Motif ID: Emx1_Emx2

Z-value: 0.631

Transcription factors associated with Emx1_Emx2:

Gene SymbolEntrez IDGene Name
Emx1 ENSMUSG00000033726.8 Emx1
Emx2 ENSMUSG00000043969.4 Emx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Emx1mm10_v2_chr6_+_85187438_851875100.672.0e-05Click!
Emx2mm10_v2_chr19_+_59458372_59458450-0.373.2e-02Click!


Activity profile for motif Emx1_Emx2.

activity profile for motif Emx1_Emx2


Sorted Z-values histogram for motif Emx1_Emx2

Sorted Z-values for motif Emx1_Emx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Emx1_Emx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 161 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_82505749 5.408 ENSMUST00000107245.2
ENSMUST00000107246.1
 Nfib

nuclear factor I/B

chr4_-_82505274 5.086 ENSMUST00000050872.8
ENSMUST00000064770.2
 Nfib

nuclear factor I/B

chr4_-_82505707 4.382 ENSMUST00000107248.1
ENSMUST00000107247.1
 Nfib

nuclear factor I/B

chr1_-_158356258 2.219 ENSMUST00000004133.8
 Brinp2
bone morphogenic protein/retinoic acid inducible neural-specific 2
chr3_+_127633134 2.216 ENSMUST00000029587.7
 Neurog2
neurogenin 2
chr9_-_20728219 1.825 ENSMUST00000034692.7
 Olfm2
olfactomedin 2
chr2_-_156392829 1.807 ENSMUST00000088578.2
 2900097C17Rik
RIKEN cDNA 2900097C17 gene
chr11_-_42000284 1.753 ENSMUST00000109292.2
ENSMUST00000109290.1
 Gabrg2

gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2

chr10_+_81257277 1.579 ENSMUST00000117488.1
ENSMUST00000105328.3
ENSMUST00000121205.1
 Matk


megakaryocyte-associated tyrosine kinase


chr16_-_97170707 1.475 ENSMUST00000056102.7
 Dscam
Down syndrome cell adhesion molecule
chr16_-_63864114 1.402 ENSMUST00000064405.6
 Epha3
Eph receptor A3
chr1_+_32172711 1.371 ENSMUST00000027226.5
 Khdrbs2
KH domain containing, RNA binding, signal transduction associated 2
chr17_-_36032682 1.321 ENSMUST00000102678.4
 H2-T23
histocompatibility 2, T region locus 23
chr10_+_90071095 1.307 ENSMUST00000183109.1
 Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr12_-_90969768 1.249 ENSMUST00000181184.1
 4930544I03Rik
RIKEN cDNA 4930544I03 gene
chr15_+_99006056 1.079 ENSMUST00000079818.3
 Gm8973
predicted gene 8973
chr2_-_157566319 1.021 ENSMUST00000109528.2
ENSMUST00000088494.2
 Blcap

bladder cancer associated protein homolog (human)

chr7_+_126781483 1.020 ENSMUST00000172352.1
ENSMUST00000094037.4
 Tbx6

T-box 6

chr8_-_125898291 1.002 ENSMUST00000047239.6
 Pcnxl2
pecanex-like 2 (Drosophila)
chr5_-_118244861 0.955 ENSMUST00000117177.1
ENSMUST00000133372.1
ENSMUST00000154786.1
ENSMUST00000121369.1
 Rnft2



ring finger protein, transmembrane 2




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.7 14.9 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.0 2.2 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 2.2 GO:0048469 cell maturation(GO:0048469)
0.2 1.8 GO:0071420 cellular response to histamine(GO:0071420)
0.2 1.8 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0 1.6 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.5 1.5 GO:0060060 post-embryonic retina morphogenesis in camera-type eye(GO:0060060)
0.5 1.4 GO:0097155 fasciculation of sensory neuron axon(GO:0097155)
0.4 1.3 GO:2000564 CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.1 1.3 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.3 1.1 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.3 1.0 GO:0014043 negative regulation of neuron maturation(GO:0014043)
0.0 1.0 GO:0030262 cellular component disassembly involved in execution phase of apoptosis(GO:0006921) apoptotic nuclear changes(GO:0030262)
0.4 0.8 GO:0021730 trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740)
0.3 0.8 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.1 0.8 GO:0009235 cobalamin metabolic process(GO:0009235)
0.1 0.8 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.1 0.8 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.2 0.7 GO:0035617 stress granule disassembly(GO:0035617)
0.0 0.7 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 14.9 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 1.8 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1 1.8 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 1.3 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 1.1 GO:0005814 centriole(GO:0005814)
0.3 0.8 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.1 0.8 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 0.7 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.6 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.5 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 0.4 GO:0043512 inhibin A complex(GO:0043512)
0.1 0.4 GO:1990075 kinesin II complex(GO:0016939) periciliary membrane compartment(GO:1990075)
0.0 0.4 GO:0043196 varicosity(GO:0043196)
0.0 0.4 GO:0000421 autophagosome membrane(GO:0000421)
0.0 0.4 GO:0071004 U2-type prespliceosome(GO:0071004)
0.1 0.3 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.1 0.2 GO:0071438 NADPH oxidase complex(GO:0043020) invadopodium membrane(GO:0071438)
0.0 0.1 GO:0005638 lamin filament(GO:0005638)
0.0 0.1 GO:0061617 MICOS complex(GO:0061617)
0.0 0.1 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 14.7 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 2.2 GO:0070888 E-box binding(GO:0070888)
0.1 1.8 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 1.6 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.2 1.4 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.1 1.4 GO:0008143 poly(A) binding(GO:0008143)
0.2 1.3 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 1.3 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 1.1 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 1.0 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 0.8 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 0.8 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)
0.1 0.8 GO:0051400 BH domain binding(GO:0051400)
0.2 0.7 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.0 0.7 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.6 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.6 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.6 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.2 0.5 GO:0030226 apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188)
0.1 0.5 GO:0052630 CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity(GO:0043338) phospholactate guanylyltransferase activity(GO:0043814) ATP:coenzyme F420 adenylyltransferase activity(GO:0043910) UDP-N-acetylgalactosamine diphosphorylase activity(GO:0052630)