Motif ID: Esr2

Z-value: 1.743


Transcription factors associated with Esr2:

Gene SymbolEntrez IDGene Name
Esr2 ENSMUSG00000021055.7 Esr2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Esr2mm10_v2_chr12_-_76177251_76177265-0.183.3e-01Click!


Activity profile for motif Esr2.

activity profile for motif Esr2


Sorted Z-values histogram for motif Esr2

Sorted Z-values for motif Esr2



Network of associatons between targets according to the STRING database.



First level regulatory network of Esr2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_32276400 20.371 ENSMUST00000020531.2
Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
chr11_+_32276893 12.975 ENSMUST00000145569.1
Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
chr7_-_103853199 11.847 ENSMUST00000033229.3
Hbb-y
hemoglobin Y, beta-like embryonic chain
chr13_+_98354234 7.473 ENSMUST00000105098.3
Foxd1
forkhead box D1
chr12_+_109459843 7.473 ENSMUST00000173812.1
Dlk1
delta-like 1 homolog (Drosophila)
chr11_-_75422524 6.770 ENSMUST00000125982.1
ENSMUST00000137103.1
Serpinf1

serine (or cysteine) peptidase inhibitor, clade F, member 1

chrX_-_106485367 6.769 ENSMUST00000140707.1
Fndc3c1
fibronectin type III domain containing 3C1
chrX_+_150547375 6.048 ENSMUST00000066337.6
ENSMUST00000112715.1
Alas2

aminolevulinic acid synthase 2, erythroid

chr11_-_75422586 5.976 ENSMUST00000138661.1
ENSMUST00000000769.7
Serpinf1

serine (or cysteine) peptidase inhibitor, clade F, member 1

chr12_+_109453455 5.940 ENSMUST00000109844.4
ENSMUST00000109842.2
ENSMUST00000109843.1
ENSMUST00000109846.4
ENSMUST00000173539.1
ENSMUST00000109841.2
Dlk1





delta-like 1 homolog (Drosophila)





chr5_-_116422858 5.724 ENSMUST00000036991.4
Hspb8
heat shock protein 8
chr11_+_78499087 5.316 ENSMUST00000017488.4
Vtn
vitronectin
chr17_-_34000257 5.021 ENSMUST00000087189.6
ENSMUST00000173075.1
ENSMUST00000172760.1
ENSMUST00000172912.1
ENSMUST00000025181.10
H2-K1




histocompatibility 2, K1, K region




chr6_+_4504814 4.957 ENSMUST00000141483.1
Col1a2
collagen, type I, alpha 2
chr9_-_119578981 4.629 ENSMUST00000117911.1
ENSMUST00000120420.1
Scn5a

sodium channel, voltage-gated, type V, alpha

chr6_-_6217023 4.504 ENSMUST00000015256.8
Slc25a13
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13
chr4_-_137785371 4.480 ENSMUST00000133473.1
Alpl
alkaline phosphatase, liver/bone/kidney
chr4_+_155839724 4.471 ENSMUST00000030947.3
Mxra8
matrix-remodelling associated 8
chr6_+_4505493 4.291 ENSMUST00000031668.8
Col1a2
collagen, type I, alpha 2
chr19_+_53529100 4.226 ENSMUST00000038287.6
Dusp5
dual specificity phosphatase 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 896 entries
Log-likelihood per target Total log-likelihoodTermDescription
9.0 45.2 GO:0015671 oxygen transport(GO:0015671)
0.6 20.7 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.6 13.0 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.4 12.9 GO:0006783 heme biosynthetic process(GO:0006783)
0.4 12.7 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
1.3 11.7 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.9 11.5 GO:0043589 skin morphogenesis(GO:0043589)
0.1 10.0 GO:0051028 mRNA transport(GO:0051028)
0.3 9.7 GO:0048821 erythrocyte development(GO:0048821)
3.2 9.5 GO:0072076 nephrogenic mesenchyme development(GO:0072076)
0.3 9.1 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.6 8.3 GO:0032463 negative regulation of protein homooligomerization(GO:0032463)
0.8 8.0 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.9 7.9 GO:0097421 liver regeneration(GO:0097421)
1.5 7.3 GO:0042637 catagen(GO:0042637)
2.4 7.2 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.2 6.5 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.9 6.3 GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
0.6 6.3 GO:2000653 regulation of genetic imprinting(GO:2000653)
1.5 6.2 GO:0032439 endosome localization(GO:0032439)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 303 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 141.9 GO:0070062 extracellular exosome(GO:0070062)
6.6 52.6 GO:0005833 hemoglobin complex(GO:0005833)
0.1 27.3 GO:0031012 extracellular matrix(GO:0031012)
0.3 18.2 GO:0005581 collagen trimer(GO:0005581)
1.4 17.9 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 17.6 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 17.0 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 11.9 GO:0005667 transcription factor complex(GO:0005667)
0.2 11.6 GO:0016459 myosin complex(GO:0016459)
3.6 10.9 GO:0005584 collagen type I trimer(GO:0005584)
0.9 10.5 GO:0043203 axon hillock(GO:0043203)
0.5 10.5 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.6 10.4 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.2 9.8 GO:0005643 nuclear pore(GO:0005643)
0.0 9.7 GO:0005739 mitochondrion(GO:0005739)
0.0 9.5 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.2 8.2 GO:0005876 spindle microtubule(GO:0005876)
0.2 8.1 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 7.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 7.7 GO:0005811 lipid particle(GO:0005811)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 574 entries
Log-likelihood per target Total log-likelihoodTermDescription
9.0 45.2 GO:0005344 oxygen transporter activity(GO:0005344)
0.6 25.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
1.1 16.8 GO:0048407 platelet-derived growth factor binding(GO:0048407)
1.1 15.9 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.8 15.5 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 12.3 GO:0008201 heparin binding(GO:0008201)
0.1 9.5 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
2.3 9.4 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.2 9.3 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.7 8.9 GO:0008301 DNA binding, bending(GO:0008301)
0.1 8.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
1.4 8.6 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.4 8.2 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.7 7.7 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.5 7.7 GO:0016594 glycine binding(GO:0016594)
0.1 7.5 GO:1990782 protein tyrosine kinase binding(GO:1990782)
1.8 7.4 GO:0031720 haptoglobin binding(GO:0031720)
0.1 7.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.3 6.9 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.2 6.5 GO:0052771 coenzyme F390-A hydrolase activity(GO:0052770) coenzyme F390-G hydrolase activity(GO:0052771)