Motif ID: Foxc2

Z-value: 0.342


Transcription factors associated with Foxc2:

Gene SymbolEntrez IDGene Name
Foxc2 ENSMUSG00000046714.6 Foxc2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxc2mm10_v2_chr8_+_121116163_121116177-0.502.8e-03Click!


Activity profile for motif Foxc2.

activity profile for motif Foxc2


Sorted Z-values histogram for motif Foxc2

Sorted Z-values for motif Foxc2



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxc2

PNG image of the network

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Top targets:


Showing 1 to 20 of 113 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_84773381 3.823 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr2_-_62483637 1.948 ENSMUST00000136686.1
ENSMUST00000102733.3
 Gcg

glucagon

chr11_+_32000452 1.940 ENSMUST00000020537.2
ENSMUST00000109409.1
 Nsg2

neuron specific gene family member 2

chr9_+_53850243 1.700 ENSMUST00000048485.5
 Sln
sarcolipin
chr1_+_177444653 1.681 ENSMUST00000094276.3
 Zbtb18
zinc finger and BTB domain containing 18
chr4_-_87806296 1.560 ENSMUST00000126353.1
ENSMUST00000149357.1
 Mllt3

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

chr3_-_123672321 1.379 ENSMUST00000172537.1
ENSMUST00000029602.6
 Ndst3

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3

chr16_-_74411292 1.353 ENSMUST00000117200.1
 Robo2
roundabout homolog 2 (Drosophila)
chr4_+_97777606 1.318 ENSMUST00000075448.6
ENSMUST00000092532.6
 Nfia

nuclear factor I/A

chr4_+_48049080 1.314 ENSMUST00000153369.1
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr12_-_108003414 1.304 ENSMUST00000109887.1
ENSMUST00000109891.2
 Bcl11b

B cell leukemia/lymphoma 11B

chr11_+_32000496 1.179 ENSMUST00000093219.3
 Nsg2
neuron specific gene family member 2
chr12_-_108003594 1.123 ENSMUST00000066060.4
 Bcl11b
B cell leukemia/lymphoma 11B
chr2_-_45110336 0.946 ENSMUST00000028229.6
ENSMUST00000152232.1
 Zeb2

zinc finger E-box binding homeobox 2

chr7_+_44849581 0.891 ENSMUST00000150335.1
ENSMUST00000107882.1
 Akt1s1

AKT1 substrate 1 (proline-rich)

chr8_+_45658666 0.872 ENSMUST00000134675.1
ENSMUST00000139869.1
ENSMUST00000126067.1
 Sorbs2


sorbin and SH3 domain containing 2


chr2_-_73312701 0.856 ENSMUST00000058615.9
 Cir1
corepressor interacting with RBPJ, 1
chr17_+_70522083 0.797 ENSMUST00000148486.1
ENSMUST00000133717.1
 Dlgap1

discs, large (Drosophila) homolog-associated protein 1

chr17_+_3532554 0.785 ENSMUST00000168560.1
 Cldn20
claudin 20
chrX_+_163911401 0.768 ENSMUST00000140845.1
 Ap1s2
adaptor-related protein complex 1, sigma 2 subunit

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 3.8 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.1 3.1 GO:0048268 clathrin coat assembly(GO:0048268)
0.4 2.4 GO:0021773 striatal medium spiny neuron differentiation(GO:0021773)
0.1 2.2 GO:0045792 negative regulation of cell size(GO:0045792)
0.2 2.1 GO:0007379 segment specification(GO:0007379)
0.3 1.9 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072366)
0.4 1.7 GO:1901894 regulation of calcium-transporting ATPase activity(GO:1901894)
0.0 1.7 GO:0021766 hippocampus development(GO:0021766)
0.0 1.6 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.5 1.4 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.4 1.3 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
0.1 1.2 GO:0070842 aggresome assembly(GO:0070842)
0.0 1.1 GO:0060074 synapse maturation(GO:0060074)
0.2 0.9 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.0 0.8 GO:0036465 synaptic vesicle recycling(GO:0036465)
0.2 0.7 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244)
0.2 0.7 GO:0042998 positive regulation of Golgi to plasma membrane protein transport(GO:0042998)
0.1 0.7 GO:0061368 behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.1 0.7 GO:0009404 toxin metabolic process(GO:0009404)
0.0 0.7 GO:0050919 negative chemotaxis(GO:0050919)

Gene overrepresentation in cellular_component category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.6 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.2 2.2 GO:0031931 TORC1 complex(GO:0031931)
0.0 2.1 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 1.7 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 1.7 GO:0045171 intercellular bridge(GO:0045171)
0.0 1.4 GO:0030673 axolemma(GO:0030673)
0.0 0.8 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 0.7 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.7 GO:0030667 secretory granule membrane(GO:0030667)
0.0 0.6 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.5 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 0.5 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.5 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.3 GO:0000145 exocyst(GO:0000145)
0.0 0.2 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.2 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 0.1 GO:0070688 MLL5-L complex(GO:0070688)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 3.1 GO:0032051 clathrin light chain binding(GO:0032051)
0.0 1.9 GO:0005179 hormone activity(GO:0005179)
0.2 1.4 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 1.3 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.9 GO:0070412 R-SMAD binding(GO:0070412)
0.1 0.8 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.2 0.7 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.1 0.7 GO:0071253 connexin binding(GO:0071253)
0.1 0.7 GO:0033192 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.6 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.0 0.6 GO:0031402 sodium ion binding(GO:0031402)
0.0 0.6 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 0.5 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.1 0.5 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.5 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.5 GO:0042287 MHC protein binding(GO:0042287)
0.0 0.4 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 0.3 GO:0016015 morphogen activity(GO:0016015)
0.1 0.3 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.3 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)