Motif ID: Gbx1_Nobox_Alx3

Z-value: 0.701

Transcription factors associated with Gbx1_Nobox_Alx3:

Gene SymbolEntrez IDGene Name
Alx3 ENSMUSG00000014603.1 Alx3
Gbx1 ENSMUSG00000067724.4 Gbx1
Nobox ENSMUSG00000029736.9 Nobox

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Alx3mm10_v2_chr3_+_107595031_1075951640.593.5e-04Click!
Gbx1mm10_v2_chr5_-_24527276_245272760.382.8e-02Click!


Activity profile for motif Gbx1_Nobox_Alx3.

activity profile for motif Gbx1_Nobox_Alx3


Sorted Z-values histogram for motif Gbx1_Nobox_Alx3

Sorted Z-values for motif Gbx1_Nobox_Alx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Gbx1_Nobox_Alx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_62765618 4.884 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr2_+_109917639 4.621 ENSMUST00000046548.7
ENSMUST00000111037.2
 Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr2_-_168767029 4.513 ENSMUST00000075044.3
 Sall4
sal-like 4 (Drosophila)
chr3_+_159839729 4.345 ENSMUST00000068952.5
 Wls
wntless homolog (Drosophila)
chr18_+_23415400 3.942 ENSMUST00000115832.2
ENSMUST00000047954.7
 Dtna

dystrobrevin alpha

chr6_-_124779686 3.933 ENSMUST00000147669.1
ENSMUST00000128697.1
ENSMUST00000032218.3
ENSMUST00000112475.2
 Lrrc23



leucine rich repeat containing 23



chr15_+_25773985 3.651 ENSMUST00000125667.1
 Myo10
myosin X
chr12_+_38780284 3.453 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
 Etv1


ets variant gene 1


chr3_+_122419772 3.410 ENSMUST00000029766.4
 Bcar3
breast cancer anti-estrogen resistance 3
chr1_+_104768510 3.291 ENSMUST00000062528.8
 Cdh20
cadherin 20
chr13_-_102905740 3.263 ENSMUST00000167462.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr13_-_102906046 3.150 ENSMUST00000171791.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr2_+_152754156 3.140 ENSMUST00000010020.5
 Cox4i2
cytochrome c oxidase subunit IV isoform 2
chr18_+_56432116 3.103 ENSMUST00000070166.5
 Gramd3
GRAM domain containing 3
chr2_-_168767136 2.878 ENSMUST00000029061.5
ENSMUST00000103074.1
 Sall4

sal-like 4 (Drosophila)

chr5_-_62766153 2.798 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr15_-_37459327 2.782 ENSMUST00000119730.1
ENSMUST00000120746.1
 Ncald

neurocalcin delta

chr6_+_125552948 2.716 ENSMUST00000112254.1
ENSMUST00000112253.1
ENSMUST00000001995.7
 Vwf


Von Willebrand factor homolog


chr13_-_53473074 2.501 ENSMUST00000021922.8
 Msx2
msh homeobox 2
chr17_-_49564262 2.397 ENSMUST00000057610.6
 Daam2
dishevelled associated activator of morphogenesis 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 128 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 9.5 GO:0007638 mechanosensory behavior(GO:0007638)
0.4 7.4 GO:0001833 inner cell mass cell proliferation(GO:0001833)
1.5 4.6 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.6 4.6 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.3 4.3 GO:0031017 exocrine pancreas development(GO:0031017)
0.0 3.9 GO:0001889 liver development(GO:0001889)
0.1 3.4 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 3.4 GO:0008360 regulation of cell shape(GO:0008360)
1.1 3.2 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.0 3.2 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.5 3.1 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 3.1 GO:0030178 negative regulation of Wnt signaling pathway(GO:0030178)
0.1 2.8 GO:0050873 brown fat cell differentiation(GO:0050873)
0.8 2.5 GO:0048818 embryonic nail plate morphogenesis(GO:0035880) positive regulation of hair follicle maturation(GO:0048818) positive regulation of catagen(GO:0051795) frontal suture morphogenesis(GO:0060364)
0.1 2.4 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.1 2.3 GO:0045879 negative regulation of smoothened signaling pathway(GO:0045879)
0.6 2.2 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.2 2.2 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.1 2.2 GO:0006907 pinocytosis(GO:0006907)
0.4 2.1 GO:0045218 zonula adherens maintenance(GO:0045218)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.7 GO:0000792 heterochromatin(GO:0000792)
0.0 5.6 GO:0005667 transcription factor complex(GO:0005667)
0.3 5.2 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 4.3 GO:0032590 dendrite membrane(GO:0032590)
0.1 3.9 GO:0016459 myosin complex(GO:0016459)
0.0 3.4 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 3.3 GO:0016607 nuclear speck(GO:0016607)
0.4 3.1 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.5 2.7 GO:0033093 Weibel-Palade body(GO:0033093)
0.2 2.7 GO:0005915 zonula adherens(GO:0005915)
0.1 2.5 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 2.2 GO:0002102 podosome(GO:0002102)
0.1 2.1 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 2.0 GO:0005882 intermediate filament(GO:0005882)
0.0 1.8 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 1.6 GO:0043034 costamere(GO:0043034)
0.0 1.6 GO:0031201 SNARE complex(GO:0031201)
0.3 1.5 GO:0001674 female germ cell nucleus(GO:0001674)
0.3 1.4 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.1 1.4 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 103 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 18.3 GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982)
0.2 7.7 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 7.2 GO:0030165 PDZ domain binding(GO:0030165)
0.0 6.1 GO:0044212 transcription regulatory region DNA binding(GO:0044212)
0.0 5.4 GO:0000287 magnesium ion binding(GO:0000287)
0.5 5.1 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.7 4.6 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.4 4.6 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 3.9 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 3.8 GO:0003779 actin binding(GO:0003779)
0.1 3.6 GO:0030507 spectrin binding(GO:0030507)
0.4 3.2 GO:0050693 LBD domain binding(GO:0050693)
0.0 2.8 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.5 2.7 GO:0019865 immunoglobulin binding(GO:0019865)
0.1 2.5 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 2.4 GO:0070097 delta-catenin binding(GO:0070097)
0.3 2.0 GO:0015180 L-alanine transmembrane transporter activity(GO:0015180) L-proline transmembrane transporter activity(GO:0015193) alanine transmembrane transporter activity(GO:0022858)
0.2 1.9 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.2 1.9 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.1 1.9 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)