Motif ID: Foxa2_Foxa1

Z-value: 1.780

Transcription factors associated with Foxa2_Foxa1:

Gene SymbolEntrez IDGene Name
Foxa1 ENSMUSG00000035451.6 Foxa1
Foxa2 ENSMUSG00000037025.5 Foxa2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxa2mm10_v2_chr2_-_148046896_1480469910.327.1e-02Click!
Foxa1mm10_v2_chr12_-_57546121_575461410.173.5e-01Click!


Activity profile for motif Foxa2_Foxa1.

activity profile for motif Foxa2_Foxa1


Sorted Z-values histogram for motif Foxa2_Foxa1

Sorted Z-values for motif Foxa2_Foxa1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxa2_Foxa1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_75152274 20.026 ENSMUST00000000476.8
 Pdgfra
platelet derived growth factor receptor, alpha polypeptide
chr14_-_48662740 15.777 ENSMUST00000122009.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr7_+_113765998 13.338 ENSMUST00000046687.9
 Spon1
spondin 1, (f-spondin) extracellular matrix protein
chr6_+_5390387 12.435 ENSMUST00000183358.1
 Asb4
ankyrin repeat and SOCS box-containing 4
chr12_-_56535047 12.262 ENSMUST00000178477.2
 Nkx2-1
NK2 homeobox 1
chr5_+_16553488 9.912 ENSMUST00000030683.3
 Hgf
hepatocyte growth factor
chr7_+_113766119 9.228 ENSMUST00000084696.4
 Spon1
spondin 1, (f-spondin) extracellular matrix protein
chr16_-_22439719 8.903 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr13_+_49582745 8.542 ENSMUST00000065494.7
 Omd
osteomodulin
chr1_+_51289106 8.324 ENSMUST00000051572.6
 Sdpr
serum deprivation response
chr2_-_172940299 8.224 ENSMUST00000009143.7
 Bmp7
bone morphogenetic protein 7
chr1_+_12718496 8.177 ENSMUST00000088585.3
 Sulf1
sulfatase 1
chr18_-_47333311 8.044 ENSMUST00000126684.1
ENSMUST00000156422.1
 Sema6a

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

chr5_-_51567717 7.383 ENSMUST00000127135.1
ENSMUST00000151104.1
 Ppargc1a

peroxisome proliferative activated receptor, gamma, coactivator 1 alpha

chr2_-_147186389 7.346 ENSMUST00000109970.3
ENSMUST00000067075.5
 Nkx2-2

NK2 homeobox 2

chr19_+_23141183 7.333 ENSMUST00000036884.1
 Klf9
Kruppel-like factor 9
chr17_-_70851710 7.230 ENSMUST00000166395.2
 Tgif1
TGFB-induced factor homeobox 1
chr11_-_68386821 7.225 ENSMUST00000021284.3
 Ntn1
netrin 1
chr10_+_99263224 7.088 ENSMUST00000020118.4
 Dusp6
dual specificity phosphatase 6
chr2_+_25180737 6.702 ENSMUST00000104999.2
 Nrarp
Notch-regulated ankyrin repeat protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 147 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.7 20.0 GO:0035790 platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790)
5.3 16.0 GO:0021759 globus pallidus development(GO:0021759)
3.9 15.8 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
1.2 12.4 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
1.9 11.3 GO:0032488 Cdc42 protein signal transduction(GO:0032488)
2.0 10.2 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
1.2 9.9 GO:1902947 regulation of tau-protein kinase activity(GO:1902947)
0.6 9.5 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 8.5 GO:0030500 regulation of bone mineralization(GO:0030500)
0.4 8.3 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.0 8.3 GO:0042060 wound healing(GO:0042060)
2.7 8.2 GO:0072076 hyaluranon cable assembly(GO:0036118) nephrogenic mesenchyme development(GO:0072076) negative regulation of glomerular mesangial cell proliferation(GO:0072125) negative regulation of glomerulus development(GO:0090194) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
2.0 8.2 GO:0060686 negative regulation of prostatic bud formation(GO:0060686)
1.0 8.0 GO:0048625 myoblast fate commitment(GO:0048625)
0.4 8.0 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.2 7.6 GO:0007638 mechanosensory behavior(GO:0007638)
2.5 7.4 GO:0090258 negative regulation of mitochondrial fission(GO:0090258)
2.4 7.3 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
2.4 7.3 GO:1902524 negative regulation of interferon-alpha production(GO:0032687) interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) negative regulation of interferon-beta biosynthetic process(GO:0045358) positive regulation of protein K48-linked ubiquitination(GO:1902524)
1.5 7.3 GO:0050847 progesterone receptor signaling pathway(GO:0050847)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 42.6 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 25.7 GO:0005667 transcription factor complex(GO:0005667)
0.3 21.3 GO:0005902 microvillus(GO:0005902)
0.1 13.8 GO:0030426 growth cone(GO:0030426)
3.1 12.4 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.3 11.7 GO:0005719 nuclear euchromatin(GO:0005719)
0.2 11.5 GO:0031225 anchored component of membrane(GO:0031225)
0.0 11.3 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 9.7 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 9.6 GO:0043197 dendritic spine(GO:0043197)
0.1 8.6 GO:0005901 caveola(GO:0005901)
0.1 8.2 GO:0031012 extracellular matrix(GO:0031012)
0.9 8.0 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 7.7 GO:0016324 apical plasma membrane(GO:0016324)
0.1 7.1 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.2 6.9 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 5.6 GO:0005635 nuclear envelope(GO:0005635)
1.2 4.8 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
0.3 4.7 GO:0042555 MCM complex(GO:0042555)
0.5 4.6 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 106 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.0 20.0 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
1.3 16.1 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.0 15.1 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
2.6 10.6 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.5 9.9 GO:0042056 chemoattractant activity(GO:0042056)
0.4 9.8 GO:0045295 gamma-catenin binding(GO:0045295)
0.3 8.3 GO:0001786 phosphatidylserine binding(GO:0001786)
1.6 8.2 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.8 8.2 GO:0070700 BMP receptor binding(GO:0070700)
0.1 7.5 GO:0005178 integrin binding(GO:0005178)
2.5 7.4 GO:0008502 melatonin receptor activity(GO:0008502)
0.4 7.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.3 7.2 GO:0070410 co-SMAD binding(GO:0070410)
1.1 6.7 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
1.3 6.4 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.2 6.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.3 6.2 GO:0017081 chloride channel regulator activity(GO:0017081)
0.2 5.9 GO:0005109 frizzled binding(GO:0005109)
0.6 5.8 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.3 5.8 GO:0005521 lamin binding(GO:0005521)