Motif ID: En1

Z-value: 0.853


Transcription factors associated with En1:

Gene SymbolEntrez IDGene Name
En1 ENSMUSG00000058665.7 En1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
En1mm10_v2_chr1_+_120602405_120602418-0.681.1e-05Click!


Activity profile for motif En1.

activity profile for motif En1


Sorted Z-values histogram for motif En1

Sorted Z-values for motif En1



Network of associatons between targets according to the STRING database.



First level regulatory network of En1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 5.760 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr19_+_60144682 4.583 ENSMUST00000065383.4
 E330013P04Rik
RIKEN cDNA E330013P04 gene
chr14_+_67234620 4.377 ENSMUST00000176029.1
 Ebf2
early B cell factor 2
chr12_+_109453455 3.975 ENSMUST00000109844.4
ENSMUST00000109842.2
ENSMUST00000109843.1
ENSMUST00000109846.4
ENSMUST00000173539.1
ENSMUST00000109841.2
 Dlk1





delta-like 1 homolog (Drosophila)





chr15_+_102028216 3.778 ENSMUST00000023803.6
 Krt18
keratin 18
chr7_-_30973367 3.664 ENSMUST00000108116.3
 Lsr
lipolysis stimulated lipoprotein receptor
chr5_+_90772435 3.522 ENSMUST00000031320.6
 Pf4
platelet factor 4
chr16_-_26989974 3.304 ENSMUST00000089832.4
 Gmnc
geminin coiled-coil domain containing
chr13_+_98354234 3.097 ENSMUST00000105098.3
 Foxd1
forkhead box D1
chr6_+_4755327 3.013 ENSMUST00000176551.1
 Peg10
paternally expressed 10
chr12_+_109452833 2.973 ENSMUST00000056110.8
 Dlk1
delta-like 1 homolog (Drosophila)
chr2_+_174450678 2.735 ENSMUST00000016399.5
 Tubb1
tubulin, beta 1 class VI
chr10_-_120899067 2.680 ENSMUST00000092143.5
 Msrb3
methionine sulfoxide reductase B3
chr17_-_84682932 2.276 ENSMUST00000066175.3
 Abcg5
ATP-binding cassette, sub-family G (WHITE), member 5
chr4_-_129227883 2.262 ENSMUST00000106051.1
 C77080
expressed sequence C77080
chr1_-_87156127 2.253 ENSMUST00000160810.1
 Ecel1
endothelin converting enzyme-like 1
chr5_+_92925400 2.190 ENSMUST00000172706.1
 Shroom3
shroom family member 3
chr17_-_70851189 2.161 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr1_+_72824482 2.108 ENSMUST00000047328.4
 Igfbp2
insulin-like growth factor binding protein 2
chr4_-_129558387 1.953 ENSMUST00000067240.4
 Lck
lymphocyte protein tyrosine kinase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 159 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.1 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
1.0 5.8 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.3 4.4 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.1 4.0 GO:0002181 cytoplasmic translation(GO:0002181)
0.2 3.8 GO:0097284 hepatocyte apoptotic process(GO:0097284)
1.2 3.7 GO:1904274 tricellular tight junction assembly(GO:1904274)
0.7 3.6 GO:0045918 negative regulation of cytolysis(GO:0045918)
0.6 3.6 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.4 3.3 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.1 3.3 GO:0006270 DNA replication initiation(GO:0006270)
1.0 3.1 GO:0072076 nephrogenic mesenchyme development(GO:0072076)
0.0 3.0 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.5 2.7 GO:0030091 protein repair(GO:0030091)
0.3 2.4 GO:0070474 positive regulation of uterine smooth muscle contraction(GO:0070474)
0.1 2.4 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.0 2.4 GO:0051225 spindle assembly(GO:0051225)
0.8 2.3 GO:0030300 regulation of intestinal cholesterol absorption(GO:0030300)
0.1 2.2 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 2.2 GO:0003016 respiratory system process(GO:0003016)
0.0 2.2 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 82 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 15.9 GO:0005615 extracellular space(GO:0005615)
0.3 3.8 GO:0045095 keratin filament(GO:0045095)
0.6 3.7 GO:0061689 tricellular tight junction(GO:0061689)
0.2 3.6 GO:0045180 basal cortex(GO:0045180)
0.3 3.4 GO:0031091 platelet alpha granule(GO:0031091)
0.2 2.4 GO:0042788 polysomal ribosome(GO:0042788)
0.0 2.4 GO:0043296 apical junction complex(GO:0043296)
0.1 2.3 GO:0008180 COP9 signalosome(GO:0008180)
0.0 2.3 GO:0005811 lipid particle(GO:0005811)
0.7 2.2 GO:1990047 spindle matrix(GO:1990047)
0.4 2.2 GO:0044611 nuclear pore inner ring(GO:0044611)
0.1 1.8 GO:0000242 pericentriolar material(GO:0000242)
0.2 1.6 GO:0097524 sperm plasma membrane(GO:0097524)
0.1 1.6 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 1.6 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 1.5 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.1 1.5 GO:0005605 basal lamina(GO:0005605)
0.1 1.4 GO:0035102 PRC1 complex(GO:0035102)
0.1 1.3 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 1.3 GO:0005604 basement membrane(GO:0005604)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 113 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.3 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 5.0 GO:0008201 heparin binding(GO:0008201)
0.2 3.7 GO:0030228 lipoprotein particle receptor activity(GO:0030228)
1.2 3.5 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.5 3.3 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 3.2 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.2 3.0 GO:0008301 DNA binding, bending(GO:0008301)
0.0 2.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 2.8 GO:0070410 co-SMAD binding(GO:0070410)
0.4 2.7 GO:0070191 methionine-R-sulfoxide reductase activity(GO:0070191)
0.0 2.5 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.2 2.3 GO:0017127 cholesterol transporter activity(GO:0017127)
0.1 2.3 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 2.3 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 2.3 GO:0097110 scaffold protein binding(GO:0097110)
0.0 2.3 GO:0101005 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.3 2.1 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.4 2.0 GO:0042610 CD8 receptor binding(GO:0042610)
0.2 1.9 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 1.9 GO:0030246 carbohydrate binding(GO:0030246)