Motif ID: Hdx

Z-value: 6.749


Transcription factors associated with Hdx:

Gene SymbolEntrez IDGene Name
Hdx ENSMUSG00000034551.6 Hdx

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hdxmm10_v2_chrX_-_111697069_111697127-0.153.9e-01Click!


Activity profile for motif Hdx.

activity profile for motif Hdx


Sorted Z-values histogram for motif Hdx

Sorted Z-values for motif Hdx



Network of associatons between targets according to the STRING database.



First level regulatory network of Hdx

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_3017408 244.676 ENSMUST00000099049.3
Gm10719
predicted gene 10719
chr9_+_3015654 209.610 ENSMUST00000099050.3
Gm10720
predicted gene 10720
chr9_+_3023547 204.814 ENSMUST00000099046.3
Gm10718
predicted gene 10718
chr9_+_3005125 188.572 ENSMUST00000179881.1
Gm11168
predicted gene 11168
chr9_+_3000922 173.403 ENSMUST00000151376.2
Gm10722
predicted gene 10722
chr9_+_3034599 172.326 ENSMUST00000178641.1
Gm17535
predicted gene, 17535
chr9_+_3027439 167.305 ENSMUST00000177875.1
ENSMUST00000179982.1
Gm10717

predicted gene 10717

chr9_+_3025417 150.278 ENSMUST00000075573.6
Gm10717
predicted gene 10717
chr14_-_19418930 141.343 ENSMUST00000177817.1
Gm21738
predicted gene, 21738
chr9_+_3018753 126.907 ENSMUST00000179272.1
Gm10719
predicted gene 10719
chr9_+_3004457 117.049 ENSMUST00000178348.1
Gm11168
predicted gene 11168
chr9_+_3036877 109.633 ENSMUST00000155807.2
Gm10715
predicted gene 10715
chr9_+_3037111 101.370 ENSMUST00000177969.1
Gm10715
predicted gene 10715
chr9_+_3013140 96.290 ENSMUST00000143083.2
Gm10721
predicted gene 10721
chr2_-_98667264 71.621 ENSMUST00000099683.1
Gm10800
predicted gene 10800
chr6_-_23248264 58.264 ENSMUST00000031709.5
Fezf1
Fez family zinc finger 1
chr3_-_154330543 20.834 ENSMUST00000184966.1
ENSMUST00000177846.2
Lhx8

LIM homeobox protein 8

chr16_-_26989974 18.714 ENSMUST00000089832.4
Gmnc
geminin coiled-coil domain containing
chr13_+_24327415 13.043 ENSMUST00000167746.1
Cmah
cytidine monophospho-N-acetylneuraminic acid hydroxylase
chr2_-_72986716 11.997 ENSMUST00000112062.1
Gm11084
predicted gene 11084
chrX_-_143827391 11.174 ENSMUST00000087316.5
Capn6
calpain 6
chr6_+_30568367 8.695 ENSMUST00000049251.5
Cpa4
carboxypeptidase A4
chr7_+_46847128 8.350 ENSMUST00000005051.4
Ldha
lactate dehydrogenase A
chr17_+_17402672 6.491 ENSMUST00000115576.2
Lix1
limb expression 1 homolog (chicken)
chr4_-_43031429 6.326 ENSMUST00000136326.1
Stoml2
stomatin (Epb7.2)-like 2
chr4_-_133753611 5.820 ENSMUST00000145664.2
ENSMUST00000105897.3
Arid1a

AT rich interactive domain 1A (SWI-like)

chr4_+_89137122 5.196 ENSMUST00000058030.7
Mtap
methylthioadenosine phosphorylase
chr13_+_43370710 5.169 ENSMUST00000066804.4
Sirt5
sirtuin 5
chr4_-_43031370 5.157 ENSMUST00000138030.1
Stoml2
stomatin (Epb7.2)-like 2
chr5_-_27501362 4.953 ENSMUST00000155721.1
ENSMUST00000053257.3
Speer4b

spermatogenesis associated glutamate (E)-rich protein 4b

chr6_+_54267131 4.942 ENSMUST00000114402.2
Chn2
chimerin (chimaerin) 2
chr15_+_10177623 4.748 ENSMUST00000124470.1
Prlr
prolactin receptor
chr2_-_165368723 4.369 ENSMUST00000141140.1
ENSMUST00000103085.1
Zfp663

zinc finger protein 663

chr9_+_45055166 4.190 ENSMUST00000114664.1
ENSMUST00000093856.3
Mpzl3

myelin protein zero-like 3

chr12_-_27160311 4.156 ENSMUST00000182473.1
ENSMUST00000177636.1
ENSMUST00000183238.1
Gm9866


predicted gene 9866


chr7_-_89980935 4.148 ENSMUST00000107234.1
Eed
embryonic ectoderm development
chr11_+_98446826 3.956 ENSMUST00000019456.4
Grb7
growth factor receptor bound protein 7
chr14_+_70774304 3.956 ENSMUST00000022698.7
Dok2
docking protein 2
chr14_+_73138755 3.752 ENSMUST00000171070.1
Rcbtb2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr7_+_13398115 3.715 ENSMUST00000005791.7
Cabp5
calcium binding protein 5
chr16_+_37539883 3.578 ENSMUST00000023524.6
Rabl3
RAB, member of RAS oncogene family-like 3
chr12_-_23780265 3.459 ENSMUST00000072014.4
Gm10330
predicted gene 10330
chr2_+_174415804 3.438 ENSMUST00000109075.1
ENSMUST00000016397.6
Nelfcd

negative elongation factor complex member C/D, Th1l

chr10_+_7667503 3.132 ENSMUST00000040135.8
Nup43
nucleoporin 43
chr11_-_45955465 3.011 ENSMUST00000011398.6
Thg1l
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
chr3_+_95929325 2.953 ENSMUST00000171368.1
ENSMUST00000168106.1
Anp32e

