Motif ID: Egr1

Z-value: 2.694


Transcription factors associated with Egr1:

Gene SymbolEntrez IDGene Name
Egr1 ENSMUSG00000038418.7 Egr1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Egr1mm10_v2_chr18_+_34861200_348612150.019.4e-01Click!


Activity profile for motif Egr1.

activity profile for motif Egr1


Sorted Z-values histogram for motif Egr1

Sorted Z-values for motif Egr1



Network of associatons between targets according to the STRING database.



First level regulatory network of Egr1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_6065538 35.770 ENSMUST00000101585.3
ENSMUST00000066431.7
ENSMUST00000109815.2
ENSMUST00000109812.2
ENSMUST00000101586.2
ENSMUST00000093355.5
ENSMUST00000019133.4
 Camk2b






calcium/calmodulin-dependent protein kinase II, beta






chr11_+_98348404 18.541 ENSMUST00000078694.6
 Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr5_+_137553517 17.720 ENSMUST00000136088.1
ENSMUST00000139395.1
ENSMUST00000136565.1
ENSMUST00000149292.1
ENSMUST00000125489.1
 Actl6b




actin-like 6B




chr4_+_127169131 16.542 ENSMUST00000046659.7
 Dlgap3
discs, large (Drosophila) homolog-associated protein 3
chr14_-_33447142 14.901 ENSMUST00000111944.3
ENSMUST00000022504.5
ENSMUST00000111945.2
 Mapk8


mitogen-activated protein kinase 8


chr3_-_89322883 14.599 ENSMUST00000029673.5
 Efna3
ephrin A3
chr3_+_28263205 14.163 ENSMUST00000159236.2
 Tnik
TRAF2 and NCK interacting kinase
chr5_-_139129662 12.867 ENSMUST00000026973.7
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr18_-_34931931 12.473 ENSMUST00000180351.1
 Etf1
eukaryotic translation termination factor 1
chr11_-_98329641 12.149 ENSMUST00000041685.6
 Neurod2
neurogenic differentiation 2
chr3_+_54156039 12.096 ENSMUST00000029311.6
 Trpc4
transient receptor potential cation channel, subfamily C, member 4
chr4_-_22488296 11.917 ENSMUST00000178174.1
 Pou3f2
POU domain, class 3, transcription factor 2
chr5_-_139130159 11.718 ENSMUST00000129851.1
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr11_-_6065737 11.501 ENSMUST00000002817.5
ENSMUST00000109813.2
ENSMUST00000090443.3
 Camk2b


calcium/calmodulin-dependent protein kinase II, beta


chr6_-_126645784 11.438 ENSMUST00000055168.3
 Kcna1
potassium voltage-gated channel, shaker-related subfamily, member 1
chr5_-_115194283 10.968 ENSMUST00000112113.1
 Cabp1
calcium binding protein 1
chr8_-_84800024 10.883 ENSMUST00000126806.1
ENSMUST00000076715.6
 Nfix

nuclear factor I/X

chr5_-_99252839 10.281 ENSMUST00000168092.1
ENSMUST00000031276.8
 Rasgef1b

RasGEF domain family, member 1B

chr1_-_119422239 10.022 ENSMUST00000038765.5
 Inhbb
inhibin beta-B
chr3_+_28263563 9.796 ENSMUST00000160307.2
ENSMUST00000159680.2
ENSMUST00000160518.1
ENSMUST00000162485.1
ENSMUST00000159308.1
ENSMUST00000162777.1
ENSMUST00000161964.1
 Tnik






