Motif ID: Erg

Z-value: 2.077


Transcription factors associated with Erg:

Gene SymbolEntrez IDGene Name
Erg ENSMUSG00000040732.12 Erg

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ergmm10_v2_chr16_-_95459245_954593840.485.0e-03Click!


Activity profile for motif Erg.

activity profile for motif Erg


Sorted Z-values histogram for motif Erg

Sorted Z-values for motif Erg



Network of associatons between targets according to the STRING database.



First level regulatory network of Erg

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_-_38713235 17.204 ENSMUST00000023487.4
 Arhgap31
Rho GTPase activating protein 31
chr5_+_75152274 11.732 ENSMUST00000000476.8
 Pdgfra
platelet derived growth factor receptor, alpha polypeptide
chr12_+_75308308 10.467 ENSMUST00000118602.1
ENSMUST00000118966.1
ENSMUST00000055390.5
 Rhoj


ras homolog gene family, member J


chr10_+_79988584 10.262 ENSMUST00000004784.4
ENSMUST00000105374.1
 Cnn2

calponin 2

chr11_-_101785252 8.038 ENSMUST00000164750.1
ENSMUST00000107176.1
ENSMUST00000017868.6
 Etv4


ets variant gene 4 (E1A enhancer binding protein, E1AF)


chr9_-_54661666 7.000 ENSMUST00000128624.1
 Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr2_-_101883010 6.899 ENSMUST00000154525.1
 Prr5l
proline rich 5 like
chr6_-_23248264 6.702 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr12_-_56536895 6.659 ENSMUST00000001536.8
 Nkx2-1
NK2 homeobox 1
chr2_+_27677234 6.582 ENSMUST00000166775.1
 Rxra
retinoid X receptor alpha
chr14_-_25769033 6.522 ENSMUST00000069180.7
 Zcchc24
zinc finger, CCHC domain containing 24
chr6_+_134035691 6.514 ENSMUST00000081028.6
ENSMUST00000111963.1
 Etv6

ets variant gene 6 (TEL oncogene)

chr10_-_58675631 6.427 ENSMUST00000003312.4
 Edar
ectodysplasin-A receptor
chr9_-_54661870 6.417 ENSMUST00000034822.5
 Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr1_+_189728264 6.015 ENSMUST00000097442.2
 Ptpn14
protein tyrosine phosphatase, non-receptor type 14
chr11_+_90030295 5.847 ENSMUST00000092788.3
 Tmem100
transmembrane protein 100
chr6_+_4003926 5.793 ENSMUST00000031670.8
 Gng11
guanine nucleotide binding protein (G protein), gamma 11
chr19_-_44407703 5.682 ENSMUST00000041331.2
 Scd1
stearoyl-Coenzyme A desaturase 1
chr7_+_75701965 5.676 ENSMUST00000094307.3
 Akap13
A kinase (PRKA) anchor protein 13
chr12_+_33957645 5.532 ENSMUST00000049089.5
 Twist1
twist basic helix-loop-helix transcription factor 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 226 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 18.1 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway(GO:2001238)
0.9 16.6 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
2.4 12.1 GO:0006447 regulation of translational initiation by iron(GO:0006447) positive regulation of translational initiation by iron(GO:0045994)
0.3 12.1 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.4 12.0 GO:0051497 negative regulation of stress fiber assembly(GO:0051497)
3.9 11.7 GO:0035790 platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790)
3.9 11.7 GO:0038203 TORC2 signaling(GO:0038203)
0.6 10.3 GO:0050765 negative regulation of phagocytosis(GO:0050765)
1.4 10.0 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
1.4 9.7 GO:0007296 vitellogenesis(GO:0007296)
2.9 8.6 GO:0035696 monocyte extravasation(GO:0035696) regulation of monocyte extravasation(GO:2000437)
1.6 8.2 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
2.0 7.9 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.7 7.8 GO:0042572 retinol metabolic process(GO:0042572)
0.4 7.8 GO:0051127 positive regulation of actin nucleation(GO:0051127)
2.4 7.3 GO:1901552 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
1.4 7.1 GO:2001204 regulation of osteoclast development(GO:2001204)
0.4 7.1 GO:0006910 phagocytosis, recognition(GO:0006910)
2.2 6.7 GO:0021759 globus pallidus development(GO:0021759)
1.1 6.7 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 113 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 22.1 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 20.7 GO:0030027 lamellipodium(GO:0030027)
0.4 17.4 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 17.3 GO:0005730 nucleolus(GO:0005730)
0.2 15.6 GO:0005902 microvillus(GO:0005902)
0.1 14.5 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 14.0 GO:0005884 actin filament(GO:0005884)
1.5 13.1 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 12.3 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.8 11.7 GO:0031932 TORC2 complex(GO:0031932)
0.4 10.4 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.5 9.8 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 8.4 GO:0005667 transcription factor complex(GO:0005667)
0.2 7.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.7 7.4 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 7.1 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.2 6.4 GO:0005921 gap junction(GO:0005921)
0.1 6.4 GO:0005881 cytoplasmic microtubule(GO:0005881)
1.6 6.3 GO:0036454 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567)
0.2 6.3 GO:0005721 pericentric heterochromatin(GO:0005721)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 145 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 20.6 GO:0051015 actin filament binding(GO:0051015)
1.2 20.3 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.1 17.9 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.4 16.6 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.7 15.2 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 14.1 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
1.2 13.4 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 13.3 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
2.0 12.1 GO:0070644 vitamin D response element binding(GO:0070644)
0.7 11.9 GO:0017166 vinculin binding(GO:0017166)
0.3 11.6 GO:0070888 E-box binding(GO:0070888)
0.2 11.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 10.6 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.6 9.9 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
3.3 9.8 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.1 9.0 GO:0070491 repressing transcription factor binding(GO:0070491)
0.3 8.7 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 8.3 GO:0017124 SH3 domain binding(GO:0017124)
0.5 8.1 GO:1990841 promoter-specific chromatin binding(GO:1990841)
2.0 7.9 GO:0032896 palmitoyl-CoA 9-desaturase activity(GO:0032896)