Motif ID: Foxo4

Z-value: 0.799


Transcription factors associated with Foxo4:

Gene SymbolEntrez IDGene Name
Foxo4 ENSMUSG00000042903.7 Foxo4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxo4mm10_v2_chrX_+_101254528_1012545740.212.5e-01Click!


Activity profile for motif Foxo4.

activity profile for motif Foxo4


Sorted Z-values histogram for motif Foxo4

Sorted Z-values for motif Foxo4



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxo4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_5796924 4.493 ENSMUST00000174808.1
Malat1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chr8_-_105943382 2.597 ENSMUST00000038896.7
Lcat
lecithin cholesterol acyltransferase
chr5_-_70842617 2.493 ENSMUST00000031119.1
Gabrg1
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1
chr15_-_97767798 1.830 ENSMUST00000129223.2
ENSMUST00000126854.2
ENSMUST00000135080.1
Rapgef3


Rap guanine nucleotide exchange factor (GEF) 3


chr8_-_45410539 1.761 ENSMUST00000034056.4
ENSMUST00000167106.1
Tlr3

toll-like receptor 3

chr17_+_78508063 1.607 ENSMUST00000024880.9
Vit
vitrin
chr14_-_25903100 1.587 ENSMUST00000052286.8
Plac9a
placenta specific 9a
chr14_-_26182480 1.562 ENSMUST00000184142.1
Plac9b
placenta specific 9b
chr2_-_175931051 1.524 ENSMUST00000108949.2
ENSMUST00000109018.2
Gm8898

predicted gene 8898

chr2_-_175141999 1.504 ENSMUST00000109062.1
ENSMUST00000109059.1
ENSMUST00000109060.1
Gm14399


predicted gene 14399


chr10_-_53638269 1.386 ENSMUST00000164393.1
Fam184a
family with sequence similarity 184, member A
chr2_-_175338197 1.319 ENSMUST00000121393.2
Gm4631
predicted gene 4631
chr2_+_176521056 1.261 ENSMUST00000108997.2
ENSMUST00000178443.1
Gm14431

predicted gene 14431

chr2_+_175469985 1.256 ENSMUST00000109042.3
ENSMUST00000109002.2
ENSMUST00000109043.2
ENSMUST00000143490.1
Gm8923



predicted gene 8923



chr11_+_101246960 1.240 ENSMUST00000107282.3
Ramp2
receptor (calcitonin) activity modifying protein 2
chr2_-_177957239 1.222 ENSMUST00000108928.1
ENSMUST00000108932.1
ENSMUST00000108930.2
Gm14326


predicted gene 14326


chr2_+_175372436 1.213 ENSMUST00000131676.1
ENSMUST00000109048.2
ENSMUST00000109047.2
Gm4723


predicted gene 4723


chr4_-_97778042 1.193 ENSMUST00000146447.1
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr2_-_175703646 1.176 ENSMUST00000109027.2
ENSMUST00000179061.1
ENSMUST00000131041.1
Gm4245


predicted gene 4245


chr18_-_38918642 1.172 ENSMUST00000040647.4
Fgf1
fibroblast growth factor 1
chr6_+_95117740 1.047 ENSMUST00000032107.7
ENSMUST00000119582.1
Kbtbd8

kelch repeat and BTB (POZ) domain containing 8

chr2_-_175206899 1.042 ENSMUST00000109055.1
ENSMUST00000099028.3
ENSMUST00000109056.1
ENSMUST00000109058.2
Gm14391



predicted gene 14391



chr2_+_178023284 1.026 ENSMUST00000108925.3
ENSMUST00000108926.2
Etohi1

ethanol induced 1

chr2_+_176670522 1.019 ENSMUST00000121956.1
ENSMUST00000108985.2
Gm14306

predicted gene 14306

chr2_-_177840318 0.961 ENSMUST00000108939.2
ENSMUST00000150650.1
Gm14325

predicted gene 14325

chr4_+_45972233 0.920 ENSMUST00000102929.1
Tdrd7
tudor domain containing 7
chr8_+_79639618 0.920 ENSMUST00000173078.1
ENSMUST00000173286.1
Otud4

