Motif ID: Hcfc1_Six5_Smarcc2_Zfp143

Z-value: 3.550

Transcription factors associated with Hcfc1_Six5_Smarcc2_Zfp143:

Gene SymbolEntrez IDGene Name
Hcfc1 ENSMUSG00000031386.8 Hcfc1
Six5 ENSMUSG00000040841.5 Six5
Smarcc2 ENSMUSG00000025369.8 Smarcc2
Zfp143 ENSMUSG00000061079.7 Zfp143

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smarcc2mm10_v2_chr10_+_128459236_1284592480.373.4e-02Click!
Six5mm10_v2_chr7_+_19094594_19094633-0.086.4e-01Click!
Hcfc1mm10_v2_chrX_-_73966329_739663760.029.2e-01Click!
Zfp143mm10_v2_chr7_+_110061702_110061732-0.019.7e-01Click!


Activity profile for motif Hcfc1_Six5_Smarcc2_Zfp143.

activity profile for motif Hcfc1_Six5_Smarcc2_Zfp143


Sorted Z-values histogram for motif Hcfc1_Six5_Smarcc2_Zfp143

Sorted Z-values for motif Hcfc1_Six5_Smarcc2_Zfp143



Network of associatons between targets according to the STRING database.



First level regulatory network of Hcfc1_Six5_Smarcc2_Zfp143

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_44384803 7.066 ENSMUST00000120262.1
 Syt3
synaptotagmin III
chr4_-_116708312 6.494 ENSMUST00000030453.4
 Mmachc
methylmalonic aciduria cblC type, with homocystinuria
chr7_+_44384604 6.300 ENSMUST00000130707.1
ENSMUST00000130844.1
 Syt3

synaptotagmin III

chr7_+_6172482 6.258 ENSMUST00000108567.1
ENSMUST00000054680.5
ENSMUST00000108566.1
 Zfp444


zinc finger protein 444


chr7_+_19119853 6.176 ENSMUST00000053109.3
 Fbxo46
F-box protein 46
chr5_-_149636331 5.860 ENSMUST00000074846.7
ENSMUST00000110498.1
ENSMUST00000127977.1
ENSMUST00000132412.1
 Hsph1



heat shock 105kDa/110kDa protein 1



chr8_+_71464910 5.786 ENSMUST00000048914.6
 Mrpl34
mitochondrial ribosomal protein L34
chr5_-_135934590 5.661 ENSMUST00000055808.5
 Ywhag
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
chr4_+_83417715 5.587 ENSMUST00000030206.3
ENSMUST00000071544.4
 Snapc3

small nuclear RNA activating complex, polypeptide 3

chr13_-_110280103 5.578 ENSMUST00000167824.1
 Rab3c
RAB3C, member RAS oncogene family
chr7_+_44468020 5.387 ENSMUST00000117324.1
ENSMUST00000120852.1
ENSMUST00000118628.1
 Josd2


Josephin domain containing 2


chr8_+_121950492 5.374 ENSMUST00000093078.6
ENSMUST00000170857.1
ENSMUST00000026354.8
ENSMUST00000174753.1
ENSMUST00000172511.1
 Banp




BTG3 associated nuclear protein




chr8_-_106337987 5.366 ENSMUST00000067512.7
 Smpd3
sphingomyelin phosphodiesterase 3, neutral
chr1_+_151428612 5.344 ENSMUST00000065625.5
 Trmt1l
tRNA methyltransferase 1 like
chr15_-_43869993 5.174 ENSMUST00000067469.4
 Tmem74
transmembrane protein 74
chr17_-_23673825 5.110 ENSMUST00000115490.1
ENSMUST00000047436.4
ENSMUST00000138190.1
ENSMUST00000095579.4
 Thoc6



THO complex 6 homolog (Drosophila)



chr1_+_172482199 5.105 ENSMUST00000135267.1
ENSMUST00000052629.6
ENSMUST00000111235.2
 Igsf9


immunoglobulin superfamily, member 9


chr4_+_116708687 5.094 ENSMUST00000135499.1
 Ccdc163
coiled-coil domain containing 163
chr7_+_44384098 5.054 ENSMUST00000118962.1
ENSMUST00000118831.1
 Syt3

synaptotagmin III

chr17_+_25985815 5.018 ENSMUST00000180932.1
 1700022N22Rik
RIKEN cDNA 1700022N22 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 377 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 31.5 GO:1903506 regulation of nucleic acid-templated transcription(GO:1903506)
0.0 19.5 GO:0006412 translation(GO:0006412)
1.0 18.4 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.1 15.5 GO:0016579 protein deubiquitination(GO:0016579)
0.1 10.5 GO:0098792 xenophagy(GO:0098792)
0.9 9.9 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
0.1 9.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.5 7.6 GO:0033327 Leydig cell differentiation(GO:0033327)
0.1 7.6 GO:0030518 intracellular steroid hormone receptor signaling pathway(GO:0030518)
2.5 7.4 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
0.2 6.9 GO:0006378 mRNA polyadenylation(GO:0006378)
1.1 6.8 GO:0009235 cobalamin metabolic process(GO:0009235)
0.3 6.7 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 6.7 GO:0008380 RNA splicing(GO:0008380)
0.1 6.5 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 6.4 GO:1902600 hydrogen ion transmembrane transport(GO:1902600)
0.1 6.1 GO:0008344 adult locomotory behavior(GO:0008344)
1.5 5.9 GO:0045343 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343) positive regulation of MHC class I biosynthetic process(GO:0045345)
1.0 5.9 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.4 5.9 GO:0006107 oxaloacetate metabolic process(GO:0006107)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 199 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 108.3 GO:0005634 nucleus(GO:0005634)
0.1 25.1 GO:0070382 exocytic vesicle(GO:0070382)
0.1 16.4 GO:0005874 microtubule(GO:0005874)
0.4 13.7 GO:0060077 inhibitory synapse(GO:0060077)
0.1 12.3 GO:0005840 ribosome(GO:0005840)
0.4 10.3 GO:0071565 nBAF complex(GO:0071565)
1.1 9.9 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.4 9.9 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 8.5 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.2 8.4 GO:0016592 mediator complex(GO:0016592)
0.2 7.9 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 7.2 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 7.2 GO:0045211 postsynaptic membrane(GO:0045211)
0.2 7.0 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 6.9 GO:0032587 ruffle membrane(GO:0032587)
0.3 6.3 GO:0070822 Sin3-type complex(GO:0070822)
0.1 6.3 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 5.8 GO:0000776 kinetochore(GO:0000776)
0.8 5.7 GO:0001940 male pronucleus(GO:0001940)
0.1 5.3 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 259 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 41.5 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.1 30.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 29.0 GO:0003723 RNA binding(GO:0003723)
0.0 21.1 GO:0008270 zinc ion binding(GO:0008270)
0.6 18.4 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 13.8 GO:0003774 motor activity(GO:0003774)
0.6 12.0 GO:0008242 omega peptidase activity(GO:0008242)
0.1 10.3 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
1.2 9.8 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.2 9.4 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.4 9.2 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1 8.3 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.4 8.2 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.1 8.2 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.1 7.7 GO:0019208 phosphatase regulator activity(GO:0019208)
0.3 7.3 GO:0004708 MAP kinase kinase activity(GO:0004708)
1.0 6.8 GO:0031419 cobalamin binding(GO:0031419)
0.6 6.7 GO:1990226 histone methyltransferase binding(GO:1990226)
0.1 6.4 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds(GO:0016810)
0.1 6.2 GO:0002039 p53 binding(GO:0002039)