Motif ID: Etv4

Z-value: 0.722


Transcription factors associated with Etv4:

Gene SymbolEntrez IDGene Name
Etv4 ENSMUSG00000017724.8 Etv4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Etv4mm10_v2_chr11_-_101785252_101785371-0.706.1e-06Click!


Activity profile for motif Etv4.

activity profile for motif Etv4


Sorted Z-values histogram for motif Etv4

Sorted Z-values for motif Etv4



Network of associatons between targets according to the STRING database.



First level regulatory network of Etv4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_56133817 3.635 ENSMUST00000167545.1
 Sema6b
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
chr15_-_66969616 2.619 ENSMUST00000170903.1
ENSMUST00000166420.1
ENSMUST00000005256.6
ENSMUST00000164070.1
 Ndrg1



N-myc downstream regulated gene 1



chr17_+_3397189 2.398 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr11_-_76509419 2.037 ENSMUST00000094012.4
 Abr
active BCR-related gene
chr6_+_115134899 1.880 ENSMUST00000009538.5
ENSMUST00000169345.1
 Syn2

synapsin II

chr17_-_80290476 1.877 ENSMUST00000086555.3
ENSMUST00000038166.7
 Dhx57

DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57

chr7_+_45627482 1.872 ENSMUST00000057927.7
 Rasip1
Ras interacting protein 1
chr13_+_109632760 1.828 ENSMUST00000135275.1
 Pde4d
phosphodiesterase 4D, cAMP specific
chr1_-_56969827 1.752 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr1_-_56969864 1.724 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr9_+_107935876 1.700 ENSMUST00000035700.8
 Camkv
CaM kinase-like vesicle-associated
chr11_-_105944412 1.687 ENSMUST00000019734.4
ENSMUST00000184269.1
ENSMUST00000150563.1
 Cyb561


cytochrome b-561


chr15_-_66812593 1.670 ENSMUST00000100572.3
 Sla
src-like adaptor
chr5_+_34543365 1.666 ENSMUST00000101316.3
 Sh3bp2
SH3-domain binding protein 2
chr6_+_55836878 1.511 ENSMUST00000044729.6
 Ccdc129
coiled-coil domain containing 129
chr6_+_5725639 1.496 ENSMUST00000115556.1
ENSMUST00000115555.1
ENSMUST00000115559.3
 Dync1i1


dynein cytoplasmic 1 intermediate chain 1


chr15_+_25984359 1.450 ENSMUST00000061875.6
 Zfp622
zinc finger protein 622
chr8_-_71723308 1.445 ENSMUST00000125092.1
 Fcho1
FCH domain only 1
chr5_+_111733924 1.401 ENSMUST00000180627.1
 Gm26897
predicted gene, 26897
chr14_-_76556662 1.394 ENSMUST00000064517.7
 Serp2
stress-associated endoplasmic reticulum protein family member 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 252 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.4 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843)
0.2 3.0 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.2 2.7 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.6 2.6 GO:0060715 syncytiotrophoblast cell differentiation involved in labyrinthine layer development(GO:0060715)
0.3 2.6 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
0.0 2.5 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 2.3 GO:0003281 ventricular septum development(GO:0003281)
0.3 2.2 GO:0036506 maintenance of unfolded protein(GO:0036506) protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.2 2.1 GO:0071225 cellular response to muramyl dipeptide(GO:0071225)
0.4 2.0 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313)
0.0 1.9 GO:0047496 vesicle transport along microtubule(GO:0047496)
0.0 1.9 GO:0010507 negative regulation of autophagy(GO:0010507)
0.3 1.6 GO:1903772 regulation of viral budding via host ESCRT complex(GO:1903772)
0.0 1.6 GO:0022900 electron transport chain(GO:0022900)
0.1 1.4 GO:0045792 negative regulation of cell size(GO:0045792)
0.1 1.4 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.1 1.3 GO:0045671 negative regulation of osteoclast differentiation(GO:0045671)
0.3 1.2 GO:0051311 spindle assembly involved in female meiosis(GO:0007056) meiotic metaphase plate congression(GO:0051311)
0.2 1.2 GO:0036438 maintenance of lens transparency(GO:0036438)
0.2 1.2 GO:0070474 positive regulation of uterine smooth muscle contraction(GO:0070474)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 116 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.3 GO:0005923 bicellular tight junction(GO:0005923)
0.0 3.7 GO:0030018 Z disc(GO:0030018)
0.0 3.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 2.9 GO:0030131 clathrin adaptor complex(GO:0030131)
0.1 2.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.3 2.7 GO:0071439 clathrin complex(GO:0071439)
0.1 2.7 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 2.6 GO:0005913 cell-cell adherens junction(GO:0005913)
0.3 2.2 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0 2.2 GO:0043204 perikaryon(GO:0043204)
0.0 1.9 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 1.5 GO:0001669 acrosomal vesicle(GO:0001669)
0.2 1.4 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 1.4 GO:0031931 TORC1 complex(GO:0031931)
0.1 1.3 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 1.3 GO:0017119 Golgi transport complex(GO:0017119)
0.0 1.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 1.2 GO:0072687 meiotic spindle(GO:0072687)
0.1 1.2 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.1 1.2 GO:0030673 axolemma(GO:0030673)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 150 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.8 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 3.6 GO:0030215 semaphorin receptor binding(GO:0030215)
0.2 3.4 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 3.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 2.9 GO:0004120 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.1 2.8 GO:0043015 gamma-tubulin binding(GO:0043015)
0.2 2.6 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 2.5 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 2.4 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 2.2 GO:0070628 proteasome binding(GO:0070628)
0.1 2.0 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1 1.9 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.6 1.7 GO:0022865 transmembrane electron transfer carrier(GO:0022865)
0.1 1.6 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 1.6 GO:0008186 ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.3 1.5 GO:0045503 dynein light chain binding(GO:0045503)
0.2 1.5 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.1 1.4 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 1.3 GO:0005088 Ras guanyl-nucleotide exchange factor activity(GO:0005088)
0.4 1.2 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)