSMUST00000034625.5
 Chek1


checkpoint kinase 1


chr7_-_48881032 5.642 ENSMUST00000058745.8
 E2f8
E2F transcription factor 8
chr6_-_88898664 5.426 ENSMUST00000058011.6
 Mcm2
minichromosome maintenance deficient 2 mitotin (S. cerevisiae)
chr6_+_117916981 5.270 ENSMUST00000179478.1
 Hnrnpf
heterogeneous nuclear ribonucleoprotein F
chr5_+_111581422 5.193 ENSMUST00000064930.3
 C130026L21Rik
RIKEN cDNA C130026L21 gene
chr4_+_132768325 4.879 ENSMUST00000102561.4
 Rpa2
replication protein A2
chr2_+_163054682 4.847 ENSMUST00000018005.3
 Mybl2
myeloblastosis oncogene-like 2
chr13_+_94875600 4.835 ENSMUST00000022195.10
 Otp
orthopedia homolog (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 22.3 GO:0010216 maintenance of DNA methylation(GO:0010216)
0.9 19.9 GO:0006270 DNA replication initiation(GO:0006270)
1.5 19.3 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
1.8 17.6 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
1.1 10.6 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
3.4 10.3 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
0.3 9.9 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
3.1 9.4 GO:0032474 otolith morphogenesis(GO:0032474)
1.5 8.8 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
0.9 7.5 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.7 7.4 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.6 7.1 GO:0000059 protein import into nucleus, docking(GO:0000059)
1.2 7.0 GO:0033600 negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
2.2 6.6 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.3 4.9 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.3 4.8 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.1 4.8 GO:1902850 mitotic spindle assembly(GO:0090307) microtubule cytoskeleton organization involved in mitosis(GO:1902850)
0.0 4.5 GO:0098792 xenophagy(GO:0098792)
1.1 4.4 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
0.0 4.2 GO:0030010 establishment of cell polarity(GO:0030010)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 33.4 GO:0042555 MCM complex(GO:0042555)
0.5 31.4 GO:0005657 replication fork(GO:0005657)
3.5 17.6 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0 17.5 GO:0005667 transcription factor complex(GO:0005667)
3.3 9.9 GO:0033186 CAF-1 complex(GO:0033186)
0.1 7.9 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
1.1 7.5 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.3 7.3 GO:0035098 ESC/E(Z) complex(GO:0035098)
1.4 7.1 GO:0044611 nuclear pore inner ring(GO:0044611)
2.2 6.6 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.2 6.5 GO:0051233 spindle midzone(GO:0051233)
0.2 6.0 GO:0005721 pericentric heterochromatin(GO:0005721)
0.9 5.6 GO:0005663 DNA replication factor C complex(GO:0005663)
1.0 4.8 GO:0031523 Myb complex(GO:0031523)
0.3 4.5 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
1.4 4.2 GO:1990423 RZZ complex(GO:1990423)
0.1 3.7 GO:0000776 kinetochore(GO:0000776)
0.0 3.1 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.3 2.9 GO:1904115 axon cytoplasm(GO:1904115)
0.1 2.6 GO:0032590 dendrite membrane(GO:0032590)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.1 24.4 GO:0003688 DNA replication origin binding(GO:0003688)
3.5 17.6 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
5.4 16.3 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.3 13.8 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 13.1 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.1 10.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.2 9.9 GO:0070087 chromo shadow domain binding(GO:0070087)
0.3 9.8 GO:0017025 TBP-class protein binding(GO:0017025)
1.3 9.1 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 9.0 GO:0048306 calcium-dependent protein binding(GO:0048306)
2.5 7.5 GO:0071207 histone pre-mRNA stem-loop binding(GO:0071207)
0.3 7.1 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.2 6.3 GO:0032452 histone demethylase activity(GO:0032452)
0.1 6.3 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 6.0 GO:0004386 helicase activity(GO:0004386)
2.0 5.9 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.5 5.6 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 4.5 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 4.4 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.7 4.1 GO:0052630 CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity(GO:0043338) phospholactate guanylyltransferase activity(GO:0043814) ATP:coenzyme F420 adenylyltransferase activity(GO:0043910) UDP-N-acetylgalactosamine diphosphorylase activity(GO:0052630)