Motif ID: Glis3

Z-value: 0.615


Transcription factors associated with Glis3:

Gene SymbolEntrez IDGene Name
Glis3 ENSMUSG00000052942.7 Glis3
Glis3 ENSMUSG00000091294.1 Glis3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Glis3mm10_v2_chr19_-_28680077_28680122-0.115.3e-01Click!


Activity profile for motif Glis3.

activity profile for motif Glis3


Sorted Z-values histogram for motif Glis3

Sorted Z-values for motif Glis3



Network of associatons between targets according to the STRING database.



First level regulatory network of Glis3

PNG image of the network

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Top targets:


Showing 1 to 20 of 119 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_134018829 9.057 ENSMUST00000051674.2
 Lin28a
lin-28 homolog A (C. elegans)
chr3_+_107595031 5.593 ENSMUST00000014747.1
 Alx3
aristaless-like homeobox 3
chr8_-_87959560 5.030 ENSMUST00000109655.2
 Zfp423
zinc finger protein 423
chr7_-_49636847 4.963 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr12_+_109743787 4.426 ENSMUST00000183068.1
 Mirg
miRNA containing gene
chr7_-_142899985 4.426 ENSMUST00000000219.3
 Th
tyrosine hydroxylase
chr17_-_70851189 4.134 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr5_-_24527276 3.856 ENSMUST00000088311.4
 Gbx1
gastrulation brain homeobox 1
chr3_-_66981279 3.159 ENSMUST00000162098.2
 Shox2
short stature homeobox 2
chr9_-_48835932 2.944 ENSMUST00000093852.3
 Zbtb16
zinc finger and BTB domain containing 16
chr7_-_142657466 2.732 ENSMUST00000097936.2
ENSMUST00000000033.5
 Igf2

insulin-like growth factor 2

chr13_-_29984219 2.399 ENSMUST00000146092.1
 E2f3
E2F transcription factor 3
chr13_-_40730416 2.276 ENSMUST00000021787.5
 Tfap2a
transcription factor AP-2, alpha
chr11_-_97187872 2.161 ENSMUST00000001479.4
 Kpnb1
karyopherin (importin) beta 1
chr7_+_45017953 2.019 ENSMUST00000044111.7
 Rras
Harvey rat sarcoma oncogene, subgroup R
chr6_+_88198656 1.802 ENSMUST00000015197.7
 Gata2
GATA binding protein 2
chr11_-_102317860 1.774 ENSMUST00000107117.2
 Ubtf
upstream binding transcription factor, RNA polymerase I
chr13_+_44730726 1.750 ENSMUST00000173704.1
ENSMUST00000044608.7
ENSMUST00000173367.1
 Jarid2


jumonji, AT rich interactive domain 2


chr2_+_32646586 1.692 ENSMUST00000009705.7
ENSMUST00000167841.1
 Eng

endoglin

chr16_+_20673517 1.644 ENSMUST00000115460.1
 Eif4g1
eukaryotic translation initiation factor 4, gamma 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 9.1 GO:0010587 miRNA catabolic process(GO:0010587)
0.3 8.8 GO:0035115 embryonic forelimb morphogenesis(GO:0035115)
0.3 5.0 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.1 5.0 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
1.1 4.4 GO:0042414 epinephrine metabolic process(GO:0042414)
0.8 4.2 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.2 4.1 GO:0038092 nodal signaling pathway(GO:0038092)
1.0 3.9 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.6 2.9 GO:0048133 NK T cell differentiation(GO:0001865) germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138) germline stem cell asymmetric division(GO:0098728)
0.3 2.7 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.1 2.6 GO:0051602 response to electrical stimulus(GO:0051602)
0.0 2.5 GO:0002209 behavioral fear response(GO:0001662) behavioral defense response(GO:0002209)
0.8 2.3 GO:0070172 oculomotor nerve development(GO:0021557) positive regulation of tooth mineralization(GO:0070172)
0.5 2.2 GO:0051305 chromosome movement towards spindle pole(GO:0051305)
0.0 1.9 GO:0060325 face morphogenesis(GO:0060325)
0.2 1.8 GO:0006362 transcription elongation from RNA polymerase I promoter(GO:0006362)
0.1 1.8 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.6 1.7 GO:0003032 detection of oxygen(GO:0003032)
0.4 1.7 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.2 1.7 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.1 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 8.9 GO:0005667 transcription factor complex(GO:0005667)
0.2 4.4 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 4.4 GO:0016605 PML body(GO:0016605)
0.3 3.1 GO:0016589 NURF complex(GO:0016589)
0.3 2.5 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.2 2.2 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 2.1 GO:0072562 blood microparticle(GO:0072562)
0.1 1.8 GO:0001650 fibrillar center(GO:0001650)
0.1 1.8 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 1.7 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.2 1.6 GO:0042382 paraspeckles(GO:0042382)
0.0 1.5 GO:0031519 PcG protein complex(GO:0031519)
0.0 1.5 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 1.5 GO:0016607 nuclear speck(GO:0016607)
0.1 1.4 GO:0097539 ciliary transition fiber(GO:0097539)
0.1 1.4 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 1.3 GO:0032993 protein-DNA complex(GO:0032993)
0.2 1.1 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.1 1.0 GO:0005642 annulate lamellae(GO:0005642)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 19.5 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.5 9.1 GO:0035198 miRNA binding(GO:0035198)
0.0 5.6 GO:0001047 core promoter binding(GO:0001047)
0.7 4.4 GO:0035240 dopamine binding(GO:0035240)
0.2 4.1 GO:0070410 co-SMAD binding(GO:0070410)
0.3 2.9 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.1 2.7 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.2 2.5 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.1 2.4 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 2.2 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 2.1 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.4 1.8 GO:0001165 RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165)
0.3 1.8 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.1 1.8 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.6 1.7 GO:0005534 galactose binding(GO:0005534)
0.1 1.7 GO:0001786 phosphatidylserine binding(GO:0001786)
0.4 1.5 GO:0050700 CARD domain binding(GO:0050700)
0.1 1.5 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 1.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 1.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)