Motif ID: Gtf2i_Gtf2f1

Z-value: 2.954

Transcription factors associated with Gtf2i_Gtf2f1:

Gene SymbolEntrez IDGene Name
Gtf2f1 ENSMUSG00000002658.9 Gtf2f1
Gtf2i ENSMUSG00000060261.9 Gtf2i

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gtf2imm10_v2_chr5_-_134314637_1343146760.364.1e-02Click!
Gtf2f1mm10_v2_chr17_-_57011271_57011326-0.115.4e-01Click!


Activity profile for motif Gtf2i_Gtf2f1.

activity profile for motif Gtf2i_Gtf2f1


Sorted Z-values histogram for motif Gtf2i_Gtf2f1

Sorted Z-values for motif Gtf2i_Gtf2f1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gtf2i_Gtf2f1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66948419 37.918 ENSMUST00000167817.1
 Ndrg1
N-myc downstream regulated gene 1
chr14_-_55116935 23.738 ENSMUST00000022819.5
 Jph4
junctophilin 4
chr7_+_44310213 23.217 ENSMUST00000107938.1
 Shank1
SH3/ankyrin domain gene 1
chr1_-_56971762 18.828 ENSMUST00000114415.3
 Satb2
special AT-rich sequence binding protein 2
chr6_-_32588192 17.638 ENSMUST00000115096.2
 Plxna4
plexin A4
chr16_-_74411292 17.424 ENSMUST00000117200.1
 Robo2
roundabout homolog 2 (Drosophila)
chr7_-_126949499 16.753 ENSMUST00000106339.1
ENSMUST00000052937.5
 Asphd1

aspartate beta-hydroxylase domain containing 1

chr11_-_118909487 16.570 ENSMUST00000117731.1
ENSMUST00000106278.2
ENSMUST00000120061.1
ENSMUST00000017576.4
 Rbfox3



RNA binding protein, fox-1 homolog (C. elegans) 3



chr9_+_40686002 15.094 ENSMUST00000034522.7
 Clmp
CXADR-like membrane protein
chr16_-_74411776 15.057 ENSMUST00000116586.2
 Robo2
roundabout homolog 2 (Drosophila)
chr2_+_136713444 14.932 ENSMUST00000028727.4
ENSMUST00000110098.3
 Snap25

synaptosomal-associated protein 25

chr4_-_82505749 14.840 ENSMUST00000107245.2
ENSMUST00000107246.1
 Nfib

nuclear factor I/B

chr6_-_77979652 14.581 ENSMUST00000161846.1
ENSMUST00000160894.1
 Ctnna2

catenin (cadherin associated protein), alpha 2

chr15_-_76521902 14.433 ENSMUST00000164703.1
ENSMUST00000096365.3
 Scrt1

scratch homolog 1, zinc finger protein (Drosophila)

chr6_-_77979515 14.110 ENSMUST00000159626.1
ENSMUST00000075340.5
ENSMUST00000162273.1
 Ctnna2


catenin (cadherin associated protein), alpha 2


chrX_-_104201126 14.000 ENSMUST00000056502.6
ENSMUST00000118314.1
 C77370

expressed sequence C77370

chr1_+_178798438 13.944 ENSMUST00000160789.1
 Kif26b
kinesin family member 26B
chr8_+_112570043 13.909 ENSMUST00000034225.6
ENSMUST00000118171.1
 Cntnap4

contactin associated protein-like 4

chr5_-_120711927 13.658 ENSMUST00000031607.6
 Dtx1
deltex 1 homolog (Drosophila)
chr12_-_27342696 13.586 ENSMUST00000079063.5
 Sox11
SRY-box containing gene 11

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 571 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.4 53.6 GO:2000821 regulation of grooming behavior(GO:2000821)
2.6 41.5 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
13.1 39.2 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
3.2 38.1 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
3.8 37.9 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
5.7 34.0 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.4 34.0 GO:0007612 learning(GO:0007612)
7.6 30.5 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.5 29.4 GO:0051965 positive regulation of synapse assembly(GO:0051965)
3.6 25.2 GO:0032811 negative regulation of epinephrine secretion(GO:0032811)
2.5 25.1 GO:0010807 regulation of synaptic vesicle priming(GO:0010807)
0.9 24.5 GO:2001222 regulation of neuron migration(GO:2001222)
0.4 24.2 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
1.9 22.9 GO:0016082 synaptic vesicle priming(GO:0016082)
7.5 22.5 GO:0046959 habituation(GO:0046959)
1.4 22.1 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
0.4 21.7 GO:0046513 ceramide biosynthetic process(GO:0046513)
1.0 21.3 GO:0060074 synapse maturation(GO:0060074)
0.3 20.8 GO:0006836 neurotransmitter transport(GO:0006836)
4.9 19.8 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 215 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 108.2 GO:0060076 excitatory synapse(GO:0060076)
3.5 74.0 GO:0044300 cerebellar mossy fiber(GO:0044300)
1.2 68.2 GO:0042734 presynaptic membrane(GO:0042734)
0.4 51.8 GO:0070382 exocytic vesicle(GO:0070382)
1.6 46.1 GO:0030673 axolemma(GO:0030673)
0.1 44.2 GO:0045202 synapse(GO:0045202)
1.2 39.4 GO:0055038 recycling endosome membrane(GO:0055038)
7.1 35.6 GO:0030314 junctional membrane complex(GO:0030314)
1.9 32.5 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
1.2 32.4 GO:0060077 inhibitory synapse(GO:0060077)
1.0 31.2 GO:0098878 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.4 30.4 GO:0043204 perikaryon(GO:0043204)
0.3 28.9 GO:0000118 histone deacetylase complex(GO:0000118)
4.7 23.5 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.7 22.5 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
1.9 22.3 GO:0032279 asymmetric synapse(GO:0032279)
5.4 21.7 GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
1.8 18.0 GO:0032591 dendritic spine membrane(GO:0032591)
0.5 16.5 GO:0035371 microtubule plus-end(GO:0035371)
1.5 16.1 GO:0002116 semaphorin receptor complex(GO:0002116)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 346 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 70.3 GO:0045296 cadherin binding(GO:0045296)
0.2 65.8 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.4 55.9 GO:0017124 SH3 domain binding(GO:0017124)
4.4 39.2 GO:0008046 axon guidance receptor activity(GO:0008046)
1.6 37.5 GO:0017075 syntaxin-1 binding(GO:0017075)
0.9 30.9 GO:0070412 R-SMAD binding(GO:0070412)
5.0 29.8 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.2 28.2 GO:0003714 transcription corepressor activity(GO:0003714)
3.5 28.1 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
1.6 28.0 GO:0050321 tau-protein kinase activity(GO:0050321)
3.9 27.4 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
1.8 24.7 GO:0017154 semaphorin receptor activity(GO:0017154)
6.1 24.3 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.5 23.7 GO:0045499 chemorepellent activity(GO:0045499)
3.9 23.5 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
1.6 22.2 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.6 21.3 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
2.4 21.2 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
2.5 20.1 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.6 19.9 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)