Motif ID: Gli1

Z-value: 0.478


Transcription factors associated with Gli1:

Gene SymbolEntrez IDGene Name
Gli1 ENSMUSG00000025407.6 Gli1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gli1mm10_v2_chr10_-_127341583_127341614-0.309.5e-02Click!


Activity profile for motif Gli1.

activity profile for motif Gli1


Sorted Z-values histogram for motif Gli1

Sorted Z-values for motif Gli1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gli1

PNG image of the network

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Top targets:


Showing 1 to 20 of 157 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_54954728 2.148 ENSMUST00000033915.7
 Gpm6a
glycoprotein m6a
chr11_-_42000284 1.946 ENSMUST00000109292.2
ENSMUST00000109290.1
 Gabrg2

gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2

chr11_+_80300866 1.706 ENSMUST00000017836.7
 Rhbdl3
rhomboid, veinlet-like 3 (Drosophila)
chr17_+_37045963 1.446 ENSMUST00000025338.9
 Gabbr1
gamma-aminobutyric acid (GABA) B receptor, 1
chr11_-_42000532 1.398 ENSMUST00000070735.3
 Gabrg2
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2
chr1_-_133801031 1.390 ENSMUST00000143567.1
 Atp2b4
ATPase, Ca++ transporting, plasma membrane 4
chr8_+_45658666 1.383 ENSMUST00000134675.1
ENSMUST00000139869.1
ENSMUST00000126067.1
 Sorbs2


sorbin and SH3 domain containing 2


chr2_-_29253001 1.381 ENSMUST00000071201.4
 Ntng2
netrin G2
chr3_+_45378396 1.381 ENSMUST00000166126.1
ENSMUST00000170695.1
ENSMUST00000171554.1
 Pcdh10


protocadherin 10


chr2_+_106693185 1.329 ENSMUST00000111063.1
 Mpped2
metallophosphoesterase domain containing 2
chr4_-_148130678 1.325 ENSMUST00000030862.4
 Draxin
dorsal inhibitory axon guidance protein
chr9_+_50752758 1.307 ENSMUST00000034562.7
 Cryab
crystallin, alpha B
chr1_+_152954966 1.287 ENSMUST00000043313.8
 Nmnat2
nicotinamide nucleotide adenylyltransferase 2
chr8_+_45658731 1.258 ENSMUST00000143820.1
ENSMUST00000132139.1
 Sorbs2

