Motif ID: Glis2

Z-value: 1.015


Transcription factors associated with Glis2:

Gene SymbolEntrez IDGene Name
Glis2 ENSMUSG00000014303.7 Glis2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Glis2mm10_v2_chr16_+_4594683_45947350.028.9e-01Click!


Activity profile for motif Glis2.

activity profile for motif Glis2


Sorted Z-values histogram for motif Glis2

Sorted Z-values for motif Glis2



Network of associatons between targets according to the STRING database.



First level regulatory network of Glis2

PNG image of the network

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Top targets:


Showing 1 to 20 of 183 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_87948666 9.454 ENSMUST00000005019.5
 Crabp2
cellular retinoic acid binding protein II
chr7_-_103843154 6.067 ENSMUST00000063957.4
 Hbb-bh1
hemoglobin Z, beta-like embryonic chain
chr8_+_3631109 4.021 ENSMUST00000004745.8
 Stxbp2
syntaxin binding protein 2
chr19_+_7268296 3.924 ENSMUST00000066646.4
 Rcor2
REST corepressor 2
chr2_-_54085542 3.373 ENSMUST00000100089.2
 Rprm
reprimo, TP53 dependent G2 arrest mediator candidate
chr3_-_89322883 3.090 ENSMUST00000029673.5
 Efna3
ephrin A3
chr5_+_136083916 2.934 ENSMUST00000042135.7
 Rasa4
RAS p21 protein activator 4
chr5_+_136084022 2.840 ENSMUST00000100570.3
 Rasa4
RAS p21 protein activator 4
chr7_-_126704736 2.801 ENSMUST00000131415.1
 Coro1a
coronin, actin binding protein 1A
chr11_+_101468164 2.569 ENSMUST00000001347.6
 Rnd2
Rho family GTPase 2
chr12_+_109544498 2.463 ENSMUST00000126289.1
 Meg3
maternally expressed 3
chr3_-_66981279 2.459 ENSMUST00000162098.2
 Shox2
short stature homeobox 2
chr4_-_58499398 2.408 ENSMUST00000107570.1
 Lpar1
lysophosphatidic acid receptor 1
chr2_+_4976113 2.356 ENSMUST00000167607.1
ENSMUST00000115010.2
 Ucma

upper zone of growth plate and cartilage matrix associated

chr8_-_87472576 2.336 ENSMUST00000034076.8
 Cbln1
cerebellin 1 precursor protein
chr7_-_126704816 2.094 ENSMUST00000032949.7
 Coro1a
coronin, actin binding protein 1A
chr11_-_106160708 1.996 ENSMUST00000106875.1
 Limd2
LIM domain containing 2
chr2_-_57124003 1.985 ENSMUST00000112629.1
 Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr11_+_4873951 1.929 ENSMUST00000038570.2
 Nipsnap1
4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (C. elegans)
chr16_-_45724600 1.916 ENSMUST00000096057.4
 Tagln3
transgelin 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 91 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 12.0 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
1.2 6.1 GO:0015671 oxygen transport(GO:0015671)
0.1 5.8 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.5 5.1 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.8 4.9 GO:0032796 uropod organization(GO:0032796)
0.2 4.0 GO:0033006 regulation of mast cell activation involved in immune response(GO:0033006) regulation of mast cell degranulation(GO:0043304)
0.9 3.7 GO:0051866 general adaptation syndrome(GO:0051866)
0.0 3.4 GO:0007050 cell cycle arrest(GO:0007050)
0.5 3.2 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
0.1 3.1 GO:0008340 determination of adult lifespan(GO:0008340)
0.1 3.1 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.3 2.8 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 2.7 GO:0007498 mesoderm development(GO:0007498)
0.2 2.5 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.6 2.4 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.2 2.3 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.5 2.2 GO:0046898 response to cycloheximide(GO:0046898)
0.2 2.2 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040) negative regulation of protein folding(GO:1903333)
0.0 2.1 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.2 1.9 GO:0015074 DNA integration(GO:0015074)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 6.1 GO:0005833 hemoglobin complex(GO:0005833)
0.4 5.8 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 5.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 4.9 GO:0001891 phagocytic cup(GO:0001891)
0.6 4.5 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 4.1 GO:0017053 transcriptional repressor complex(GO:0017053)
1.3 4.0 GO:0044194 cytolytic granule(GO:0044194)
0.1 3.8 GO:0016235 aggresome(GO:0016235)
0.2 2.8 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 2.6 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 2.4 GO:0043198 dendritic shaft(GO:0043198)
0.3 2.2 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 2.2 GO:0005882 intermediate filament(GO:0005882)
0.0 2.0 GO:0005769 early endosome(GO:0005769)
0.2 1.5 GO:0097452 GAIT complex(GO:0097452)
0.2 1.5 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0 1.5 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.4 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 1.3 GO:0031519 PcG protein complex(GO:0031519)
0.0 1.2 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 9.5 GO:0019841 retinol binding(GO:0019841)
1.5 6.1 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.5 4.9 GO:0032036 myosin heavy chain binding(GO:0032036)
0.6 4.5 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.2 4.0 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 4.0 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 3.5 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 3.3 GO:0005096 GTPase activator activity(GO:0005096)
0.1 3.1 GO:0046875 ephrin receptor binding(GO:0046875)
0.5 2.8 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 2.6 GO:0047485 protein N-terminus binding(GO:0047485)
0.1 2.5 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.4 2.4 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.7 2.2 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.3 2.2 GO:0051434 BH3 domain binding(GO:0051434)
0.2 2.2 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.4 1.9 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 1.9 GO:0042165 neurotransmitter binding(GO:0042165)
0.0 1.9 GO:0005246 calcium channel regulator activity(GO:0005246)
0.1 1.8 GO:0017161 phosphohistidine phosphatase activity(GO:0008969) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) NADP phosphatase activity(GO:0019178) 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity(GO:0043726) phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813) inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity(GO:0052825) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828) inositol-1,3,4-trisphosphate 1-phosphatase activity(GO:0052829) inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity(GO:0052830) inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity(GO:0052831) phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052867) IDP phosphatase activity(GO:1990003)