Motif ID: Etv3_Erf_Fev_Elk4_Elk1_Elk3

Z-value: 0.910

Transcription factors associated with Etv3_Erf_Fev_Elk4_Elk1_Elk3:

Gene SymbolEntrez IDGene Name
Elk1 ENSMUSG00000009406.7 Elk1
Elk3 ENSMUSG00000008398.8 Elk3
Elk4 ENSMUSG00000026436.9 Elk4
Erf ENSMUSG00000040857.9 Erf
Etv3 ENSMUSG00000003382.12 Etv3
Fev ENSMUSG00000055197.4 Fev

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Elk1mm10_v2_chrX_-_20950597_209506130.873.1e-11Click!
Elk4mm10_v2_chr1_+_132007606_1320076340.611.6e-04Click!
Erfmm10_v2_chr7_-_25250720_25250761-0.512.5e-03Click!
Etv3mm10_v2_chr3_+_87525572_875256430.475.3e-03Click!
Elk3mm10_v2_chr10_-_93311073_933111610.183.3e-01Click!


Activity profile for motif Etv3_Erf_Fev_Elk4_Elk1_Elk3.

activity profile for motif Etv3_Erf_Fev_Elk4_Elk1_Elk3


Sorted Z-values histogram for motif Etv3_Erf_Fev_Elk4_Elk1_Elk3

Sorted Z-values for motif Etv3_Erf_Fev_Elk4_Elk1_Elk3



Network of associatons between targets according to the STRING database.



First level regulatory network of Etv3_Erf_Fev_Elk4_Elk1_Elk3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_163602331 6.210 ENSMUST00000152135.1
 Ttpal
tocopherol (alpha) transfer protein-like
chr2_-_156392829 6.175 ENSMUST00000088578.2
 2900097C17Rik
RIKEN cDNA 2900097C17 gene
chr8_-_69791170 5.031 ENSMUST00000131784.1
 Zfp866
zinc finger protein 866
chr11_-_48817332 4.919 ENSMUST00000047145.7
 Trim41
tripartite motif-containing 41
chr2_-_156312470 4.901 ENSMUST00000079125.6
 Scand1
SCAN domain-containing 1
chr5_-_3803081 4.851 ENSMUST00000043551.6
 Ankib1
ankyrin repeat and IBR domain containing 1
chr2_-_73312701 4.695 ENSMUST00000058615.9
 Cir1
corepressor interacting with RBPJ, 1
chr12_-_64965496 4.450 ENSMUST00000021331.7
 Klhl28
kelch-like 28
chr6_+_8259288 4.221 ENSMUST00000159335.1
 Gm16039
predicted gene 16039
chr7_+_44850393 4.180 ENSMUST00000136232.1
 Akt1s1
AKT1 substrate 1 (proline-rich)
chr9_-_18473559 4.156 ENSMUST00000034647.4
 Zfp558
zinc finger protein 558
chr18_-_84589491 4.125 ENSMUST00000125763.1
 Zfp407
zinc finger protein 407
chr11_+_54522872 4.122 ENSMUST00000108895.1
ENSMUST00000101206.3
 Rapgef6

Rap guanine nucleotide exchange factor (GEF) 6

chr11_+_6200029 4.064 ENSMUST00000181545.1
 A730071L15Rik
RIKEN cDNA A730071L15Rik gene
chr17_-_35979679 3.935 ENSMUST00000173724.1
ENSMUST00000172900.1
ENSMUST00000174849.1
 Prr3


proline-rich polypeptide 3


chr16_-_3872378 3.676 ENSMUST00000090522.4
 Zfp597
zinc finger protein 597
chr7_-_4546567 3.675 ENSMUST00000065957.5
 Syt5
synaptotagmin V
chr1_-_133025330 3.634 ENSMUST00000067429.3
ENSMUST00000067398.6
 Mdm4

transformed mouse 3T3 cell double minute 4

chr12_-_84970814 3.623 ENSMUST00000165886.1
ENSMUST00000167448.1
ENSMUST00000043169.7
 Arel1


