Motif ID: Ezh2_Atf2_Ikzf1

Z-value: 2.151

Transcription factors associated with Ezh2_Atf2_Ikzf1:

Gene SymbolEntrez IDGene Name
Atf2 ENSMUSG00000027104.12 Atf2
Ezh2 ENSMUSG00000029687.10 Ezh2
Ikzf1 ENSMUSG00000018654.11 Ikzf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Atf2mm10_v2_chr2_-_73892588_738926160.875.7e-11Click!
Ezh2mm10_v2_chr6_-_47594967_47595047-0.096.1e-01Click!


Activity profile for motif Ezh2_Atf2_Ikzf1.

activity profile for motif Ezh2_Atf2_Ikzf1


Sorted Z-values histogram for motif Ezh2_Atf2_Ikzf1

Sorted Z-values for motif Ezh2_Atf2_Ikzf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Ezh2_Atf2_Ikzf1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_152081529 33.267 ENSMUST00000064061.3
 Scrt2
scratch homolog 2, zinc finger protein (Drosophila)
chr4_-_82505749 24.937 ENSMUST00000107245.2
ENSMUST00000107246.1
 Nfib

nuclear factor I/B

chr4_-_82505707 21.787 ENSMUST00000107248.1
ENSMUST00000107247.1
 Nfib

nuclear factor I/B

chr16_-_23520579 18.319 ENSMUST00000089883.5
 Masp1
mannan-binding lectin serine peptidase 1
chr13_+_54371340 15.722 ENSMUST00000026985.8
 Cplx2
complexin 2
chr6_+_141524379 14.897 ENSMUST00000032362.9
 Slco1c1
solute carrier organic anion transporter family, member 1c1
chr7_-_79386943 13.626 ENSMUST00000053718.8
ENSMUST00000179243.1
 Rlbp1

retinaldehyde binding protein 1

chr5_+_98180866 12.476 ENSMUST00000112959.1
 Prdm8
PR domain containing 8
chr14_-_79771305 12.004 ENSMUST00000039568.5
 Pcdh8
protocadherin 8
chr8_-_84773381 11.577 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr1_+_66175286 11.559 ENSMUST00000114017.1
ENSMUST00000114015.1
 Map2

microtubule-associated protein 2

chr19_+_26623419 11.472 ENSMUST00000176584.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr15_-_76521902 11.454 ENSMUST00000164703.1
ENSMUST00000096365.3
 Scrt1

scratch homolog 1, zinc finger protein (Drosophila)

chr9_+_27790947 11.161 ENSMUST00000115243.2
 Opcml
opioid binding protein/cell adhesion molecule-like
chr1_-_154725920 11.125 ENSMUST00000004214.8
 Cacna1e
calcium channel, voltage-dependent, R type, alpha 1E subunit
chr12_-_78980758 11.006 ENSMUST00000174072.1
 Tmem229b
transmembrane protein 229B
chr3_-_80802789 10.785 ENSMUST00000107745.1
ENSMUST00000075316.4
 Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr9_-_117252450 10.633 ENSMUST00000111773.3
ENSMUST00000068962.7
ENSMUST00000044901.7
 Rbms3


RNA binding motif, single stranded interacting protein


chrX_-_73869804 10.328 ENSMUST00000066576.5
ENSMUST00000114430.1
 L1cam

L1 cell adhesion molecule

chr4_+_101550411 10.294 ENSMUST00000094953.4
ENSMUST00000106933.1
 Dnajc6

DnaJ (Hsp40) homolog, subfamily C, member 6


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 388 entries
Log-likelihood per target Total log-likelihoodTermDescription
12.2 48.9 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
1.2 40.3 GO:2001222 regulation of neuron migration(GO:2001222)
0.5 37.9 GO:0001578 microtubule bundle formation(GO:0001578)
0.3 35.5 GO:0007612 learning(GO:0007612)
1.0 31.3 GO:0060074 synapse maturation(GO:0060074)
0.4 30.6 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.6 24.4 GO:0006376 mRNA splice site selection(GO:0006376)
1.2 19.8 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
1.4 19.2 GO:0021540 corpus callosum morphogenesis(GO:0021540)
0.5 18.6 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
2.6 18.3 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.2 18.2 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
3.0 15.2 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
2.9 14.6 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
1.4 14.4 GO:0015721 bile acid and bile salt transport(GO:0015721)
1.3 13.9 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
1.5 13.8 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.6 13.0 GO:2000463 positive regulation of excitatory postsynaptic potential(GO:2000463)
0.1 13.0 GO:0071805 potassium ion transmembrane transport(GO:0071805)
1.6 12.5 GO:0097369 sodium ion import(GO:0097369)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 168 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 53.8 GO:0042734 presynaptic membrane(GO:0042734)
2.5 51.9 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 38.5 GO:0016021 integral component of membrane(GO:0016021)
3.7 33.0 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 26.6 GO:0045211 postsynaptic membrane(GO:0045211)
1.2 24.4 GO:0016514 SWI/SNF complex(GO:0016514)
1.4 23.0 GO:0032279 asymmetric synapse(GO:0032279)
0.5 22.5 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.2 20.3 GO:0000118 histone deacetylase complex(GO:0000118)
0.3 18.6 GO:0030315 T-tubule(GO:0030315)
1.4 18.4 GO:0042788 polysomal ribosome(GO:0042788)
3.9 15.7 GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.9 14.2 GO:0005614 interstitial matrix(GO:0005614)
0.0 14.2 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 14.1 GO:0043204 perikaryon(GO:0043204)
0.1 13.8 GO:0030027 lamellipodium(GO:0030027)
0.2 12.8 GO:0035097 histone methyltransferase complex(GO:0035097)
0.4 10.3 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.6 9.4 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 9.3 GO:0031225 anchored component of membrane(GO:0031225)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 277 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 38.0 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
4.0 32.2 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
1.0 23.4 GO:0017075 syntaxin-1 binding(GO:0017075)
3.3 23.2 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 22.3 GO:0015631 tubulin binding(GO:0015631)
1.1 18.9 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
1.5 18.3 GO:0097109 neuroligin family protein binding(GO:0097109)
0.5 17.9 GO:0017091 AU-rich element binding(GO:0017091)
0.1 17.7 GO:0017124 SH3 domain binding(GO:0017124)
0.1 17.2 GO:0003729 mRNA binding(GO:0003729)
0.2 17.1 GO:0048306 calcium-dependent protein binding(GO:0048306)
1.1 15.1 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
3.7 14.9 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.1 14.1 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738) protein-glutamic acid ligase activity(GO:0070739) tubulin-glutamic acid ligase activity(GO:0070740)
2.3 13.6 GO:0019841 retinol binding(GO:0019841)
2.1 12.7 GO:0032051 clathrin light chain binding(GO:0032051)
1.6 12.5 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.4 11.0 GO:0001968 fibronectin binding(GO:0001968)
0.1 11.0 GO:0042393 histone binding(GO:0042393)
2.0 10.2 GO:0033691 sialic acid binding(GO:0033691)