TRAF2 and NCK interacting kinase







Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 210 entries
Log-likelihood per target Total log-likelihoodTermDescription
15.8 47.3 GO:0032430 positive regulation of phospholipase A2 activity(GO:0032430) activation of meiosis involved in egg activation(GO:0060466)
5.0 24.8 GO:0007256 activation of JNKK activity(GO:0007256)
2.0 24.0 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
6.2 18.5 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.6 18.1 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.9 16.2 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
1.1 15.9 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.2 15.7 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)
1.0 15.3 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
3.7 14.9 GO:2000017 positive regulation of determination of dorsal identity(GO:2000017)
0.1 14.6 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.2 14.2 GO:2001237 negative regulation of extrinsic apoptotic signaling pathway(GO:2001237)
4.3 12.8 GO:1900039 positive regulation of cellular response to hypoxia(GO:1900039)
1.8 12.8 GO:0030382 sperm mitochondrion organization(GO:0030382)
2.1 12.5 GO:0032796 uropod organization(GO:0032796)
4.0 12.1 GO:2000297 negative regulation of synapse maturation(GO:2000297)
0.1 11.7 GO:0000209 protein polyubiquitination(GO:0000209)
1.0 11.6 GO:0001956 positive regulation of neurotransmitter secretion(GO:0001956)
3.8 11.4 GO:0050975 sensory perception of touch(GO:0050975)
0.8 10.8 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 91 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 49.4 GO:0045211 postsynaptic membrane(GO:0045211)
1.5 46.4 GO:0051233 spindle midzone(GO:0051233)
0.1 35.0 GO:0005768 endosome(GO:0005768)
0.1 33.9 GO:0043025 neuronal cell body(GO:0043025)
0.2 31.4 GO:0055037 recycling endosome(GO:0055037)
0.5 23.5 GO:0034704 calcium channel complex(GO:0034704)
1.8 23.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.6 19.7 GO:0032839 dendrite cytoplasm(GO:0032839)
0.6 17.4 GO:0033270 paranode region of axon(GO:0033270)
1.1 16.5 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 15.6 GO:0031225 anchored component of membrane(GO:0031225)
0.8 15.1 GO:0016514 SWI/SNF complex(GO:0016514)
0.4 14.3 GO:0048786 presynaptic active zone(GO:0048786)
0.2 13.9 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
1.7 13.5 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
1.1 13.1 GO:0097449 astrocyte projection(GO:0097449)
0.1 11.9 GO:0000139 Golgi membrane(GO:0000139)
1.9 11.7 GO:0005955 calcineurin complex(GO:0005955)
0.5 11.3 GO:0001891 phagocytic cup(GO:0001891)
2.5 10.0 GO:0043511 inhibin complex(GO:0043511)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 147 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 52.2 GO:0043274 phospholipase binding(GO:0043274)
0.1 28.4 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.2 27.4 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.1 25.4 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
2.2 24.6 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.8 22.2 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
6.2 18.5 GO:0031752 D3 dopamine receptor binding(GO:0031750) D5 dopamine receptor binding(GO:0031752)
1.7 17.4 GO:0019870 potassium channel inhibitor activity(GO:0019870)
1.2 16.8 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
1.9 14.9 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.3 14.6 GO:0046875 ephrin receptor binding(GO:0046875)
0.2 14.2 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.7 13.8 GO:0050253 prenylcysteine methylesterase activity(GO:0010296) 1-oxa-2-oxocycloheptane lactonase activity(GO:0018731) sulfolactone hydrolase activity(GO:0018732) butyrolactone hydrolase activity(GO:0018734) endosulfan lactone lactonase activity(GO:0034892) L-ascorbate 6-phosphate lactonase activity(GO:0035460) Ser-tRNA(Thr) hydrolase activity(GO:0043905) Ala-tRNA(Pro) hydrolase activity(GO:0043906) Cys-tRNA(Pro) hydrolase activity(GO:0043907) Ser(Gly)-tRNA(Ala) hydrolase activity(GO:0043908) all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity(GO:0047376) retinyl-palmitate esterase activity(GO:0050253) mannosyl-oligosaccharide 1,6-alpha-mannosidase activity(GO:0052767) mannosyl-oligosaccharide 1,3-alpha-mannosidase activity(GO:0052768) methyl indole-3-acetate esterase activity(GO:0080030) methyl salicylate esterase activity(GO:0080031) methyl jasmonate esterase activity(GO:0080032)
0.3 12.9 GO:0001540 beta-amyloid binding(GO:0001540)
3.1 12.5 GO:0016149 translation release factor activity, codon specific(GO:0016149)
1.3 12.5 GO:0032036 myosin heavy chain binding(GO:0032036)
1.0 12.1 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.6 12.1 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 11.4 GO:0005096 GTPase activator activity(GO:0005096)
0.1 11.3 GO:0101005 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)