OTU domain containing 4

chr11_-_77078404 0.902 ENSMUST00000102494.1
Ccdc55
coiled-coil domain containing 55
chrX_-_166585679 0.899 ENSMUST00000000412.2
Egfl6
EGF-like-domain, multiple 6
chr2_+_177000956 0.855 ENSMUST00000108975.2
ENSMUST00000156844.1
Gm14419

predicted gene 14419

chr12_+_75308308 0.838 ENSMUST00000118602.1
ENSMUST00000118966.1
ENSMUST00000055390.5
Rhoj


ras homolog gene family, member J


chr7_-_4524229 0.836 ENSMUST00000154913.1
Tnni3
troponin I, cardiac 3
chr2_+_176226569 0.829 ENSMUST00000099009.2
ENSMUST00000136719.1
2210418O10Rik

RIKEN cDNA 2210418O10 gene

chrX_+_85574018 0.804 ENSMUST00000048250.3
ENSMUST00000137438.1
ENSMUST00000146063.1
Tab3


TGF-beta activated kinase 1/MAP3K7 binding protein 3


chr2_+_175965331 0.795 ENSMUST00000109007.1
ENSMUST00000174416.1
Gm2026

predicted gene 2026

chr4_+_97777606 0.793 ENSMUST00000075448.6
ENSMUST00000092532.6
Nfia

nuclear factor I/A

chr8_+_26119361 0.793 ENSMUST00000014022.8
ENSMUST00000153528.1
ENSMUST00000131138.1
ENSMUST00000110575.1
Rnf170



ring finger protein 170



chr2_+_175869219 0.792 ENSMUST00000109011.1
Gm6710
predicted gene 6710
chr11_-_85139939 0.762 ENSMUST00000108075.2
Usp32
ubiquitin specific peptidase 32
chr7_-_89517576 0.717 ENSMUST00000041761.5
Prss23
protease, serine, 23
chr2_-_178078425 0.708 ENSMUST00000108924.2
ENSMUST00000131702.1
ENSMUST00000108923.1
Zfp931


zinc finger protein 931


chr1_+_6487231 0.701 ENSMUST00000140079.1
ENSMUST00000131494.1
St18

suppression of tumorigenicity 18

chr2_+_176798612 0.695 ENSMUST00000118012.2
Gm14295
predicted gene 14295
chr2_+_176708328 0.688 ENSMUST00000108981.2
ENSMUST00000108980.2
Gm14305

predicted gene 14305

chr2_-_176927809 0.680 ENSMUST00000099007.2
Gm14296
predicted gene 14296
chr2_-_75938407 0.669 ENSMUST00000099996.3
Ttc30b
tetratricopeptide repeat domain 30B
chr2_-_176636318 0.665 ENSMUST00000108990.2
ENSMUST00000119149.1
ENSMUST00000117267.1
Gm14308


predicted gene 14308


chr2_-_175435782 0.658 ENSMUST00000152941.1
ENSMUST00000109045.2
Gm4724

predicted gene 4724

chr2_-_176486773 0.640 ENSMUST00000120959.1
ENSMUST00000120521.1
Gm14434

predicted gene 14434

chr11_+_105589970 0.607 ENSMUST00000168598.1
ENSMUST00000100330.3
Tanc2

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2

chr17_-_23745829 0.568 ENSMUST00000046525.8
Kremen2
kringle containing transmembrane protein 2
chr8_+_26119611 0.554 ENSMUST00000140819.1
Rnf170
ring finger protein 170
chr4_-_32950813 0.530 ENSMUST00000084750.1
ENSMUST00000084748.2
Ankrd6

ankyrin repeat domain 6

chr2_-_45110336 0.523 ENSMUST00000028229.6
ENSMUST00000152232.1
Zeb2

zinc finger E-box binding homeobox 2

chr2_-_177206421 0.508 ENSMUST00000108964.1
Gm14410
predicted gene 14410
chr7_-_4778141 0.437 ENSMUST00000094892.5
Il11
interleukin 11
chr12_-_69892989 0.371 ENSMUST00000110567.1
ENSMUST00000171211.1
Map4k5

mitogen-activated protein kinase kinase kinase kinase 5

chr4_+_8690399 0.362 ENSMUST00000127476.1
Chd7
chromodomain helicase DNA binding protein 7
chr13_-_117025505 0.344 ENSMUST00000022239.6
Parp8
poly (ADP-ribose) polymerase family, member 8
chr11_-_102579461 0.336 ENSMUST00000107081.1
Gm11627
predicted gene 11627
chr18_-_6490808 0.298 ENSMUST00000028100.6
ENSMUST00000050542.5
Epc1

enhancer of polycomb homolog 1 (Drosophila)

chr8_+_70234613 0.271 ENSMUST00000145078.1
Sugp2
SURP and G patch domain containing 2
chr18_+_11839220 0.264 ENSMUST00000171109.1
ENSMUST00000046948.8
Cables1

