Motif ID: Gli2

Z-value: 0.462


Transcription factors associated with Gli2:

Gene SymbolEntrez IDGene Name
Gli2 ENSMUSG00000048402.8 Gli2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gli2mm10_v2_chr1_-_119053339_119053370-0.212.5e-01Click!


Activity profile for motif Gli2.

activity profile for motif Gli2


Sorted Z-values histogram for motif Gli2

Sorted Z-values for motif Gli2



Network of associatons between targets according to the STRING database.



First level regulatory network of Gli2

PNG image of the network

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Top targets:


Showing 1 to 20 of 127 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_120287349 2.525 ENSMUST00000102656.3
 Foxo6
forkhead box O6
chr19_+_5740885 1.673 ENSMUST00000081496.5
 Ltbp3
latent transforming growth factor beta binding protein 3
chr10_+_93589413 1.519 ENSMUST00000181835.1
 4933408J17Rik
RIKEN cDNA 4933408J17 gene
chr8_+_70754679 1.328 ENSMUST00000110093.2
ENSMUST00000143118.1
ENSMUST00000034301.5
ENSMUST00000110090.1
 Rab3a



RAB3A, member RAS oncogene family



chr12_+_58211772 1.275 ENSMUST00000110671.2
ENSMUST00000044299.2
 Sstr1

somatostatin receptor 1

chr11_-_118909487 1.240 ENSMUST00000117731.1
ENSMUST00000106278.2
ENSMUST00000120061.1
ENSMUST00000017576.4
 Rbfox3



RNA binding protein, fox-1 homolog (C. elegans) 3



chr3_+_105452326 1.213 ENSMUST00000098761.3
 Kcnd3
potassium voltage-gated channel, Shal-related family, member 3
chr7_-_121035096 1.198 ENSMUST00000065740.2
 Gm9905
predicted gene 9905
chr1_+_55406163 1.136 ENSMUST00000042986.8
 Plcl1
phospholipase C-like 1
chr15_-_78718113 1.114 ENSMUST00000088592.4
 Elfn2
leucine rich repeat and fibronectin type III, extracellular 2
chr5_-_71095765 1.025 ENSMUST00000000572.5
 Gabra2
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2
chr9_+_13662460 0.996 ENSMUST00000177755.1
 Maml2
mastermind like 2 (Drosophila)
chr3_+_107036156 0.970 ENSMUST00000052718.3
 Kcna3
potassium voltage-gated channel, shaker-related subfamily, member 3
chr13_-_54611274 0.875 ENSMUST00000049575.7
 Cltb
clathrin, light polypeptide (Lcb)
chr10_-_127263346 0.873 ENSMUST00000099172.3
 Kif5a
kinesin family member 5A
chr14_-_55116935 0.872 ENSMUST00000022819.5
 Jph4
junctophilin 4
chr3_+_127633134 0.847 ENSMUST00000029587.7
 Neurog2
neurogenin 2
chr2_-_127482499 0.840 ENSMUST00000088538.5
 Kcnip3
Kv channel interacting protein 3, calsenilin
chr11_-_42000284 0.837 ENSMUST00000109292.2
ENSMUST00000109290.1
 Gabrg2

gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2

chr18_-_35215008 0.834 ENSMUST00000091636.3
 Lrrtm2
leucine rich repeat transmembrane neuronal 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.6 1.7 GO:1902460 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.2 1.5 GO:0071420 cellular response to histamine(GO:0071420)
0.0 1.5 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
0.4 1.3 GO:0050975 sensory perception of touch(GO:0050975)
0.1 1.3 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.2 1.1 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.1 1.1 GO:0071435 potassium ion export(GO:0071435)
0.0 1.1 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.2 1.0 GO:0014054 positive regulation of gamma-aminobutyric acid secretion(GO:0014054)
0.1 1.0 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.1 1.0 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 1.0 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.8 GO:0048266 behavioral response to pain(GO:0048266)
0.0 0.8 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.2 0.7 GO:1904706 negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
0.1 0.7 GO:0051013 microtubule severing(GO:0051013)
0.1 0.7 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
0.0 0.7 GO:2000463 positive regulation of excitatory postsynaptic potential(GO:2000463)
0.2 0.6 GO:0070124 mitochondrial translational initiation(GO:0070124)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.6 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1 1.5 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 1.4 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 1.3 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 1.2 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 1.2 GO:0043204 perikaryon(GO:0043204)
0.2 0.9 GO:0030314 junctional membrane complex(GO:0030314)
0.1 0.9 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.9 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.8 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 0.5 GO:0032280 symmetric synapse(GO:0032280)
0.1 0.5 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 0.5 GO:0045095 keratin filament(GO:0045095)
0.1 0.3 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.2 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 0.2 GO:0032009 early phagosome(GO:0032009)
0.0 0.2 GO:0071203 WASH complex(GO:0071203)
0.0 0.2 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.1 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.0 0.1 GO:0005594 collagen type IX trimer(GO:0005594)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.6 GO:0004890 GABA-A receptor activity(GO:0004890)
0.1 1.7 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.2 1.5 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.1 1.4 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.4 1.3 GO:0004994 somatostatin receptor activity(GO:0004994)
0.1 1.3 GO:0031489 myosin V binding(GO:0031489)
0.2 1.2 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 1.1 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 1.0 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.1 0.9 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 0.8 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.8 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.8 GO:0070888 E-box binding(GO:0070888)
0.0 0.8 GO:0015459 potassium channel regulator activity(GO:0015459)
0.1 0.7 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0 0.7 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.0 0.6 GO:0017049 GTP-Rho binding(GO:0017049)
0.1 0.5 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 0.5 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.5 GO:0008188 neuropeptide receptor activity(GO:0008188)