Motif ID: Gata2_Gata1

Z-value: 1.589

Transcription factors associated with Gata2_Gata1:

Gene SymbolEntrez IDGene Name
Gata1 ENSMUSG00000031162.8 Gata1
Gata2 ENSMUSG00000015053.8 Gata2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gata2mm10_v2_chr6_+_88198656_881986750.831.8e-09Click!
Gata1mm10_v2_chrX_-_7967817_79679100.827.5e-09Click!


Activity profile for motif Gata2_Gata1.

activity profile for motif Gata2_Gata1


Sorted Z-values histogram for motif Gata2_Gata1

Sorted Z-values for motif Gata2_Gata1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gata2_Gata1

PNG image of the network

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Top targets:


Showing 1 to 20 of 159 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_32276400 39.139 ENSMUST00000020531.2
 Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
chr11_+_32276893 34.261 ENSMUST00000145569.1
 Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
chr7_-_99238564 12.796 ENSMUST00000064231.7
 Mogat2
monoacylglycerol O-acyltransferase 2
chr3_-_154330543 12.600 ENSMUST00000184966.1
ENSMUST00000177846.2
 Lhx8

LIM homeobox protein 8

chr3_+_135825788 11.568 ENSMUST00000167390.1
 Slc39a8
solute carrier family 39 (metal ion transporter), member 8
chrX_+_150547375 10.392 ENSMUST00000066337.6
ENSMUST00000112715.1
 Alas2

aminolevulinic acid synthase 2, erythroid

chr19_-_42202150 10.361 ENSMUST00000018966.7
 Sfrp5
secreted frizzled-related sequence protein 5
chr17_+_36869567 9.076 ENSMUST00000060524.9
 Trim10
tripartite motif-containing 10
chr1_+_45311538 8.670 ENSMUST00000087883.6
 Col3a1
collagen, type III, alpha 1
chr9_-_32541589 8.569 ENSMUST00000016231.7
 Fli1
Friend leukemia integration 1
chr7_-_139582790 8.379 ENSMUST00000106095.2
 Nkx6-2
NK6 homeobox 2
chr13_+_38345716 7.751 ENSMUST00000171970.1
 Bmp6
bone morphogenetic protein 6
chr17_-_84682932 7.579 ENSMUST00000066175.3
 Abcg5
ATP-binding cassette, sub-family G (WHITE), member 5
chr2_-_153241402 7.431 ENSMUST00000056924.7
 Plagl2
pleiomorphic adenoma gene-like 2
chr4_-_46404224 6.882 ENSMUST00000107764.2
 Hemgn
hemogen
chr6_+_30541582 6.586 ENSMUST00000096066.4
 Cpa2
carboxypeptidase A2, pancreatic
chr9_-_44342332 6.425 ENSMUST00000097558.3
 Hmbs
hydroxymethylbilane synthase
chr7_-_4522427 6.288 ENSMUST00000098859.3
 Tnni3
troponin I, cardiac 3
chrX_-_107403295 6.159 ENSMUST00000033591.5
 Itm2a
integral membrane protein 2A
chr4_-_59438633 6.143 ENSMUST00000040166.7
ENSMUST00000107544.1
 Susd1

sushi domain containing 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
14.7 73.4 GO:0015671 oxygen transport(GO:0015671)
0.6 18.1 GO:0006783 heme biosynthetic process(GO:0006783)
1.8 17.6 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
1.4 12.9 GO:0006071 glycerol metabolic process(GO:0006071)
0.2 12.6 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
1.7 12.1 GO:0060586 multicellular organismal iron ion homeostasis(GO:0060586)
1.8 10.8 GO:0042866 pyruvate biosynthetic process(GO:0042866)
3.5 10.4 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
1.7 10.1 GO:0001980 regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980)
1.7 8.7 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.4 8.6 GO:0035855 megakaryocyte development(GO:0035855)
1.2 8.4 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.5 8.0 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.1 8.0 GO:0030168 platelet activation(GO:0030168)
2.5 7.6 GO:0030300 regulation of intestinal cholesterol absorption(GO:0030300)
0.5 7.4 GO:0034377 plasma lipoprotein particle assembly(GO:0034377)
0.5 7.2 GO:0046697 decidualization(GO:0046697)
1.0 6.2 GO:0002317 plasma cell differentiation(GO:0002317) negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.6 5.9 GO:0034242 negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
0.8 5.0 GO:0060842 arterial endothelial cell differentiation(GO:0060842)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
9.2 73.4 GO:0005833 hemoglobin complex(GO:0005833)
2.1 12.6 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 10.4 GO:0005759 mitochondrial matrix(GO:0005759)
2.0 10.1 GO:0005861 troponin complex(GO:0005861)
0.7 8.7 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.8 7.6 GO:0098533 ATPase dependent transmembrane transport complex(GO:0098533)
0.4 6.1 GO:0031528 microvillus membrane(GO:0031528)
0.0 5.9 GO:0000790 nuclear chromatin(GO:0000790)
0.0 5.5 GO:0000793 condensed chromosome(GO:0000793)
0.0 5.4 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 5.0 GO:0043204 perikaryon(GO:0043204)
0.9 4.5 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 4.3 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 3.8 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 3.7 GO:0031965 nuclear membrane(GO:0031965)
0.1 3.6 GO:0002102 podosome(GO:0002102)
0.2 3.4 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.3 3.3 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 3.0 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.2 2.0 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
14.7 73.4 GO:0005344 oxygen transporter activity(GO:0005344)
0.7 17.6 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 13.8 GO:0008270 zinc ion binding(GO:0008270)
4.3 12.8 GO:0003846 2-acylglycerol O-acyltransferase activity(GO:0003846)
3.6 10.8 GO:0004743 pyruvate kinase activity(GO:0004743)
0.6 10.4 GO:0016594 glycine binding(GO:0016594)
0.5 10.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
3.4 10.1 GO:0030172 troponin C binding(GO:0030172)
0.6 8.7 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 8.6 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 8.5 GO:0003682 chromatin binding(GO:0003682)
0.0 8.0 GO:0008022 protein C-terminus binding(GO:0008022)
0.8 7.8 GO:0070700 BMP receptor binding(GO:0070700)
0.4 6.6 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 6.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.1 6.4 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.1 6.4 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.2 6.2 GO:0001540 beta-amyloid binding(GO:0001540)
0.2 5.9 GO:0050699 WW domain binding(GO:0050699)
1.2 4.9 GO:0004921 interleukin-11 receptor activity(GO:0004921) interleukin-11 binding(GO:0019970)