Motif ID: Gli3_Zic1

Z-value: 1.473

Transcription factors associated with Gli3_Zic1:

Gene SymbolEntrez IDGene Name
Gli3 ENSMUSG00000021318.9 Gli3
Zic1 ENSMUSG00000032368.8 Zic1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gli3mm10_v2_chr13_+_15463837_15463980-0.383.1e-02Click!
Zic1mm10_v2_chr9_-_91365778_91365815-0.125.2e-01Click!


Activity profile for motif Gli3_Zic1.

activity profile for motif Gli3_Zic1


Sorted Z-values histogram for motif Gli3_Zic1

Sorted Z-values for motif Gli3_Zic1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gli3_Zic1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_91269759 10.981 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr9_+_50752758 7.913 ENSMUST00000034562.7
 Cryab
crystallin, alpha B
chr7_-_100656953 7.353 ENSMUST00000107046.1
ENSMUST00000107045.1
ENSMUST00000139708.1
 Plekhb1


pleckstrin homology domain containing, family B (evectins) member 1


chr4_-_148130678 7.091 ENSMUST00000030862.4
 Draxin
dorsal inhibitory axon guidance protein
chr10_-_127341583 6.831 ENSMUST00000026474.3
 Gli1
GLI-Kruppel family member GLI1
chr9_-_54661870 6.049 ENSMUST00000034822.5
 Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr4_-_68954351 5.954 ENSMUST00000030036.5
 Brinp1
bone morphogenic protein/retinoic acid inducible neural specific 1
chrX_-_16911774 5.893 ENSMUST00000040134.7
 Ndp
Norrie disease (pseudoglioma) (human)
chr9_-_54661666 5.779 ENSMUST00000128624.1
 Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr6_-_101377342 5.625 ENSMUST00000151175.1
 Pdzrn3
PDZ domain containing RING finger 3
chr8_-_105966038 5.582 ENSMUST00000116429.2
ENSMUST00000034370.9
 Slc12a4

solute carrier family 12, member 4

chr6_-_101377897 5.280 ENSMUST00000075994.6
 Pdzrn3
PDZ domain containing RING finger 3
chrX_+_101299143 4.971 ENSMUST00000118111.1
ENSMUST00000130555.1
ENSMUST00000151528.1
 Nlgn3


neuroligin 3


chr2_-_29253001 4.676 ENSMUST00000071201.4
 Ntng2
netrin G2
chr18_-_38601268 4.645 ENSMUST00000025295.6
 Spry4
sprouty homolog 4 (Drosophila)
chr6_-_115251839 4.625 ENSMUST00000032462.6
 Timp4
tissue inhibitor of metalloproteinase 4
chr6_+_86195214 4.591 ENSMUST00000032066.9
 Tgfa
transforming growth factor alpha
chrX_+_101299207 4.485 ENSMUST00000065858.2
 Nlgn3
neuroligin 3
chr6_-_125494754 4.264 ENSMUST00000032492.8
 Cd9
CD9 antigen
chr1_-_135167606 4.163 ENSMUST00000027682.8
 Gpr37l1
G protein-coupled receptor 37-like 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 179 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 13.0 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.2 11.5 GO:0048663 neuron fate commitment(GO:0048663)
0.2 10.6 GO:0007528 neuromuscular junction development(GO:0007528)
1.6 9.6 GO:0060024 rhythmic synaptic transmission(GO:0060024)
1.3 7.9 GO:0007021 tubulin complex assembly(GO:0007021)
0.4 7.1 GO:0021516 dorsal spinal cord development(GO:0021516)
0.6 7.0 GO:1902993 positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
1.7 6.8 GO:0060032 notochord regression(GO:0060032)
0.5 6.0 GO:0042711 maternal behavior(GO:0042711)
1.2 5.9 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
1.9 5.7 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241)
0.1 5.7 GO:0008542 visual learning(GO:0008542)
0.2 5.3 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.7 4.9 GO:0032811 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) negative regulation of epinephrine secretion(GO:0032811)
1.6 4.8 GO:1904685 positive regulation of metalloendopeptidase activity(GO:1904685)
0.0 4.8 GO:0006813 potassium ion transport(GO:0006813)
0.9 4.6 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.5 4.6 GO:0071420 cellular response to histamine(GO:0071420)
0.5 4.6 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.6 4.3 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 88 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 14.6 GO:0060077 inhibitory synapse(GO:0060077)
0.1 14.0 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 12.9 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 10.4 GO:0031594 neuromuscular junction(GO:0031594)
0.0 10.4 GO:0005925 focal adhesion(GO:0005925)
0.0 8.6 GO:0005667 transcription factor complex(GO:0005667)
2.4 7.3 GO:0097512 cardiac myofibril(GO:0097512)
0.5 6.8 GO:0097542 ciliary tip(GO:0097542)
0.3 6.5 GO:0032279 asymmetric synapse(GO:0032279)
0.0 6.0 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 5.7 GO:0016323 basolateral plasma membrane(GO:0016323)
1.0 4.9 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.1 4.8 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 4.8 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 4.7 GO:0046658 anchored component of plasma membrane(GO:0046658)
1.4 4.1 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
1.3 4.0 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.1 3.9 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.3 3.7 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.4 3.6 GO:0030478 actin cap(GO:0030478)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 137 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 11.8 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.5 9.5 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 8.3 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.7 6.5 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 6.2 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.8 5.7 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.9 5.6 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.1 5.4 GO:0019210 protein kinase inhibitor activity(GO:0004860) kinase inhibitor activity(GO:0019210)
0.3 5.1 GO:0015026 coreceptor activity(GO:0015026)
0.8 4.9 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.2 4.9 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.5 4.8 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.4 4.6 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.3 4.6 GO:0004890 GABA-A receptor activity(GO:0004890) GABA receptor activity(GO:0016917)
0.1 4.6 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 4.2 GO:0005125 cytokine activity(GO:0005125)
0.6 4.1 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
1.3 4.0 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.3 3.8 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.4 3.7 GO:0032050 clathrin heavy chain binding(GO:0032050)