Motif ID: Esr1

Z-value: 1.231


Transcription factors associated with Esr1:

Gene SymbolEntrez IDGene Name
Esr1 ENSMUSG00000019768.10 Esr1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Esr1mm10_v2_chr10_+_4611971_4612021-0.392.5e-02Click!


Activity profile for motif Esr1.

activity profile for motif Esr1


Sorted Z-values histogram for motif Esr1

Sorted Z-values for motif Esr1



Network of associatons between targets according to the STRING database.



First level regulatory network of Esr1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_102365111 7.792 ENSMUST00000006749.9
 Slc4a1
solute carrier family 4 (anion exchanger), member 1
chr9_+_54764748 7.137 ENSMUST00000034830.8
 Crabp1
cellular retinoic acid binding protein I
chr18_+_74442551 6.582 ENSMUST00000121875.1
 Myo5b
myosin VB
chr10_-_77113676 6.572 ENSMUST00000072755.4
ENSMUST00000105409.1
 Col18a1

collagen, type XVIII, alpha 1

chr18_+_74442500 6.374 ENSMUST00000074157.6
 Myo5b
myosin VB
chr2_-_166155272 6.128 ENSMUST00000088086.3
 Sulf2
sulfatase 2
chr2_+_109917639 5.052 ENSMUST00000046548.7
ENSMUST00000111037.2
 Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr12_+_109747903 4.906 ENSMUST00000183084.1
ENSMUST00000182300.1
 Mirg

miRNA containing gene

chr9_-_63711969 4.872 ENSMUST00000154323.1
 Smad3
SMAD family member 3
chr8_+_84021444 4.859 ENSMUST00000055077.6
 Palm3
paralemmin 3
chr4_+_124986430 4.792 ENSMUST00000030687.7
 Rspo1
R-spondin homolog (Xenopus laevis)
chr11_-_115612491 4.617 ENSMUST00000106507.2
 Mif4gd
MIF4G domain containing
chr6_+_4504814 4.511 ENSMUST00000141483.1
 Col1a2
collagen, type I, alpha 2
chr7_+_144915100 4.433 ENSMUST00000128057.1
 Oraov1
oral cancer overexpressed 1
chr7_-_30973399 4.413 ENSMUST00000098553.4
ENSMUST00000147431.1
 Lsr

lipolysis stimulated lipoprotein receptor

chr2_+_122147680 4.341 ENSMUST00000102476.4
 B2m
beta-2 microglobulin
chr6_-_125165707 4.326 ENSMUST00000118875.1
 Gapdh
glyceraldehyde-3-phosphate dehydrogenase
chr7_-_30973367 4.305 ENSMUST00000108116.3
 Lsr
lipolysis stimulated lipoprotein receptor
chr13_+_31806627 4.111 ENSMUST00000062292.2
 Foxc1
forkhead box C1
chr7_-_30973464 4.101 ENSMUST00000001279.8
 Lsr
lipolysis stimulated lipoprotein receptor

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 277 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.2 13.0 GO:0032439 endosome localization(GO:0032439)
4.3 12.8 GO:1904274 tricellular tight junction assembly(GO:1904274)
2.9 11.6 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.6 10.1 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.4 8.4 GO:0014823 response to activity(GO:0014823)
2.4 7.1 GO:0016115 terpenoid catabolic process(GO:0016115)
0.7 6.9 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.2 6.9 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.6 6.4 GO:0008063 Toll signaling pathway(GO:0008063)
0.9 6.3 GO:1904667 negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.1 6.3 GO:0007088 regulation of mitotic nuclear division(GO:0007088)
1.5 6.1 GO:0014846 esophagus smooth muscle contraction(GO:0014846) glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
1.2 6.1 GO:0019659 lactate biosynthetic process from pyruvate(GO:0019244) lactate biosynthetic process(GO:0019249) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
0.0 5.7 GO:0051099 positive regulation of binding(GO:0051099)
0.5 5.5 GO:2000254 regulation of male germ cell proliferation(GO:2000254)
0.8 5.4 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.3 5.2 GO:0000920 cell separation after cytokinesis(GO:0000920)
1.7 5.1 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
1.7 5.0 GO:0002765 immune response-inhibiting signal transduction(GO:0002765)
1.6 4.9 GO:0044413 evasion or tolerance of host defenses by virus(GO:0019049) positive regulation of transforming growth factor beta3 production(GO:0032916) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 138 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 13.0 GO:0045179 apical cortex(GO:0045179)
2.1 12.8 GO:0061689 tricellular tight junction(GO:0061689)
0.9 12.8 GO:0035686 sperm fibrous sheath(GO:0035686)
1.8 12.7 GO:0097452 GAIT complex(GO:0097452)
0.2 11.9 GO:0005581 collagen trimer(GO:0005581)
0.9 11.3 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 10.1 GO:0005615 extracellular space(GO:0005615)
0.1 9.9 GO:0005643 nuclear pore(GO:0005643)
0.1 8.3 GO:0014704 intercalated disc(GO:0014704)
0.0 5.8 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 5.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
1.0 4.9 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.1 4.7 GO:0005871 kinesin complex(GO:0005871)
1.5 4.5 GO:0005584 collagen type I trimer(GO:0005584)
0.0 4.3 GO:0005667 transcription factor complex(GO:0005667)
0.1 4.1 GO:0005720 nuclear heterochromatin(GO:0005720)
0.7 4.0 GO:0030896 checkpoint clamp complex(GO:0030896)
1.3 3.9 GO:0005588 collagen type V trimer(GO:0005588)
0.1 3.7 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.7 3.6 GO:0033093 Weibel-Palade body(GO:0033093)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 218 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 15.6 GO:0005198 structural molecule activity(GO:0005198)
0.7 12.3 GO:0030228 lipoprotein particle receptor activity(GO:0030228)
3.9 11.6 GO:0035605 peptidyl-cysteine S-nitrosylase activity(GO:0035605)
0.6 8.4 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 8.2 GO:0003729 mRNA binding(GO:0003729)
0.5 7.8 GO:0015106 bicarbonate transmembrane transporter activity(GO:0015106)
1.2 7.1 GO:0019841 retinol binding(GO:0019841)
1.2 6.9 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.5 6.9 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.3 6.6 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 6.6 GO:0042803 protein homodimerization activity(GO:0042803)
0.2 6.4 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
1.5 6.1 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
1.2 6.1 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.6 5.6 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
1.7 5.1 GO:0004566 beta-glucuronidase activity(GO:0004566)
1.0 4.9 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
1.6 4.8 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
1.6 4.7 GO:0009881 photoreceptor activity(GO:0009881)
0.1 4.7 GO:0003777 microtubule motor activity(GO:0003777)