sorbin and SH3 domain containing 2

chr15_-_78544345 1.224 ENSMUST00000053239.2
 Sstr3
somatostatin receptor 3
chr2_+_70562007 1.218 ENSMUST00000094934.4
 Gad1
glutamate decarboxylase 1
chr15_-_100584075 1.209 ENSMUST00000184908.1
 POU6F1
POU domain, class 6, transcription factor 1 (Pou6f1), mRNA
chr2_-_54085542 1.207 ENSMUST00000100089.2
 Rprm
reprimo, TP53 dependent G2 arrest mediator candidate
chr4_+_11156411 1.191 ENSMUST00000029865.3
 Trp53inp1
transformation related protein 53 inducible nuclear protein 1
chr18_-_43373248 1.188 ENSMUST00000118043.1
 Dpysl3
dihydropyrimidinase-like 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.7 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.3 2.9 GO:0071420 cellular response to histamine(GO:0071420)
0.4 2.6 GO:0032811 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) negative regulation of epinephrine secretion(GO:0032811)
0.2 2.5 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 2.1 GO:0003407 neural retina development(GO:0003407)
0.3 1.9 GO:1900451 rhythmic synaptic transmission(GO:0060024) terminal button organization(GO:0072553) positive regulation of glutamate receptor signaling pathway(GO:1900451) positive regulation of protein localization to synapse(GO:1902474) positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000969)
0.5 1.4 GO:0045763 negative regulation of cellular amino acid metabolic process(GO:0045763)
0.0 1.4 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.3 1.3 GO:0019355 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process(GO:0034627) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.2 1.3 GO:0007021 tubulin complex assembly(GO:0007021)
0.1 1.3 GO:0021516 dorsal spinal cord development(GO:0021516)
0.2 1.2 GO:0030242 pexophagy(GO:0030242)
0.2 1.2 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.2 1.2 GO:0071361 autophagic cell death(GO:0048102) cellular response to ethanol(GO:0071361)
0.1 1.2 GO:0051764 actin crosslink formation(GO:0051764)
0.0 1.2 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.4 1.1 GO:0035864 response to potassium ion(GO:0035864) cellular response to potassium ion(GO:0035865)
0.1 1.0 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 0.9 GO:0048681 negative regulation of axon regeneration(GO:0048681)
0.1 0.9 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.4 GO:0060077 inhibitory synapse(GO:0060077)
0.5 2.6 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.1 2.5 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 2.5 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 2.2 GO:0060170 ciliary membrane(GO:0060170)
0.0 2.1 GO:0044295 axonal growth cone(GO:0044295)
0.1 1.4 GO:0097228 sperm principal piece(GO:0097228)
0.0 1.4 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.4 1.3 GO:0097512 cardiac myofibril(GO:0097512)
0.0 1.2 GO:0031941 filamentous actin(GO:0031941)
0.1 0.8 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.8 GO:0005871 kinesin complex(GO:0005871)
0.0 0.7 GO:0043194 axon initial segment(GO:0043194)
0.0 0.6 GO:0030673 axolemma(GO:0030673)
0.0 0.6 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 0.5 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.5 GO:0016459 myosin complex(GO:0016459)
0.1 0.4 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.4 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.4 GO:0031594 neuromuscular junction(GO:0031594)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.9 GO:0004890 GABA-A receptor activity(GO:0004890) GABA receptor activity(GO:0016917)
0.4 2.6 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.1 2.5 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 2.4 GO:0015085 calcium ion transmembrane transporter activity(GO:0015085)
0.1 1.9 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 1.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 1.4 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.3 1.3 GO:0004515 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.1 1.3 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 1.3 GO:0044824 integrase activity(GO:0008907) T/G mismatch-specific endonuclease activity(GO:0043765) retroviral integrase activity(GO:0044823) retroviral 3' processing activity(GO:0044824)
0.4 1.2 GO:0004994 somatostatin receptor activity(GO:0004994)
0.3 1.2 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.1 1.0 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 1.0 GO:0016209 antioxidant activity(GO:0016209)
0.1 0.9 GO:1990459 transferrin receptor binding(GO:1990459)
0.0 0.9 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.8 GO:0034945 dihydrolipoamide branched chain acyltransferase activity(GO:0004147) palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity(GO:0008951) serine O-acyltransferase activity(GO:0016412) C-palmitoyltransferase activity(GO:0016454) O-succinyltransferase activity(GO:0016750) sinapoyltransferase activity(GO:0016752) O-sinapoyltransferase activity(GO:0016753) peptidyl-lysine N6-myristoyltransferase activity(GO:0018030) peptidyl-lysine N6-palmitoyltransferase activity(GO:0018031) benzoyl acetate-CoA thiolase activity(GO:0018711) 3-hydroxybutyryl-CoA thiolase activity(GO:0018712) 3-ketopimelyl-CoA thiolase activity(GO:0018713) N-palmitoyltransferase activity(GO:0019105) acyl-CoA N-acyltransferase activity(GO:0019186) protein-cysteine S-myristoyltransferase activity(GO:0019705) glucosaminyl-phosphotidylinositol O-acyltransferase activity(GO:0032216) ergosterol O-acyltransferase activity(GO:0034737) lanosterol O-acyltransferase activity(GO:0034738) naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity(GO:0034848) 2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity(GO:0034851) 2-methylhexanoyl-CoA C-acetyltransferase activity(GO:0034915) butyryl-CoA 2-C-propionyltransferase activity(GO:0034919) 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity(GO:0034945) L-2-aminoadipate N-acetyltransferase activity(GO:0043741) keto acid formate lyase activity(GO:0043806) azetidine-2-carboxylic acid acetyltransferase activity(GO:0046941) peptidyl-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0052858) acetyl-CoA:L-lysine N6-acetyltransferase(GO:0090595)
0.0 0.8 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.8 GO:0003777 microtubule motor activity(GO:0003777)
0.1 0.7 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)