Motif ID: En2

Z-value: 0.515


Transcription factors associated with En2:

Gene SymbolEntrez IDGene Name
En2 ENSMUSG00000039095.7 En2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
En2mm10_v2_chr5_+_28165690_281657170.183.3e-01Click!


Activity profile for motif En2.

activity profile for motif En2


Sorted Z-values histogram for motif En2

Sorted Z-values for motif En2



Network of associatons between targets according to the STRING database.



First level regulatory network of En2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 186 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_23574381 4.447 ENSMUST00000090776.4
 Hist1h2ad
histone cluster 1, H2ad
chr5_-_62766153 3.583 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr5_-_84417359 2.737 ENSMUST00000113401.1
 Epha5
Eph receptor A5
chr17_+_3397189 2.484 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr16_+_38089001 2.090 ENSMUST00000023507.6
 Gsk3b
glycogen synthase kinase 3 beta
chr7_+_29071597 1.868 ENSMUST00000180926.1
 Gm26604
predicted gene, 26604
chr12_-_85151264 1.749 ENSMUST00000019379.7
 Rps6kl1
ribosomal protein S6 kinase-like 1
chr2_+_116067213 1.746 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr6_-_126645784 1.734 ENSMUST00000055168.3
 Kcna1
potassium voltage-gated channel, shaker-related subfamily, member 1
chr16_-_42340595 1.717 ENSMUST00000102817.4
 Gap43
growth associated protein 43
chrX_+_136741821 1.432 ENSMUST00000089350.4
 BC065397
cDNA sequence BC065397
chr4_+_21848039 1.353 ENSMUST00000098238.2
ENSMUST00000108229.1
 Sfrs18

serine/arginine-rich splicing factor 18

chr19_-_4121536 1.325 ENSMUST00000025767.7
 Aip
aryl-hydrocarbon receptor-interacting protein
chr6_+_8948608 1.320 ENSMUST00000160300.1
 Nxph1
neurexophilin 1
chr15_+_18818895 1.290 ENSMUST00000166873.2
 Cdh10
cadherin 10
chr11_+_75532099 1.269 ENSMUST00000169547.2
 Slc43a2
solute carrier family 43, member 2
chr14_-_55560340 1.258 ENSMUST00000066106.3
 A730061H03Rik
RIKEN cDNA A730061H03 gene
chr3_+_96268654 1.239 ENSMUST00000098843.2
 Hist2h3b
histone cluster 2, H3b
chr3_+_88207308 1.231 ENSMUST00000180582.1
 Gm3764
predicted gene 3764
chr10_+_73821857 1.225 ENSMUST00000177128.1
ENSMUST00000064562.7
ENSMUST00000129404.2
ENSMUST00000105426.3
ENSMUST00000131321.2
ENSMUST00000126920.2
ENSMUST00000147189.2
ENSMUST00000105424.3
ENSMUST00000092420.6
ENSMUST00000105429.3
ENSMUST00000131724.2
ENSMUST00000152655.2
ENSMUST00000151116.2
ENSMUST00000155701.2
ENSMUST00000152819.2
ENSMUST00000125517.2
ENSMUST00000124046.1
ENSMUST00000149977.2
ENSMUST00000146682.1
ENSMUST00000177107.1
 Pcdh15



















protocadherin 15




















Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.2 GO:0006342 chromatin silencing(GO:0006342)
0.0 3.1 GO:0015807 L-amino acid transport(GO:0015807)
0.3 2.7 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.3 2.4 GO:0015808 L-alanine transport(GO:0015808)
0.1 2.2 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.7 2.1 GO:1904339 negative regulation of dopaminergic neuron differentiation(GO:1904339)
0.6 1.7 GO:0050975 sensory perception of touch(GO:0050975)
0.2 1.7 GO:0016198 axon choice point recognition(GO:0016198)
0.0 1.6 GO:0051290 protein heterotetramerization(GO:0051290)
0.2 1.5 GO:0019532 oxalate transport(GO:0019532)
0.1 1.4 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.4 1.3 GO:0051342 regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051342) negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
0.1 1.3 GO:1904153 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.4 1.2 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.1 1.2 GO:0050957 equilibrioception(GO:0050957)
0.1 1.2 GO:0061157 mRNA destabilization(GO:0061157)
0.0 1.2 GO:0007608 sensory perception of smell(GO:0007608)
0.1 1.1 GO:0002227 innate immune response in mucosa(GO:0002227)
0.2 1.0 GO:0032512 regulation of protein phosphatase type 2B activity(GO:0032512) positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.2 1.0 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.3 GO:0005882 intermediate filament(GO:0005882)
0.1 3.2 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 2.9 GO:0070469 respiratory chain(GO:0070469)
0.0 2.7 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.2 2.1 GO:1990909 Wnt signalosome(GO:1990909)
0.1 1.7 GO:0031527 filopodium membrane(GO:0031527)
0.1 1.7 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 1.7 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 1.7 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.2 1.6 GO:0071437 invadopodium(GO:0071437)
0.4 1.3 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 1.3 GO:0072562 blood microparticle(GO:0072562)
0.0 1.2 GO:0032420 stereocilium(GO:0032420)
0.0 1.2 GO:0000786 nucleosome(GO:0000786)
0.0 1.2 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.1 1.0 GO:0005614 interstitial matrix(GO:0005614)
0.0 1.0 GO:0031901 early endosome membrane(GO:0031901)
0.1 0.9 GO:0031045 dense core granule(GO:0031045)
0.0 0.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 0.7 GO:0000836 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.5 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 3.1 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.3 2.7 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.0 2.5 GO:0005057 receptor signaling protein activity(GO:0005057)
0.3 2.4 GO:0015180 L-alanine transmembrane transporter activity(GO:0015180) L-proline transmembrane transporter activity(GO:0015193) alanine transmembrane transporter activity(GO:0022858)
0.1 2.3 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 2.1 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.1 1.9 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.3 1.7 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.1 1.6 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 1.5 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.4 1.3 GO:0036004 GAF domain binding(GO:0036004)
0.1 1.2 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 1.2 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.0 1.2 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 1.1 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 1.0 GO:0043495 protein anchor(GO:0043495)
0.0 1.0 GO:0001968 fibronectin binding(GO:0001968)
0.0 1.0 GO:0070412 R-SMAD binding(GO:0070412)
0.3 0.8 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)