Motif ID: Foxi1_Foxo1

Z-value: 2.127

Transcription factors associated with Foxi1_Foxo1:

Gene SymbolEntrez IDGene Name
Foxi1 ENSMUSG00000047861.2 Foxi1
Foxo1 ENSMUSG00000044167.5 Foxo1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxo1mm10_v2_chr3_+_52268337_522683880.115.3e-01Click!


Activity profile for motif Foxi1_Foxo1.

activity profile for motif Foxi1_Foxo1


Sorted Z-values histogram for motif Foxi1_Foxo1

Sorted Z-values for motif Foxi1_Foxo1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxi1_Foxo1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 40.013 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr11_+_32276400 22.507 ENSMUST00000020531.2
 Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
chr17_-_70851710 21.569 ENSMUST00000166395.2
 Tgif1
TGFB-induced factor homeobox 1
chr12_-_56535047 16.806 ENSMUST00000178477.2
 Nkx2-1
NK2 homeobox 1
chr12_+_109452833 15.961 ENSMUST00000056110.8
 Dlk1
delta-like 1 homolog (Drosophila)
chr11_-_102365111 15.589 ENSMUST00000006749.9
 Slc4a1
solute carrier family 4 (anion exchanger), member 1
chr5_-_138170992 13.485 ENSMUST00000139983.1
 Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
chr7_-_37773555 13.159 ENSMUST00000176534.1
 Zfp536
zinc finger protein 536
chr18_-_47333311 12.663 ENSMUST00000126684.1
ENSMUST00000156422.1
 Sema6a

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

chr4_+_65124174 12.298 ENSMUST00000084501.3
 Pappa
pregnancy-associated plasma protein A
chr17_+_47505117 12.179 ENSMUST00000183044.1
ENSMUST00000037333.10
 Ccnd3

cyclin D3

chr3_+_134236483 11.683 ENSMUST00000181904.1
ENSMUST00000053048.9
 Cxxc4

CXXC finger 4

chr19_+_55741810 11.553 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
 Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr5_-_138171248 11.375 ENSMUST00000153867.1
 Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
chr17_+_47505149 10.890 ENSMUST00000183177.1
ENSMUST00000182848.1
 Ccnd3

cyclin D3

chrX_-_141725181 10.649 ENSMUST00000067841.7
 Irs4
insulin receptor substrate 4
chr17_+_47505043 10.495 ENSMUST00000182129.1
ENSMUST00000171031.1
 Ccnd3

cyclin D3

chr7_-_103853199 10.433 ENSMUST00000033229.3
 Hbb-y
hemoglobin Y, beta-like embryonic chain
chr15_+_3270767 10.325 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr9_+_78615501 9.775 ENSMUST00000093812.4
 Cd109
CD109 antigen

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 526 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 41.9 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
6.7 40.0 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
6.6 32.9 GO:0015671 oxygen transport(GO:0015671)
2.5 32.4 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
3.1 27.7 GO:0048619 embryonic hindgut morphogenesis(GO:0048619)
1.6 25.6 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.7 21.5 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.8 17.4 GO:0006270 DNA replication initiation(GO:0006270)
5.6 16.8 GO:0021759 globus pallidus development(GO:0021759)
0.9 15.6 GO:0046685 response to arsenic-containing substance(GO:0046685)
1.3 13.0 GO:0061032 visceral serous pericardium development(GO:0061032)
0.6 12.7 GO:2001224 positive regulation of neuron migration(GO:2001224)
4.0 12.1 GO:0045659 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
2.4 11.9 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
1.7 11.7 GO:0001887 selenium compound metabolic process(GO:0001887)
0.8 11.0 GO:2000739 regulation of mesenchymal stem cell differentiation(GO:2000739)
3.6 10.7 GO:0045819 positive regulation of glycogen catabolic process(GO:0045819)
0.9 10.4 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.7 10.3 GO:0048642 negative regulation of skeletal muscle tissue development(GO:0048642)
0.3 10.1 GO:0042168 heme metabolic process(GO:0042168)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 222 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 49.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 38.1 GO:0009897 external side of plasma membrane(GO:0009897)
2.5 36.9 GO:0042555 MCM complex(GO:0042555)
4.2 33.5 GO:0005833 hemoglobin complex(GO:0005833)
0.1 30.8 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 26.5 GO:0005667 transcription factor complex(GO:0005667)
0.3 23.7 GO:0072562 blood microparticle(GO:0072562)
0.3 22.5 GO:0005902 microvillus(GO:0005902)
2.3 20.6 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 17.0 GO:0005925 focal adhesion(GO:0005925)
0.2 15.8 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.1 13.8 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 13.8 GO:0005615 extracellular space(GO:0005615)
0.1 13.6 GO:0031012 extracellular matrix(GO:0031012)
0.1 12.9 GO:0031225 anchored component of membrane(GO:0031225)
0.1 10.6 GO:0031513 nonmotile primary cilium(GO:0031513)
2.1 10.5 GO:0097149 centralspindlin complex(GO:0097149)
1.7 9.9 GO:0001674 female germ cell nucleus(GO:0001674)
0.6 9.4 GO:0043196 varicosity(GO:0043196)
0.2 9.2 GO:0030118 clathrin coat(GO:0030118)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 370 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 53.4 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.8 39.2 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.8 38.8 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
6.6 32.9 GO:0005344 oxygen transporter activity(GO:0005344)
1.2 30.5 GO:0008432 JUN kinase binding(GO:0008432)
0.1 22.5 GO:0051015 actin filament binding(GO:0051015)
0.8 19.5 GO:0030506 ankyrin binding(GO:0030506)
0.2 18.0 GO:0005178 integrin binding(GO:0005178)
1.2 17.3 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
1.4 16.9 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.7 16.8 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.3 15.1 GO:0005158 insulin receptor binding(GO:0005158)
0.7 14.4 GO:0045295 gamma-catenin binding(GO:0045295)
0.1 14.3 GO:0003735 structural constituent of ribosome(GO:0003735)
1.2 12.9 GO:0015250 water channel activity(GO:0015250)
0.2 12.0 GO:0008186 ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.7 11.7 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.7 10.8 GO:0005537 mannose binding(GO:0005537)
0.5 10.8 GO:0017049 GTP-Rho binding(GO:0017049)
3.6 10.7 GO:0000402 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)