Motif ID: Etv6

Z-value: 1.268


Transcription factors associated with Etv6:

Gene SymbolEntrez IDGene Name
Etv6 ENSMUSG00000030199.10 Etv6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Etv6mm10_v2_chr6_+_134035691_1340357170.345.0e-02Click!


Activity profile for motif Etv6.

activity profile for motif Etv6


Sorted Z-values histogram for motif Etv6

Sorted Z-values for motif Etv6



Network of associatons between targets according to the STRING database.



First level regulatory network of Etv6

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_109459843 5.476 ENSMUST00000173812.1
 Dlk1
delta-like 1 homolog (Drosophila)
chrX_-_141725181 4.390 ENSMUST00000067841.7
 Irs4
insulin receptor substrate 4
chr8_+_105297663 3.838 ENSMUST00000015003.8
 E2f4
E2F transcription factor 4
chr11_+_120948480 3.279 ENSMUST00000070653.6
 Slc16a3
solute carrier family 16 (monocarboxylic acid transporters), member 3
chr4_+_118409331 3.067 ENSMUST00000084319.4
ENSMUST00000106384.3
ENSMUST00000126089.1
ENSMUST00000073881.1
ENSMUST00000019229.8
ENSMUST00000144577.1
 Med8





mediator of RNA polymerase II transcription, subunit 8 homolog (yeast)





chr5_-_149636164 2.839 ENSMUST00000076410.4
 Hsph1
heat shock 105kDa/110kDa protein 1
chr11_-_35834492 2.760 ENSMUST00000018992.3
 Rars
arginyl-tRNA synthetase
chr7_+_127233227 2.502 ENSMUST00000056232.6
 Zfp553
zinc finger protein 553
chr9_-_21149894 2.389 ENSMUST00000019615.9
 Cdc37
cell division cycle 37
chr15_+_12824815 2.131 ENSMUST00000169061.1
 Drosha
drosha, ribonuclease type III
chr2_+_180257373 2.072 ENSMUST00000059080.6
 Rps21
ribosomal protein S21
chr2_+_84840612 2.068 ENSMUST00000111625.1
 Slc43a1
solute carrier family 43, member 1
chr3_-_95855753 2.056 ENSMUST00000161476.1
 Prpf3
PRP3 pre-mRNA processing factor 3 homolog (yeast)
chr7_+_127233044 2.051 ENSMUST00000106312.3
 Zfp553
zinc finger protein 553
chr11_-_94653964 1.985 ENSMUST00000039949.4
 Eme1
essential meiotic endonuclease 1 homolog 1 (S. pombe)
chr10_-_67285180 1.967 ENSMUST00000159002.1
ENSMUST00000077839.6
 Nrbf2

nuclear receptor binding factor 2

chr10_+_77864623 1.907 ENSMUST00000092366.2
 Tspear
thrombospondin type laminin G domain and EAR repeats
chr9_-_78489141 1.876 ENSMUST00000154207.1
 Eef1a1
eukaryotic translation elongation factor 1 alpha 1
chr15_+_12824841 1.866 ENSMUST00000090292.5
 Drosha
drosha, ribonuclease type III
chr5_-_149636331 1.863 ENSMUST00000074846.7
ENSMUST00000110498.1
ENSMUST00000127977.1
ENSMUST00000132412.1
 Hsph1