CDK5 and Abl enzyme substrate 1

chr1_-_133131782 0.183 ENSMUST00000180528.1
Gm26616
predicted gene, 26616
chr11_-_42182924 0.180 ENSMUST00000020707.5
ENSMUST00000132971.1
Gabra1

gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1

chr2_-_144011202 0.178 ENSMUST00000016072.5
ENSMUST00000037875.5
Rrbp1

ribosome binding protein 1

chr6_+_56714891 0.176 ENSMUST00000031805.8
Avl9
AVL9 homolog (S. cerevisiase)
chr7_-_139582790 0.174 ENSMUST00000106095.2
Nkx6-2
NK6 homeobox 2
chr3_+_107895916 0.135 ENSMUST00000172247.1
ENSMUST00000167387.1
Gstm5

glutathione S-transferase, mu 5

chr15_-_102625436 0.126 ENSMUST00000184485.1
ENSMUST00000185070.1
ENSMUST00000184616.1
ENSMUST00000108828.2
ATF7



Cyclic AMP-dependent transcription factor ATF-7



chr7_-_133123770 0.124 ENSMUST00000164896.1
ENSMUST00000171968.1
Ctbp2

C-terminal binding protein 2

chr17_-_51831884 0.114 ENSMUST00000124222.1
Satb1
special AT-rich sequence binding protein 1
chr17_+_80944611 0.111 ENSMUST00000025092.4
Tmem178
transmembrane protein 178
chr5_-_135545108 0.102 ENSMUST00000060311.8
Hip1
huntingtin interacting protein 1
chr4_-_6454262 0.100 ENSMUST00000029910.5
Nsmaf
neutral sphingomyelinase (N-SMase) activation associated factor
chr6_+_42286676 0.089 ENSMUST00000031894.6
Clcn1
chloride channel 1
chr15_-_35938009 0.075 ENSMUST00000156915.1
Cox6c
cytochrome c oxidase subunit VIc
chr14_+_32028989 0.069 ENSMUST00000022460.4
Galnt15
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15
chr10_-_83337440 0.069 ENSMUST00000126617.1
Slc41a2
solute carrier family 41, member 2
chr5_-_90366176 0.058 ENSMUST00000014421.8
ENSMUST00000081914.6
ENSMUST00000168058.2
Ankrd17


ankyrin repeat domain 17


chr2_+_181767283 0.048 ENSMUST00000108757.2
Myt1
myelin transcription factor 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.5 GO:0035063 nuclear speck organization(GO:0035063)
0.6 1.8 GO:0045349 regulation of dendritic cell cytokine production(GO:0002730) interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of interferon-beta biosynthetic process(GO:0045359)
0.5 2.6 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372)
0.5 1.8 GO:1904451 regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904451) positive regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904453)
0.4 1.2 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.1 0.8 GO:0001980 regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980)
0.1 1.2 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.1 0.4 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.1 2.7 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1 0.5 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.1 0.8 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0 0.5 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 0.9 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.9 GO:0070306 lens fiber cell differentiation(GO:0070306)
0.0 0.1 GO:0039530 MDA-5 signaling pathway(GO:0039530)
0.0 0.2 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.0 0.8 GO:0060074 synapse maturation(GO:0060074)
0.0 2.5 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 0.1 GO:0070458 detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458)
0.0 0.3 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.1 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 0.7 GO:0042073 intraciliary transport(GO:0042073)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.8 GO:1990795 lateral part of cell(GO:0097574) basolateral part of cell(GO:1990794) rod bipolar cell terminal bouton(GO:1990795)
0.2 0.8 GO:0005861 troponin complex(GO:0005861)
0.1 2.7 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1 2.6 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.1 0.9 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.1 1.6 GO:0005614 interstitial matrix(GO:0005614)
0.1 0.3 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.7 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 2.7 GO:0016607 nuclear speck(GO:0016607)
0.0 1.0 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.6 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.3 0.8 GO:0030172 troponin C binding(GO:0030172)
0.2 1.8 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1 2.7 GO:0004890 GABA-A receptor activity(GO:0004890)
0.1 1.2 GO:0044548 S100 protein binding(GO:0044548)
0.1 1.2 GO:0015026 coreceptor activity(GO:0015026)
0.0 0.1 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.0 1.8 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.4 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.3 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.5 GO:0070412 R-SMAD binding(GO:0070412)