Motif ID: Evx2

Z-value: 0.667


Transcription factors associated with Evx2:

Gene SymbolEntrez IDGene Name
Evx2 ENSMUSG00000001815.9 Evx2



Activity profile for motif Evx2.

activity profile for motif Evx2


Sorted Z-values histogram for motif Evx2

Sorted Z-values for motif Evx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Evx2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_168767136 7.975 ENSMUST00000029061.5
ENSMUST00000103074.1
 Sall4

sal-like 4 (Drosophila)

chr2_-_168767029 6.005 ENSMUST00000075044.3
 Sall4
sal-like 4 (Drosophila)
chr2_-_155074447 3.000 ENSMUST00000137242.1
ENSMUST00000054607.9
 Ahcy

S-adenosylhomocysteine hydrolase

chrX_-_60893430 2.968 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr7_-_143460989 2.714 ENSMUST00000167912.1
ENSMUST00000037287.6
 Cdkn1c

cyclin-dependent kinase inhibitor 1C (P57)

chr17_+_17402672 2.624 ENSMUST00000115576.2
 Lix1
limb expression 1 homolog (chicken)
chr7_-_126800354 2.379 ENSMUST00000106348.1
 Aldoa
aldolase A, fructose-bisphosphate
chr4_-_132345686 2.037 ENSMUST00000030726.6
 Rcc1
regulator of chromosome condensation 1
chr4_-_132345715 1.994 ENSMUST00000084250.4
 Rcc1
regulator of chromosome condensation 1
chrX_+_58030999 1.960 ENSMUST00000088631.4
ENSMUST00000088629.3
 Zic3

zinc finger protein of the cerebellum 3

chr18_-_88927447 1.828 ENSMUST00000147313.1
 Socs6
suppressor of cytokine signaling 6
chr4_-_129227883 1.740 ENSMUST00000106051.1
 C77080
expressed sequence C77080
chr11_+_35121126 1.735 ENSMUST00000069837.3
 Slit3
slit homolog 3 (Drosophila)
chr13_+_51645232 1.542 ENSMUST00000075853.5
 Cks2
CDC28 protein kinase regulatory subunit 2
chr19_+_47067721 1.498 ENSMUST00000026027.5
 Taf5
TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr9_+_47530173 1.496 ENSMUST00000114548.1
ENSMUST00000152459.1
ENSMUST00000143026.1
ENSMUST00000085909.2
ENSMUST00000114547.1
ENSMUST00000034581.3
 Cadm1





cell adhesion molecule 1





chr4_-_132075250 1.478 ENSMUST00000105970.1
ENSMUST00000105975.1
 Epb4.1

erythrocyte protein band 4.1

chrX_+_58030622 1.461 ENSMUST00000088627.4
 Zic3
zinc finger protein of the cerebellum 3
chr17_-_47834682 1.427 ENSMUST00000066368.6
 Mdfi
MyoD family inhibitor
chr4_+_140701466 1.144 ENSMUST00000038893.5
ENSMUST00000138808.1
 Rcc2

regulator of chromosome condensation 2

chr3_-_130709419 1.118 ENSMUST00000043937.7
 Ostc
oligosaccharyltransferase complex subunit
chr5_-_98030727 1.117 ENSMUST00000031281.9
 Antxr2
anthrax toxin receptor 2
chr6_-_124779686 1.080 ENSMUST00000147669.1
ENSMUST00000128697.1
ENSMUST00000032218.3
ENSMUST00000112475.2
 Lrrc23



leucine rich repeat containing 23



chr14_+_62292475 0.991 ENSMUST00000166879.1
 Rnaseh2b
ribonuclease H2, subunit B
chr4_+_109978004 0.908 ENSMUST00000061187.3
 Dmrta2
doublesex and mab-3 related transcription factor like family A2
chr18_+_24603952 0.838 ENSMUST00000025120.6
 Elp2
elongator acetyltransferase complex subunit 2
chr9_-_66514567 0.817 ENSMUST00000056890.8
 Fbxl22
F-box and leucine-rich repeat protein 22
chr11_+_60537978 0.812 ENSMUST00000044250.3
 Alkbh5
alkB, alkylation repair homolog 5 (E. coli)
chr6_-_69400097 0.760 ENSMUST00000177795.1
 Igkv4-62
immunoglobulin kappa variable 4-62
chr6_+_116650674 0.737 ENSMUST00000067354.5
ENSMUST00000178241.1
 8430408G22Rik

RIKEN cDNA 8430408G22 gene

chr14_+_48446128 0.734 ENSMUST00000124720.1
 Tmem260
transmembrane protein 260
chr6_-_69284319 0.651 ENSMUST00000103349.1
 Igkv4-69
immunoglobulin kappa variable 4-69
chr7_+_51879041 0.648 ENSMUST00000107591.2
 Gas2
growth arrest specific 2
chr14_-_59365410 0.612 ENSMUST00000161031.1
ENSMUST00000160425.1
 Phf11d

