Motif ID: Esrrb_Esrra

Z-value: 0.866

Transcription factors associated with Esrrb_Esrra:

Gene SymbolEntrez IDGene Name
Esrra ENSMUSG00000024955.7 Esrra
Esrrb ENSMUSG00000021255.11 Esrrb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Esrrbmm10_v2_chr12_+_86421628_864216620.354.5e-02Click!
Esrramm10_v2_chr19_-_6921753_6921803-0.251.6e-01Click!


Activity profile for motif Esrrb_Esrra.

activity profile for motif Esrrb_Esrra


Sorted Z-values histogram for motif Esrrb_Esrra

Sorted Z-values for motif Esrrb_Esrra



Network of associatons between targets according to the STRING database.



First level regulatory network of Esrrb_Esrra

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_+_3270767 2.779 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr8_-_13494479 2.352 ENSMUST00000033828.5
 Gas6
growth arrest specific 6
chr11_-_72266596 2.142 ENSMUST00000021161.6
ENSMUST00000140167.1
 Slc13a5

solute carrier family 13 (sodium-dependent citrate transporter), member 5

chr5_+_118027743 2.137 ENSMUST00000031304.7
 Tesc
tescalcin
chr11_+_3989924 2.005 ENSMUST00000109981.1
 Gal3st1
galactose-3-O-sulfotransferase 1
chr11_-_3504766 1.775 ENSMUST00000044507.5
 Inpp5j
inositol polyphosphate 5-phosphatase J
chr15_+_84669565 1.775 ENSMUST00000171460.1
 Prr5
proline rich 5 (renal)
chr11_-_55033398 1.761 ENSMUST00000108883.3
ENSMUST00000102727.2
 Anxa6

annexin A6

chr1_+_181352618 1.641 ENSMUST00000161880.1
ENSMUST00000027795.7
 Cnih3

cornichon homolog 3 (Drosophila)

chr11_-_4704334 1.619 ENSMUST00000058407.5
 Uqcr10
ubiquinol-cytochrome c reductase, complex III subunit X
chrX_-_72656135 1.527 ENSMUST00000055966.6
 Gabra3
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3
chr9_-_107668967 1.454 ENSMUST00000177567.1
 Slc38a3
solute carrier family 38, member 3
chr2_-_73911323 1.445 ENSMUST00000111996.1
ENSMUST00000018914.2
 Atp5g3

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9)

chr17_-_25868727 1.366 ENSMUST00000026828.5
 Fam195a
family with sequence similarity 195, member A
chr10_+_115569986 1.338 ENSMUST00000173620.1
 A930009A15Rik
RIKEN cDNA A930009A15 gene
chr9_+_44043384 1.295 ENSMUST00000114840.1
 Thy1
thymus cell antigen 1, theta
chr2_-_152951547 1.268 ENSMUST00000037715.6
 Dusp15
dual specificity phosphatase-like 15
chr12_-_86988676 1.268 ENSMUST00000095521.2
 Zdhhc22
zinc finger, DHHC-type containing 22
chr17_+_47737030 1.254 ENSMUST00000086932.3
 Tfeb
transcription factor EB
chr1_-_124045247 1.234 ENSMUST00000112603.2
 Dpp10
dipeptidylpeptidase 10

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 222 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.4 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.4 2.8 GO:0001887 selenium compound metabolic process(GO:0001887)
0.3 2.7 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.8 2.4 GO:0003104 positive regulation of glomerular filtration(GO:0003104) negative regulation of protein import into nucleus, translocation(GO:0033159) hematopoietic stem cell migration(GO:0035701) regulation of dendritic cell chemotaxis(GO:2000508) positive regulation of dendritic cell chemotaxis(GO:2000510)
0.0 2.2 GO:0032091 negative regulation of protein binding(GO:0032091)
0.5 2.1 GO:0006842 tricarboxylic acid transport(GO:0006842) succinate transport(GO:0015744) citrate transport(GO:0015746)
0.5 2.1 GO:0032417 positive regulation of sodium:proton antiporter activity(GO:0032417)
0.7 2.0 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 2.0 GO:0071277 cellular response to calcium ion(GO:0071277)
0.2 1.9 GO:0002318 myeloid progenitor cell differentiation(GO:0002318)
0.3 1.8 GO:0001980 regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980)
0.1 1.8 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.0 1.8 GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling(GO:0014068)
0.0 1.8 GO:0051865 protein autoubiquitination(GO:0051865)
0.3 1.7 GO:0046133 pyrimidine ribonucleoside catabolic process(GO:0046133)
0.0 1.7 GO:0046330 positive regulation of JNK cascade(GO:0046330)
0.1 1.6 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0 1.6 GO:0006911 phagocytosis, engulfment(GO:0006911)
0.0 1.6 GO:0007338 single fertilization(GO:0007338)
0.4 1.5 GO:0006867 asparagine transport(GO:0006867) glutamine transport(GO:0006868)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 92 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.3 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 6.5 GO:0005746 mitochondrial respiratory chain(GO:0005746)
0.2 5.3 GO:0045259 proton-transporting ATP synthase complex(GO:0045259)
0.0 3.8 GO:0001726 ruffle(GO:0001726)
0.0 3.8 GO:0031012 extracellular matrix(GO:0031012)
0.4 2.7 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.0 2.4 GO:0043209 myelin sheath(GO:0043209)
0.0 2.1 GO:0016323 basolateral plasma membrane(GO:0016323)
0.2 1.9 GO:0072546 ER membrane protein complex(GO:0072546)
0.1 1.8 GO:0031932 TORC2 complex(GO:0031932)
0.0 1.8 GO:0031902 late endosome membrane(GO:0031902)
0.0 1.6 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 1.5 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 1.5 GO:0001669 acrosomal vesicle(GO:0001669)
0.2 1.4 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.2 1.4 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 1.4 GO:0070469 respiratory chain(GO:0070469)
0.0 1.3 GO:0031514 motile cilium(GO:0031514)
0.2 1.2 GO:0005861 troponin complex(GO:0005861)
0.0 1.2 GO:0030673 axolemma(GO:0030673)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 158 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.8 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 3.6 GO:0008430 selenium binding(GO:0008430)
0.4 2.9 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.6 2.6 GO:0004111 creatine kinase activity(GO:0004111)
0.2 2.4 GO:0030296 protein tyrosine kinase activator activity(GO:0030296) receptor agonist activity(GO:0048018)
0.2 2.2 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 2.2 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.7 2.1 GO:0017153 sodium:dicarboxylate symporter activity(GO:0017153)
0.0 2.1 GO:0019212 phosphatase inhibitor activity(GO:0019212)
0.0 2.1 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.5 2.0 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733)
0.6 1.8 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.0 1.8 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 1.7 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.3 1.6 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.3 1.5 GO:0015186 L-asparagine transmembrane transporter activity(GO:0015182) L-glutamine transmembrane transporter activity(GO:0015186)
0.1 1.5 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 1.5 GO:0016247 channel regulator activity(GO:0016247)
0.1 1.4 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 1.4 GO:0045309 protein phosphorylated amino acid binding(GO:0045309)