Motif ID: Fosl2_Bach2

Z-value: 0.772

Transcription factors associated with Fosl2_Bach2:

Gene SymbolEntrez IDGene Name
Bach2 ENSMUSG00000040270.10 Bach2
Fosl2 ENSMUSG00000029135.9 Fosl2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Fosl2mm10_v2_chr5_+_32136458_321365050.722.0e-06Click!
Bach2mm10_v2_chr4_+_32238950_322389640.485.2e-03Click!


Activity profile for motif Fosl2_Bach2.

activity profile for motif Fosl2_Bach2


Sorted Z-values histogram for motif Fosl2_Bach2

Sorted Z-values for motif Fosl2_Bach2



Network of associatons between targets according to the STRING database.



First level regulatory network of Fosl2_Bach2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_33907721 4.748 ENSMUST00000115161.1
ENSMUST00000062289.8
 Bend6

BEN domain containing 6

chr14_+_65968483 4.207 ENSMUST00000022616.6
 Clu
clusterin
chr7_+_126776939 3.153 ENSMUST00000038614.5
ENSMUST00000170882.1
ENSMUST00000106359.1
ENSMUST00000106357.1
ENSMUST00000145762.1
ENSMUST00000132643.1
ENSMUST00000106356.1
 Ypel3






yippee-like 3 (Drosophila)






chr6_+_124996681 3.080 ENSMUST00000032479.4
 Pianp
PILR alpha associated neural protein
chr3_+_55461758 2.703 ENSMUST00000070418.4
 Dclk1
doublecortin-like kinase 1
chr18_+_32938955 2.600 ENSMUST00000042868.4
 Camk4
calcium/calmodulin-dependent protein kinase IV
chr2_-_45110241 2.538 ENSMUST00000177302.1
 Zeb2
zinc finger E-box binding homeobox 2
chr13_+_54949388 2.484 ENSMUST00000026994.7
ENSMUST00000109994.2
 Unc5a

unc-5 homolog A (C. elegans)

chr7_+_139834148 2.446 ENSMUST00000026548.7
 Gpr123
G protein-coupled receptor 123
chr14_+_27622433 2.420 ENSMUST00000090302.5
 Erc2
ELKS/RAB6-interacting/CAST family member 2
chr9_-_20728219 2.399 ENSMUST00000034692.7
 Olfm2
olfactomedin 2
chr6_-_124769548 2.342 ENSMUST00000149652.1
ENSMUST00000112476.1
ENSMUST00000004378.8
 Eno2


enolase 2, gamma neuronal


chr9_-_96752822 2.263 ENSMUST00000152594.1
 Zbtb38
zinc finger and BTB domain containing 38
chr13_-_54611274 2.159 ENSMUST00000049575.7
 Cltb
clathrin, light polypeptide (Lcb)
chr13_-_54611332 2.091 ENSMUST00000091609.4
 Cltb
clathrin, light polypeptide (Lcb)
chr8_+_95703037 2.083 ENSMUST00000073139.7
ENSMUST00000080666.7
 Ndrg4

N-myc downstream regulated gene 4

chr3_-_84220853 2.003 ENSMUST00000154152.1
ENSMUST00000107693.2
ENSMUST00000107695.2
 Trim2


tripartite motif-containing 2


chr14_-_36968679 1.916 ENSMUST00000067700.6
 Ccser2
coiled-coil serine rich 2
chr18_+_37955544 1.885 ENSMUST00000070709.2
ENSMUST00000177058.1
ENSMUST00000169360.2
ENSMUST00000163591.2
ENSMUST00000091932.5
 Rell2




RELT-like 2




chrY_-_1286563 1.859 ENSMUST00000091190.5
 Ddx3y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 129 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.0 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
0.1 4.7 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.7 4.2 GO:1902847 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of tau-protein kinase activity(GO:1902949)
0.0 3.6 GO:0001578 microtubule bundle formation(GO:0001578)
0.6 3.5 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.9 3.4 GO:1904177 regulation of adipose tissue development(GO:1904177)
0.8 3.2 GO:2000774 positive regulation of cellular senescence(GO:2000774)
0.3 2.8 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.3 2.8 GO:0071635 negative regulation of transforming growth factor beta production(GO:0071635)
0.1 2.7 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.3 2.5 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.1 2.5 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571)
0.0 2.5 GO:0007266 Rho protein signal transduction(GO:0007266)
0.2 2.3 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.0 2.3 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
0.3 2.2 GO:0032261 purine nucleotide salvage(GO:0032261) IMP salvage(GO:0032264)
0.2 2.1 GO:2001135 regulation of endocytic recycling(GO:2001135)
0.2 2.0 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.2 1.9 GO:1902993 positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
0.0 1.9 GO:0006275 regulation of DNA replication(GO:0006275)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.0 GO:0042734 presynaptic membrane(GO:0042734)
0.0 6.9 GO:0045211 postsynaptic membrane(GO:0045211)
0.4 4.3 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.6 4.2 GO:0034366 spherical high-density lipoprotein particle(GO:0034366) neurofibrillary tangle(GO:0097418)
0.5 3.4 GO:0005638 lamin filament(GO:0005638)
0.0 3.4 GO:0005604 basement membrane(GO:0005604)
0.0 2.7 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.1 2.5 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 2.4 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 2.4 GO:0055037 recycling endosome(GO:0055037)
0.5 2.3 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 2.0 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 1.9 GO:0036464 cytoplasmic ribonucleoprotein granule(GO:0036464)
0.5 1.8 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.4 1.7 GO:0031673 H zone(GO:0031673)
0.2 1.7 GO:0001520 outer dense fiber(GO:0001520)
0.0 1.5 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.4 1.4 GO:0043259 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259)
0.0 1.4 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 1.4 GO:0043198 dendritic shaft(GO:0043198)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 102 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.7 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 4.4 GO:0005096 GTPase activator activity(GO:0005096)
0.5 4.3 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.2 4.2 GO:0051787 misfolded protein binding(GO:0051787)
0.1 3.7 GO:0070412 R-SMAD binding(GO:0070412)
0.1 3.5 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 3.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 3.3 GO:0008017 microtubule binding(GO:0008017)
0.1 3.0 GO:0042805 actinin binding(GO:0042805)
0.1 2.6 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 2.6 GO:0017022 myosin binding(GO:0017022)
0.0 2.6 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.4 2.5 GO:0005042 netrin receptor activity(GO:0005042)
0.1 2.5 GO:0043531 ADP binding(GO:0043531)
0.3 2.3 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 2.3 GO:0008327 methyl-CpG binding(GO:0008327)
0.5 2.2 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.3 2.2 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 2.2 GO:0005518 collagen binding(GO:0005518)
0.0 2.2 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)