PHD finger protein 11D

chr2_-_84715160 0.551 ENSMUST00000035840.5
 Zdhhc5
zinc finger, DHHC domain containing 5
chr8_-_31168699 0.527 ENSMUST00000033983.4
 Mak16
MAK16 homolog (S. cerevisiae)
chr10_-_80701811 0.523 ENSMUST00000003438.9
 Mob3a
MOB kinase activator 3A
chr14_+_73173825 0.507 ENSMUST00000166875.1
 Rcbtb2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr2_-_27475622 0.502 ENSMUST00000138693.1
ENSMUST00000113941.2
ENSMUST00000077737.6
 Brd3


bromodomain containing 3


chr10_-_128525859 0.496 ENSMUST00000026427.6
 Esyt1
extended synaptotagmin-like protein 1
chr15_-_58034289 0.476 ENSMUST00000100655.3
 9130401M01Rik
RIKEN cDNA 9130401M01 gene
chr19_-_41933276 0.473 ENSMUST00000075280.4
ENSMUST00000112123.2
 Exosc1

exosome component 1

chr17_+_36837123 0.436 ENSMUST00000179968.1
ENSMUST00000130367.1
ENSMUST00000130801.1
ENSMUST00000144182.1
ENSMUST00000123715.1
ENSMUST00000053434.8
 Trim26





tripartite motif-containing 26





chr4_-_42661893 0.420 ENSMUST00000108006.3
 Il11ra2
interleukin 11 receptor, alpha chain 2
chr3_+_121291725 0.404 ENSMUST00000039442.7
 Alg14
asparagine-linked glycosylation 14
chrM_+_7759 0.279 ENSMUST00000082407.1
ENSMUST00000082408.1
 mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chrX_-_111536325 0.264 ENSMUST00000156639.1
 Rps6ka6
ribosomal protein S6 kinase polypeptide 6
chr2_-_132247747 0.255 ENSMUST00000110163.1
ENSMUST00000180286.1
ENSMUST00000028816.2
 Tmem230


transmembrane protein 230


chr3_+_94837702 0.224 ENSMUST00000107266.1
ENSMUST00000042402.5
ENSMUST00000107269.1
 Pogz


pogo transposable element with ZNF domain


chr2_-_150255591 0.210 ENSMUST00000063463.5
 Gm21994
predicted gene 21994
chr4_+_100478806 0.192 ENSMUST00000133493.2
ENSMUST00000092730.3
ENSMUST00000106979.3
 Ube2u


ubiquitin-conjugating enzyme E2U (putative)


chr8_+_92855319 0.191 ENSMUST00000046290.1
 Lpcat2
lysophosphatidylcholine acyltransferase 2
chr12_+_109545390 0.143 ENSMUST00000146701.1
 Meg3
maternally expressed 3
chr2_+_69822370 0.139 ENSMUST00000053087.3
 Klhl23
kelch-like 23
chr8_+_14888022 0.106 ENSMUST00000123990.1
ENSMUST00000027554.7
 Cln8

ceroid-lipofuscinosis, neuronal 8

chr8_-_35495487 0.042 ENSMUST00000033927.6
 Eri1
exoribonuclease 1
chr1_-_184999549 0.028 ENSMUST00000027929.4
 Mark1
MAP/microtubule affinity-regulating kinase 1
chr3_+_94837533 0.014 ENSMUST00000107270.2
 Pogz
pogo transposable element with ZNF domain
chr2_+_91256813 0.008 ENSMUST00000144394.1
ENSMUST00000028694.5
ENSMUST00000168916.1
ENSMUST00000156919.1
 Pacsin3



protein kinase C and casein kinase substrate in neurons 3



chr13_+_38204928 0.002 ENSMUST00000091641.5
ENSMUST00000178564.1
 Snrnp48

small nuclear ribonucleoprotein 48 (U11/U12)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 14.0 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.6 3.4 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.5 1.5 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.4 1.1 GO:0072356 chromosome passenger complex localization to kinetochore(GO:0072356)
0.4 3.0 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.3 1.7 GO:0070100 negative regulation of chemokine-mediated signaling pathway(GO:0070100)
0.2 2.4 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.2 0.8 GO:0035553 oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.2 3.0 GO:0007530 sex determination(GO:0007530)
0.1 2.7 GO:0060065 uterus development(GO:0060065)
0.1 2.6 GO:0097352 autophagosome maturation(GO:0097352)
0.1 1.4 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
0.1 0.9 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.0 0.9 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.0 0.2 GO:0046469 platelet activating factor biosynthetic process(GO:0006663) platelet activating factor metabolic process(GO:0046469)
0.0 4.0 GO:0007052 mitotic spindle organization(GO:0007052)
0.0 0.1 GO:0021523 somatic motor neuron differentiation(GO:0021523) amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.0 1.8 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.4 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.0 1.5 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 1.1 GO:1901998 toxin transport(GO:1901998)
0.0 0.3 GO:2000381 negative regulation of mesoderm development(GO:2000381)
0.0 0.5 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.0 0.5 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.2 GO:0051382 kinetochore assembly(GO:0051382)
0.0 0.8 GO:1904892 regulation of JAK-STAT cascade(GO:0046425) regulation of STAT cascade(GO:1904892)
0.0 0.3 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.1 16.6 GO:0000792 heterochromatin(GO:0000792)
0.1 0.8 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.1 1.5 GO:0070852 cell body fiber(GO:0070852)
0.1 1.1 GO:1990023 mitotic spindle midzone(GO:1990023)
0.1 1.1 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 1.5 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.1 4.0 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 0.5 GO:0044232 organelle membrane contact site(GO:0044232)
0.0 1.8 GO:0001772 immunological synapse(GO:0001772)
0.0 0.5 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.5 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.5 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 4.0 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.4 3.0 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.4 2.4 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.2 1.7 GO:0048495 Roundabout binding(GO:0048495)
0.2 0.8 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.2 2.7 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 1.0 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.1 3.0 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 0.2 GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.0 1.5 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.8 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.5 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 1.5 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 0.5 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.0 17.9 GO:0044212 transcription regulatory region DNA binding(GO:0044212)
0.0 1.1 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 0.0 GO:0071207 histone pre-mRNA stem-loop binding(GO:0071207)
0.0 1.3 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 1.5 GO:0030165 PDZ domain binding(GO:0030165)