apoptosis resistant E3 ubiquitin protein ligase 1


chr17_+_35135463 3.614 ENSMUST00000173535.1
ENSMUST00000173952.1
 Bag6

BCL2-associated athanogene 6


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 372 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 11.4 GO:0036506 maintenance of unfolded protein(GO:0036506) protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.1 10.9 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.5 8.4 GO:0060363 cranial suture morphogenesis(GO:0060363)
0.5 7.8 GO:0045792 negative regulation of cell size(GO:0045792)
0.2 7.8 GO:0036465 synaptic vesicle recycling(GO:0036465)
0.4 7.7 GO:0030033 microvillus assembly(GO:0030033)
0.6 6.6 GO:0051103 DNA ligation involved in DNA repair(GO:0051103)
0.1 6.4 GO:0048278 vesicle docking(GO:0048278)
0.1 6.3 GO:0003281 ventricular septum development(GO:0003281)
0.3 6.2 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
1.8 5.5 GO:0048611 ectodermal digestive tract development(GO:0007439) embryonic ectodermal digestive tract development(GO:0048611)
1.4 5.5 GO:0044565 dendritic cell proliferation(GO:0044565)
1.1 4.6 GO:0055071 cellular manganese ion homeostasis(GO:0030026) Golgi calcium ion homeostasis(GO:0032468) manganese ion homeostasis(GO:0055071)
0.0 4.6 GO:0007283 spermatogenesis(GO:0007283)
1.5 4.4 GO:1902528 regulation of protein linear polyubiquitination(GO:1902528) positive regulation of protein linear polyubiquitination(GO:1902530)
1.5 4.4 GO:0019085 early viral transcription(GO:0019085)
0.4 4.4 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.1 4.2 GO:0006829 zinc II ion transport(GO:0006829)
0.1 4.2 GO:0045761 regulation of adenylate cyclase activity(GO:0045761)
0.8 3.9 GO:0021764 amygdala development(GO:0021764)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 171 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 11.5 GO:0000407 pre-autophagosomal structure(GO:0000407)
1.6 11.4 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.2 11.0 GO:0030117 membrane coat(GO:0030117) coated membrane(GO:0048475)
0.1 10.9 GO:0005802 trans-Golgi network(GO:0005802)
0.3 10.7 GO:0030131 clathrin adaptor complex(GO:0030131)
0.1 8.5 GO:0000118 histone deacetylase complex(GO:0000118)
1.1 8.4 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 8.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.7 7.8 GO:0031931 TORC1 complex(GO:0031931)
0.1 7.5 GO:0005769 early endosome(GO:0005769)
1.4 7.1 GO:1990745 EARP complex(GO:1990745)
0.0 6.8 GO:0005815 microtubule organizing center(GO:0005815)
1.3 6.6 GO:0032807 DNA ligase IV complex(GO:0032807)
0.1 5.6 GO:0030139 endocytic vesicle(GO:0030139)
0.5 5.0 GO:0071439 clathrin complex(GO:0071439)
0.0 4.9 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.1 4.0 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 4.0 GO:0031225 anchored component of membrane(GO:0031225)
0.6 3.7 GO:0097427 microtubule bundle(GO:0097427)
0.4 3.7 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 229 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 21.6 GO:0070740 tubulin-glutamic acid ligase activity(GO:0070740)
0.0 18.5 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.6 11.8 GO:0070628 proteasome binding(GO:0070628)
0.1 11.3 GO:0017137 Rab GTPase binding(GO:0017137)
0.2 10.4 GO:0030276 clathrin binding(GO:0030276)
0.1 8.8 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.1 8.6 GO:0019905 syntaxin binding(GO:0019905)
0.5 7.6 GO:0070300 phosphatidic acid binding(GO:0070300)
0.0 6.7 GO:0017124 SH3 domain binding(GO:0017124)
0.0 6.1 GO:0008270 zinc ion binding(GO:0008270)
1.0 5.1 GO:0071253 connexin binding(GO:0071253)
0.1 5.0 GO:0070063 RNA polymerase binding(GO:0070063)
1.1 4.6 GO:0015410 manganese-transporting ATPase activity(GO:0015410)
0.1 4.6 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 4.4 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.3 4.2 GO:0016303 1-phosphatidylinositol-3-kinase activity(GO:0016303)
0.2 4.2 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 4.2 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 3.8 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 3.8 GO:0000989 transcription factor activity, transcription factor binding(GO:0000989)