Motif ID: Egr3

Z-value: 0.612


Transcription factors associated with Egr3:

Gene SymbolEntrez IDGene Name
Egr3 ENSMUSG00000033730.3 Egr3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Egr3mm10_v2_chr14_+_70077375_70077445-0.522.0e-03Click!


Activity profile for motif Egr3.

activity profile for motif Egr3


Sorted Z-values histogram for motif Egr3

Sorted Z-values for motif Egr3



Network of associatons between targets according to the STRING database.



First level regulatory network of Egr3

PNG image of the network

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Top targets:


Showing 1 to 20 of 115 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_110061319 3.498 ENSMUST00000098110.2
 AA474408
expressed sequence AA474408
chr17_+_87282880 1.653 ENSMUST00000041110.5
ENSMUST00000125875.1
 Ttc7

tetratricopeptide repeat domain 7

chr7_-_119184374 1.442 ENSMUST00000084650.4
 Gpr139
G protein-coupled receptor 139
chr17_-_87282793 1.292 ENSMUST00000146560.2
 4833418N02Rik
RIKEN cDNA 4833418N02 gene
chr6_-_49214954 1.235 ENSMUST00000031838.7
 Igf2bp3
insulin-like growth factor 2 mRNA binding protein 3
chr17_-_87282771 1.125 ENSMUST00000161759.1
 4833418N02Rik
RIKEN cDNA 4833418N02 gene
chr9_-_58204310 1.069 ENSMUST00000114144.2
 Islr2
immunoglobulin superfamily containing leucine-rich repeat 2
chr13_-_41847626 1.040 ENSMUST00000121404.1
 Adtrp
androgen dependent TFPI regulating protein
chr10_+_69533761 1.005 ENSMUST00000182884.1
 Ank3
ankyrin 3, epithelial
chr11_+_98937669 0.979 ENSMUST00000107475.2
ENSMUST00000068133.3
 Rara

retinoic acid receptor, alpha

chr9_-_55048544 0.962 ENSMUST00000034854.6
 Chrnb4
cholinergic receptor, nicotinic, beta polypeptide 4
chrX_-_162159717 0.948 ENSMUST00000087085.3
 Nhs
Nance-Horan syndrome (human)
chr5_-_138279960 0.945 ENSMUST00000014089.7
ENSMUST00000161827.1
 Gpc2

glypican 2 (cerebroglycan)

chr7_+_80860909 0.939 ENSMUST00000132163.1
ENSMUST00000147125.1
 Zscan2

zinc finger and SCAN domain containing 2

chr4_+_123183456 0.917 ENSMUST00000126995.1
 Hpcal4
hippocalcin-like 4
chr7_+_144896523 0.820 ENSMUST00000033389.5
 Fgf15
fibroblast growth factor 15
chr12_+_108635743 0.806 ENSMUST00000172409.1
 Evl
Ena-vasodilator stimulated phosphoprotein
chr10_+_40883819 0.787 ENSMUST00000105509.1
 Wasf1
WAS protein family, member 1
chr13_-_41847482 0.783 ENSMUST00000072012.3
 Adtrp
androgen dependent TFPI regulating protein
chr10_+_69534208 0.763 ENSMUST00000182439.1
ENSMUST00000092434.5
ENSMUST00000092432.5
ENSMUST00000092431.5
ENSMUST00000054167.8
ENSMUST00000047061.6
 Ank3





ankyrin 3, epithelial






Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.8 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 1.7 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.1 1.6 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
0.0 1.4 GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway(GO:0007200)
0.0 1.4 GO:0051028 mRNA transport(GO:0051028)
0.1 1.3 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0 1.1 GO:0045773 positive regulation of axon extension(GO:0045773)
0.3 1.0 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.3 1.0 GO:0060084 synaptic transmission involved in micturition(GO:0060084)
0.2 0.9 GO:0061626 pharyngeal arch artery morphogenesis(GO:0061626)
0.0 0.9 GO:0071364 response to epidermal growth factor(GO:0070849) cellular response to epidermal growth factor stimulus(GO:0071364)
0.0 0.9 GO:0002088 lens development in camera-type eye(GO:0002088)
0.3 0.8 GO:0021852 pyramidal neuron migration(GO:0021852)
0.2 0.8 GO:0070858 negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252)
0.1 0.8 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.0 0.7 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.6 GO:0001516 prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457)
0.0 0.6 GO:0072348 sulfur compound transport(GO:0072348)
0.2 0.5 GO:0010757 arachidonic acid metabolite production involved in inflammatory response(GO:0002538) negative regulation of plasminogen activation(GO:0010757) regulation of vascular wound healing(GO:0061043) regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.1 0.5 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)

Gene overrepresentation in cellular_component category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.8 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 1.6 GO:0000780 condensed nuclear chromosome, centromeric region(GO:0000780)
0.1 1.3 GO:0031209 SCAR complex(GO:0031209)
0.0 1.1 GO:0032587 ruffle membrane(GO:0032587)
0.1 1.0 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 0.9 GO:0005726 perichromatin fibrils(GO:0005726)
0.1 0.5 GO:0042583 chromaffin granule(GO:0042583)
0.0 0.4 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 0.3 GO:0031417 NatC complex(GO:0031417)
0.0 0.3 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.1 0.2 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.2 GO:1990745 EARP complex(GO:1990745)
0.0 0.2 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.2 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.2 GO:0031143 pseudopodium(GO:0031143)
0.0 0.2 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.1 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.0 0.1 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0 0.0 GO:0030905 retromer, tubulation complex(GO:0030905)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.6 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 2.2 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.2 1.6 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.1 1.4 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.0 1.3 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 1.3 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 1.0 GO:0004889 acetylcholine-activated cation-selective channel activity(GO:0004889)
0.1 0.9 GO:0030957 Tat protein binding(GO:0030957)
0.0 0.9 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.1 0.8 GO:0005522 profilin binding(GO:0005522)
0.0 0.8 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 0.6 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.0 0.6 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.0 0.6 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.6 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 0.4 GO:0000402 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)
0.0 0.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.4 GO:0031402 sodium ion binding(GO:0031402)
0.0 0.4 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)