Motif ID: Egr4

Z-value: 0.981


Transcription factors associated with Egr4:

Gene SymbolEntrez IDGene Name
Egr4 ENSMUSG00000071341.3 Egr4



Activity profile for motif Egr4.

activity profile for motif Egr4


Sorted Z-values histogram for motif Egr4

Sorted Z-values for motif Egr4



Network of associatons between targets according to the STRING database.



First level regulatory network of Egr4

PNG image of the network

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Top targets:


Showing 1 to 20 of 104 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_70851189 6.455 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr10_+_19591949 3.994 ENSMUST00000020188.6
 Ifngr1
interferon gamma receptor 1
chr9_+_65630552 3.803 ENSMUST00000055844.8
 Rbpms2
RNA binding protein with multiple splicing 2
chr8_-_11312731 3.571 ENSMUST00000033898.9
 Col4a1
collagen, type IV, alpha 1
chrX_-_143393893 3.459 ENSMUST00000166406.2
 Chrdl1
chordin-like 1
chr2_+_32535315 3.223 ENSMUST00000133512.1
ENSMUST00000048375.5
 Fam102a

family with sequence similarity 102, member A

chr8_+_11312805 3.184 ENSMUST00000033899.7
 Col4a2
collagen, type IV, alpha 2
chr4_+_99955715 3.150 ENSMUST00000102783.4
 Pgm2
phosphoglucomutase 2
chr2_-_102186322 2.976 ENSMUST00000111222.1
ENSMUST00000058790.5
 Ldlrad3

low density lipoprotein receptor class A domain containing 3

chr8_-_92355764 2.899 ENSMUST00000180102.1
ENSMUST00000179421.1
ENSMUST00000179222.1
ENSMUST00000179029.1
 4933436C20Rik



RIKEN cDNA 4933436C20 gene



chr6_+_4747306 2.674 ENSMUST00000175823.1
ENSMUST00000176204.1
ENSMUST00000166678.1
 Peg10


paternally expressed 10


chr4_+_130055010 2.620 ENSMUST00000123617.1
 Col16a1
collagen, type XVI, alpha 1
chr19_-_50678485 2.429 ENSMUST00000111756.3
 Sorcs1
VPS10 domain receptor protein SORCS 1
chr7_+_35119285 2.358 ENSMUST00000042985.9
 Cebpa
CCAAT/enhancer binding protein (C/EBP), alpha
chrX_-_20291776 2.121 ENSMUST00000072451.4
 Slc9a7
solute carrier family 9 (sodium/hydrogen exchanger), member 7
chr11_-_19018956 2.091 ENSMUST00000068264.7
ENSMUST00000144988.1
ENSMUST00000185131.1
 Meis1


Meis homeobox 1


chr9_+_108306205 2.034 ENSMUST00000007959.8
 Rhoa
ras homolog gene family, member A
chr19_-_50678642 2.023 ENSMUST00000072685.6
ENSMUST00000164039.2
 Sorcs1

VPS10 domain receptor protein SORCS 1

chr11_+_114851507 2.015 ENSMUST00000177952.1
 Gprc5c
G protein-coupled receptor, family C, group 5, member C
chr16_+_93883895 1.982 ENSMUST00000023666.4
ENSMUST00000117099.1
ENSMUST00000142316.1
 Chaf1b


chromatin assembly factor 1, subunit B (p60)



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 6.5 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.2 4.0 GO:0035855 megakaryocyte development(GO:0035855)
0.0 4.0 GO:0019221 cytokine-mediated signaling pathway(GO:0019221)
0.3 3.9 GO:0030238 male sex determination(GO:0030238)
0.0 3.9 GO:0007601 visual perception(GO:0007601)
0.5 3.6 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.5 3.6 GO:0061304 retinal blood vessel morphogenesis(GO:0061304)
0.1 3.5 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.2 3.2 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.0 3.0 GO:0070613 regulation of protein processing(GO:0070613)
0.0 3.0 GO:0006006 glucose metabolic process(GO:0006006)
0.1 2.7 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.1 2.6 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894)
0.1 2.5 GO:0006783 heme biosynthetic process(GO:0006783)
0.3 2.4 GO:0000050 urea cycle(GO:0000050) urea metabolic process(GO:0019627)
0.7 2.0 GO:0003100 angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001998) regulation of blood vessel size by renin-angiotensin(GO:0002034) renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure(GO:0003072) regulation of systemic arterial blood pressure by endothelin(GO:0003100) beta selection(GO:0043366)
0.1 2.0 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.6 1.8 GO:0045819 positive regulation of glycogen catabolic process(GO:0045819)
0.1 1.8 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.2 1.7 GO:0035092 sperm chromatin condensation(GO:0035092)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 6.8 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.0 4.9 GO:0005667 transcription factor complex(GO:0005667)
0.0 4.6 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 3.9 GO:0043235 receptor complex(GO:0043235)
0.1 2.8 GO:0055038 recycling endosome membrane(GO:0055038)
0.7 2.7 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 2.6 GO:0005581 collagen trimer(GO:0005581)
0.8 2.4 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.0 2.4 GO:0005681 spliceosomal complex(GO:0005681)
0.7 2.0 GO:0033186 CAF-1 complex(GO:0033186)
0.0 2.0 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.2 1.9 GO:0089701 U2AF(GO:0089701)
0.5 1.8 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
0.0 1.7 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.5 1.5 GO:0005577 fibrinogen complex(GO:0005577)
0.1 1.4 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 1.4 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 1.4 GO:0005605 basal lamina(GO:0005605)
0.3 1.3 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 1.3 GO:0030914 STAGA complex(GO:0030914)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 6.5 GO:0070410 co-SMAD binding(GO:0070410)
0.0 5.2 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
1.0 4.0 GO:0042015 interleukin-20 binding(GO:0042015)
1.3 3.9 GO:0005118 sevenless binding(GO:0005118)
0.5 3.6 GO:0005451 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.2 3.6 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.8 3.2 GO:0045131 pre-mRNA branch point binding(GO:0045131)
0.6 3.2 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.1 3.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 3.0 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 2.7 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0 2.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 2.4 GO:0001013 RNA polymerase I regulatory region DNA binding(GO:0001013)
0.2 2.0 GO:0051022 Rho GDP-dissociation inhibitor binding(GO:0051022)
0.2 1.9 GO:0050733 RS domain binding(GO:0050733)
0.6 1.8 GO:0000402 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)
0.1 1.8 GO:0000400 four-way junction DNA binding(GO:0000400)
0.0 1.8 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 1.7 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.5 1.5 GO:0070052 collagen V binding(GO:0070052)