Motif ID: Hand1

Z-value: 1.062


Transcription factors associated with Hand1:

Gene SymbolEntrez IDGene Name
Hand1 ENSMUSG00000037335.7 Hand1



Activity profile for motif Hand1.

activity profile for motif Hand1


Sorted Z-values histogram for motif Hand1

Sorted Z-values for motif Hand1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hand1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_+_81936911 8.382 ENSMUST00000135663.1
 Csdc2
cold shock domain containing C2, RNA binding
chr7_-_30445508 7.024 ENSMUST00000006828.7
 Aplp1
amyloid beta (A4) precursor-like protein 1
chr15_+_92051153 6.822 ENSMUST00000169825.1
 Cntn1
contactin 1
chr8_+_84723003 5.206 ENSMUST00000098571.4
 G430095P16Rik
RIKEN cDNA G430095P16 gene
chr19_-_59076069 4.951 ENSMUST00000047511.7
ENSMUST00000163821.1
 4930506M07Rik

RIKEN cDNA 4930506M07 gene

chr14_-_73385225 4.940 ENSMUST00000022704.7
 Itm2b
integral membrane protein 2B
chr16_-_36784924 4.921 ENSMUST00000168279.1
ENSMUST00000164579.1
ENSMUST00000023616.2
 Slc15a2


solute carrier family 15 (H+/peptide transporter), member 2


chr15_+_81936753 4.874 ENSMUST00000038757.7
 Csdc2
cold shock domain containing C2, RNA binding
chr4_-_20778527 4.537 ENSMUST00000119374.1
 Nkain3
Na+/K+ transporting ATPase interacting 3
chr1_-_135167606 4.358 ENSMUST00000027682.8
 Gpr37l1
G protein-coupled receptor 37-like 1
chr14_-_62456286 4.056 ENSMUST00000165651.1
ENSMUST00000022501.3
 Gucy1b2

guanylate cyclase 1, soluble, beta 2

chr5_+_19907502 3.956 ENSMUST00000101558.3
 Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr1_-_176807124 3.903 ENSMUST00000057037.7
 Cep170
centrosomal protein 170
chr1_+_75507077 3.762 ENSMUST00000037330.4
 Inha
inhibin alpha
chr11_-_95041335 3.460 ENSMUST00000038431.7
 Pdk2
pyruvate dehydrogenase kinase, isoenzyme 2
chr5_-_84417359 3.451 ENSMUST00000113401.1
 Epha5
Eph receptor A5
chr2_-_168741752 3.437 ENSMUST00000029060.4
 Atp9a
ATPase, class II, type 9A
chr8_-_109251698 3.365 ENSMUST00000079189.3
 4922502B01Rik
RIKEN cDNA 4922502B01 gene
chr15_-_81697256 3.339 ENSMUST00000072910.5
 Chadl
chondroadherin-like
chr5_+_81021202 3.277 ENSMUST00000117253.1
ENSMUST00000120128.1
 Lphn3

latrophilin 3


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 142 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 13.3 GO:0002028 regulation of sodium ion transport(GO:0002028)
0.0 10.6 GO:0006397 mRNA processing(GO:0006397)
0.3 7.9 GO:0060074 synapse maturation(GO:0060074)
2.3 7.0 GO:0071873 response to norepinephrine(GO:0071873)
0.8 6.7 GO:2000809 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118) positive regulation of synaptic vesicle clustering(GO:2000809)
0.3 6.1 GO:0048712 negative regulation of astrocyte differentiation(GO:0048712)
0.3 5.4 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.2 5.4 GO:0045838 positive regulation of membrane potential(GO:0045838)
0.9 5.3 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.7 5.2 GO:2001023 regulation of response to drug(GO:2001023)
1.2 4.9 GO:0042938 dipeptide transport(GO:0042938)
0.2 4.7 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.2 4.7 GO:0097320 membrane tubulation(GO:0097320)
0.3 4.6 GO:0090161 Golgi ribbon formation(GO:0090161)
1.1 4.5 GO:0035063 nuclear speck organization(GO:0035063)
1.4 4.2 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.5 4.2 GO:0097369 sodium ion import(GO:0097369)
0.0 4.1 GO:0006906 vesicle fusion(GO:0006906)
0.4 4.0 GO:0090385 phagosome-lysosome fusion(GO:0090385)
1.0 3.9 GO:0014043 negative regulation of neuron maturation(GO:0014043)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 77 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.6 GO:0031225 anchored component of membrane(GO:0031225)
1.2 7.2 GO:0044308 axonal spine(GO:0044308)
1.3 6.7 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.3 5.9 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1 5.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 5.1 GO:0005769 early endosome(GO:0005769)
0.1 4.9 GO:0030660 Golgi-associated vesicle membrane(GO:0030660)
0.5 4.7 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.4 4.7 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 4.7 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 4.7 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.3 4.6 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.1 4.4 GO:0043198 dendritic shaft(GO:0043198)
0.0 4.4 GO:0043235 receptor complex(GO:0043235)
0.0 3.9 GO:0005814 centriole(GO:0005814)
1.3 3.8 GO:0043512 inhibin-betaglycan-ActRII complex(GO:0034673) inhibin A complex(GO:0043512)
0.1 3.6 GO:0031985 Golgi cisterna(GO:0031985)
1.2 3.5 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.0 3.5 GO:0016607 nuclear speck(GO:0016607)
0.6 3.3 GO:1990635 proximal dendrite(GO:1990635)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 101 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.2 GO:0017124 SH3 domain binding(GO:0017124)
1.8 7.0 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
1.1 6.7 GO:0070699 type II activin receptor binding(GO:0070699)
0.3 5.9 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 5.6 GO:0001948 glycoprotein binding(GO:0001948)
0.8 5.4 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 5.3 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 5.3 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
1.0 4.9 GO:0042895 antibiotic transporter activity(GO:0042895)
0.1 4.9 GO:0030276 clathrin binding(GO:0030276)
0.5 4.7 GO:0004383 guanylate cyclase activity(GO:0004383)
0.1 4.7 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.7 4.2 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.2 4.0 GO:0017160 Ral GTPase binding(GO:0017160)
0.5 3.8 GO:0034711 inhibin binding(GO:0034711)
0.9 3.5 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.4 3.5 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.2 3.4 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.2 3.3 GO:0005540 hyaluronic acid binding(GO:0005540)
1.1 3.2 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)