heat shock 105kDa/110kDa protein 1




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 135 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.8 GO:0006412 translation(GO:0006412)
0.1 5.8 GO:1903146 regulation of mitophagy(GO:1903146)
0.2 5.5 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.1 5.2 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.0 5.0 GO:0000398 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
1.2 4.7 GO:0045343 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343) positive regulation of MHC class I biosynthetic process(GO:0045345)
0.4 4.7 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.2 4.5 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.0 4.4 GO:0008286 insulin receptor signaling pathway(GO:0008286)
0.5 4.0 GO:0031053 production of siRNA involved in RNA interference(GO:0030422) primary miRNA processing(GO:0031053)
0.3 3.8 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.2 3.3 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.1 3.3 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.2 3.1 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.2 3.0 GO:0045116 protein neddylation(GO:0045116)
0.9 2.8 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.0 2.8 GO:0006413 translational initiation(GO:0006413)
0.4 2.6 GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447)
0.0 2.5 GO:0032543 mitochondrial translation(GO:0032543)
0.5 2.4 GO:0060334 regulation of interferon-gamma-mediated signaling pathway(GO:0060334)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 96 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.3 7.9 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.0 5.2 GO:0009897 external side of plasma membrane(GO:0009897)
0.2 5.1 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.5 4.4 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 4.2 GO:0005667 transcription factor complex(GO:0005667)
1.3 4.0 GO:1903095 microprocessor complex(GO:0070877) ribonuclease III complex(GO:1903095)
0.0 4.0 GO:0032587 ruffle membrane(GO:0032587)
0.5 3.6 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.1 3.3 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 3.2 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 3.1 GO:0016592 mediator complex(GO:0016592)
0.1 2.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 2.9 GO:0031965 nuclear membrane(GO:0031965)
0.2 2.4 GO:0034518 mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.1 2.4 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.2 2.3 GO:0000243 commitment complex(GO:0000243)
0.1 2.3 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.2 2.2 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.4 2.0 GO:0048476 Holliday junction resolvase complex(GO:0048476)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 100 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 15.1 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 14.3 GO:0044822 poly(A) RNA binding(GO:0044822)
0.3 5.4 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.1 4.7 GO:0043014 alpha-tubulin binding(GO:0043014)
0.5 4.5 GO:1990446 U1 snRNP binding(GO:1990446)
0.1 4.4 GO:0005158 insulin receptor binding(GO:0005158)
0.1 4.3 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 4.1 GO:0043851 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) rRNA methyltransferase activity(GO:0008649) rRNA (uridine-2'-O-)-methyltransferase activity(GO:0008650) rRNA (adenine-N6-)-methyltransferase activity(GO:0008988) DNA-methyltransferase activity(GO:0009008) rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383) selenocysteine methyltransferase activity(GO:0016205) rRNA (adenine) methyltransferase activity(GO:0016433) rRNA (cytosine) methyltransferase activity(GO:0016434) rRNA (guanine) methyltransferase activity(GO:0016435) rRNA (uridine) methyltransferase activity(GO:0016436) 1-phenanthrol methyltransferase activity(GO:0018707) protein-arginine N5-methyltransferase activity(GO:0019702) dimethylarsinite methyltransferase activity(GO:0034541) 4,5-dihydroxybenzo(a)pyrene methyltransferase activity(GO:0034807) 1-hydroxypyrene methyltransferase activity(GO:0034931) 1-hydroxy-6-methoxypyrene methyltransferase activity(GO:0034933) demethylmenaquinone methyltransferase activity(GO:0043770) cobalt-precorrin-6B C5-methyltransferase activity(GO:0043776) cobalt-precorrin-7 C15-methyltransferase activity(GO:0043777) cobalt-precorrin-5B C1-methyltransferase activity(GO:0043780) cobalt-precorrin-3 C17-methyltransferase activity(GO:0043782) dimethylamine methyltransferase activity(GO:0043791) hydroxyneurosporene-O-methyltransferase activity(GO:0043803) tRNA (adenine-57, 58-N(1)-) methyltransferase activity(GO:0043827) methylamine-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043833) trimethylamine methyltransferase activity(GO:0043834) methanol-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043851) monomethylamine methyltransferase activity(GO:0043852) P-methyltransferase activity(GO:0051994) Se-methyltransferase activity(GO:0051995) 2-phytyl-1,4-naphthoquinone methyltransferase activity(GO:0052624) tRNA (uracil-2'-O-)-methyltransferase activity(GO:0052665) tRNA (cytosine-2'-O-)-methyltransferase activity(GO:0052666) phosphomethylethanolamine N-methyltransferase activity(GO:0052667) tRNA (cytosine-3-)-methyltransferase activity(GO:0052735) rRNA (cytosine-2'-O-)-methyltransferase activity(GO:0070677) rRNA (cytosine-N4-)-methyltransferase activity(GO:0071424) trihydroxyferuloyl spermidine O-methyltransferase activity(GO:0080012)
0.1 3.5 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.2 3.3 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 3.1 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.4 3.0 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
0.9 2.8 GO:0004814 arginine-tRNA ligase activity(GO:0004814) arginine binding(GO:0034618)
0.1 2.5 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 2.4 GO:0019887 protein kinase regulator activity(GO:0019887)
0.1 2.3 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 2.3 GO:0017124 SH3 domain binding(GO:0017124)
0.3 2.2 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.0 2.1 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.1 1.9 GO:0003746 translation elongation factor activity(GO:0003746)