Motif ID: Gsx2_Hoxd3_Vax1

Z-value: 0.721

Transcription factors associated with Gsx2_Hoxd3_Vax1:

Gene SymbolEntrez IDGene Name
Gsx2 ENSMUSG00000035946.6 Gsx2
Hoxd3 ENSMUSG00000079277.3 Hoxd3
Vax1 ENSMUSG00000006270.6 Vax1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gsx2mm10_v2_chr5_+_75075464_750756010.411.7e-02Click!
Vax1mm10_v2_chr19_-_59170978_591709780.354.6e-02Click!


Activity profile for motif Gsx2_Hoxd3_Vax1.

activity profile for motif Gsx2_Hoxd3_Vax1


Sorted Z-values histogram for motif Gsx2_Hoxd3_Vax1

Sorted Z-values for motif Gsx2_Hoxd3_Vax1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gsx2_Hoxd3_Vax1

PNG image of the network

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Top targets:


Showing 1 to 20 of 159 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_48662740 6.388 ENSMUST00000122009.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr2_+_109917639 6.206 ENSMUST00000046548.7
ENSMUST00000111037.2
 Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr2_-_168767136 5.836 ENSMUST00000029061.5
ENSMUST00000103074.1
 Sall4

sal-like 4 (Drosophila)

chr9_+_119063429 4.902 ENSMUST00000141185.1
ENSMUST00000126251.1
ENSMUST00000136561.1
 Vill


villin-like


chr2_-_168767029 4.284 ENSMUST00000075044.3
 Sall4
sal-like 4 (Drosophila)
chr15_+_25773985 3.568 ENSMUST00000125667.1
 Myo10
myosin X
chr9_-_90255927 3.292 ENSMUST00000144646.1
 Tbc1d2b
TBC1 domain family, member 2B
chr13_-_53473074 3.249 ENSMUST00000021922.8
 Msx2
msh homeobox 2
chr18_+_56432116 2.433 ENSMUST00000070166.5
 Gramd3
GRAM domain containing 3
chr19_+_55895508 2.407 ENSMUST00000111646.1
 Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chrX_+_150547375 2.291 ENSMUST00000066337.6
ENSMUST00000112715.1
 Alas2

aminolevulinic acid synthase 2, erythroid

chr4_+_8690399 2.271 ENSMUST00000127476.1
 Chd7
chromodomain helicase DNA binding protein 7
chr6_-_23248264 2.142 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr3_+_159839729 2.082 ENSMUST00000068952.5
 Wls
wntless homolog (Drosophila)
chr6_-_34317442 1.819 ENSMUST00000154655.1
ENSMUST00000102980.4
 Akr1b3

aldo-keto reductase family 1, member B3 (aldose reductase)

chr10_+_128337761 1.819 ENSMUST00000005826.7
 Cs
citrate synthase
chr13_+_51408618 1.785 ENSMUST00000087978.3
 S1pr3
sphingosine-1-phosphate receptor 3
chr2_+_120476911 1.761 ENSMUST00000110716.1
ENSMUST00000028748.6
ENSMUST00000090028.5
ENSMUST00000110719.2
 Capn3



calpain 3



chr11_+_59306920 1.627 ENSMUST00000000128.3
ENSMUST00000108783.3
 Wnt9a

wingless-type MMTV integration site 9A

chr17_-_70853482 1.615 ENSMUST00000118283.1
 Tgif1
TGFB-induced factor homeobox 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 71 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 10.4 GO:0001833 inner cell mass cell proliferation(GO:0001833)
1.6 6.4 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
2.1 6.2 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.1 4.7 GO:0051693 actin filament capping(GO:0051693)
1.3 4.0 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.1 3.6 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.0 3.3 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.3 2.4 GO:0048625 myoblast fate commitment(GO:0048625)
0.8 2.3 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.6 2.3 GO:0010700 negative regulation of norepinephrine secretion(GO:0010700)
0.1 2.3 GO:0042541 hemoglobin biosynthetic process(GO:0042541)
0.1 2.3 GO:0030901 midbrain development(GO:0030901)
0.4 2.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.2 2.1 GO:0031017 exocrine pancreas development(GO:0031017)
0.0 1.9 GO:0007601 visual perception(GO:0007601)
0.6 1.8 GO:0006059 hexitol metabolic process(GO:0006059) alditol biosynthetic process(GO:0019401)
0.6 1.8 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
0.2 1.8 GO:0045602 negative regulation of endothelial cell differentiation(GO:0045602)
0.1 1.8 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.1 1.6 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.7 GO:0000792 heterochromatin(GO:0000792)
0.0 6.4 GO:0030426 growth cone(GO:0030426)
0.0 4.6 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 3.6 GO:0016459 myosin complex(GO:0016459)
0.3 2.4 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 2.4 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 2.1 GO:0032839 dendrite cytoplasm(GO:0032839)
0.5 1.8 GO:0097454 Schwann cell microvillus(GO:0097454)
0.3 1.3 GO:0008623 CHRAC(GO:0008623)
0.1 1.3 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 1.3 GO:0001750 photoreceptor outer segment(GO:0001750)
0.2 1.2 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0 1.2 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 1.2 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 1.2 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 1.1 GO:0016600 flotillin complex(GO:0016600)
0.0 1.1 GO:0009925 basal plasma membrane(GO:0009925)
0.1 0.9 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 0.9 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.8 GO:0016327 apicolateral plasma membrane(GO:0016327)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 11.7 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 10.1 GO:0044212 transcription regulatory region DNA binding(GO:0044212)
0.5 6.2 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 5.5 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1 3.6 GO:0030507 spectrin binding(GO:0030507)
0.0 2.9 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 2.4 GO:0045295 gamma-catenin binding(GO:0045295)
0.1 2.3 GO:0016594 glycine binding(GO:0016594)
0.1 2.3 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.2 2.1 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.6 1.9 GO:0005118 sevenless binding(GO:0005118)
0.3 1.8 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.2 1.8 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.2 1.8 GO:0031432 titin binding(GO:0031432)
0.1 1.8 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.1 1.6 GO:0070410 co-SMAD binding(GO:0070410)
0.0 1.6 GO:0005109 frizzled binding(GO:0005109)
0.0 1.5 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 1.4 GO:0004812 aminoacyl-tRNA ligase activity(GO:0004812)
0.0 1.3 GO:0004601 peroxidase activity(GO:0004601)