acidic (leucine-rich) nuclear phosphoprotein 32 family, member E

chr14_+_24490678 2.949 ENSMUST00000169826.1
ENSMUST00000112384.3
Rps24

ribosomal protein S24

chr2_-_129371131 2.794 ENSMUST00000028881.7
Il1b
interleukin 1 beta
chr4_-_129640959 2.682 ENSMUST00000132217.1
ENSMUST00000130017.1
ENSMUST00000154105.1
Txlna


taxilin alpha


chrX_+_169879596 2.666 ENSMUST00000112105.1
ENSMUST00000078947.5
Mid1

midline 1

chr4_-_129640691 2.562 ENSMUST00000084264.5
Txlna
taxilin alpha
chr8_-_85025268 2.497 ENSMUST00000064314.8
Asna1
arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)
chr5_+_30013141 2.468 ENSMUST00000026845.7
Il6
interleukin 6
chrX_+_143518671 2.466 ENSMUST00000134402.1
Pak3
p21 protein (Cdc42/Rac)-activated kinase 3
chr4_-_97584605 2.457 ENSMUST00000107067.1
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr14_-_19977040 2.320 ENSMUST00000159028.1
Gng2
guanine nucleotide binding protein (G protein), gamma 2
chrX_+_143518576 2.315 ENSMUST00000033640.7
Pak3
p21 protein (Cdc42/Rac)-activated kinase 3
chr4_-_97584612 2.305 ENSMUST00000107068.2
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr14_+_62292475 2.173 ENSMUST00000166879.1
Rnaseh2b
ribonuclease H2, subunit B
chr13_-_63431683 2.081 ENSMUST00000160931.1
ENSMUST00000099444.3
ENSMUST00000161977.1
ENSMUST00000163091.1
Fancc



Fanconi anemia, complementation group C



chr15_-_80083374 2.071 ENSMUST00000081650.7
Rpl3
ribosomal protein L3
chr14_-_19977151 1.935 ENSMUST00000055100.7
ENSMUST00000162425.1
Gng2

guanine nucleotide binding protein (G protein), gamma 2

chr1_+_87327044 1.887 ENSMUST00000173173.1
Gigyf2
GRB10 interacting GYF protein 2
chr7_-_19359477 1.883 ENSMUST00000047036.8
Cd3eap
CD3E antigen, epsilon polypeptide associated protein
chr2_-_126618655 1.824 ENSMUST00000028838.4
Hdc
histidine decarboxylase
chr4_+_124880899 1.753 ENSMUST00000059343.6
Epha10
Eph receptor A10
chrX_+_56779699 1.752 ENSMUST00000114772.2
ENSMUST00000114768.3
ENSMUST00000155882.1
Fhl1


four and a half LIM domains 1


chr17_+_35059035 1.751 ENSMUST00000007255.6
ENSMUST00000174493.1
Ddah2

dimethylarginine dimethylaminohydrolase 2

chr2_+_105682463 1.737 ENSMUST00000140173.1
ENSMUST00000135412.1
ENSMUST00000138365.1
ENSMUST00000145744.1
Pax6



paired box gene 6



chr16_+_14705832 1.683 ENSMUST00000023356.6
Snai2
snail homolog 2 (Drosophila)
chr11_-_45955183 1.669 ENSMUST00000109254.1
Thg1l
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
chr19_+_8953826 1.648 ENSMUST00000096239.5
Tut1
terminal uridylyl transferase 1, U6 snRNA-specific
chr7_-_128596278 1.550 ENSMUST00000179317.1
Gm7258
predicted gene 7258
chr10_-_80918212 1.477 ENSMUST00000057623.7
ENSMUST00000179022.1
Lmnb2

lamin B2

chr9_-_60649793 1.408 ENSMUST00000053171.7
Lrrc49
leucine rich repeat containing 49
chrX_+_56779437 1.256 ENSMUST00000114773.3
Fhl1
four and a half LIM domains 1
chr11_-_76509419 1.139 ENSMUST00000094012.4
Abr
active BCR-related gene
chr10_+_85928491 1.119 ENSMUST00000170396.1
Ascl4
achaete-scute complex homolog 4 (Drosophila)
chr11_+_95666957 1.091 ENSMUST00000125172.1
ENSMUST00000036374.5
Phb

prohibitin

chr5_+_32863700 1.086 ENSMUST00000149350.1
ENSMUST00000118698.1
ENSMUST00000150130.1
ENSMUST00000087897.4
ENSMUST00000119705.1
ENSMUST00000125574.1
ENSMUST00000049780.6
Depdc5






DEP domain containing 5






chr1_+_87327008 1.077 ENSMUST00000172794.1
ENSMUST00000164992.2
Gigyf2

GRB10 interacting GYF protein 2

chr2_+_3118335 1.072 ENSMUST00000115099.2
Fam171a1
family with sequence similarity 171, member A1
chr4_+_3938904 1.034 ENSMUST00000120732.1
ENSMUST00000041122.4
ENSMUST00000121651.1
ENSMUST00000121210.1
ENSMUST00000119307.1
ENSMUST00000123769.1
Chchd7





coiled-coil-helix-coiled-coil-helix domain containing 7





chr2_-_130629994 0.996 ENSMUST00000028761.4
ENSMUST00000110262.1
Ubox5
Fastkd5
U box domain containing 5
FAST kinase domains 5
chr11_+_117115133 0.973 ENSMUST00000021177.8
Sec14l1
SEC14-like 1 (S. cerevisiae)
chr1_-_172027251 0.849 ENSMUST00000138714.1
Vangl2
vang-like 2 (van gogh, Drosophila)
chr13_+_60601921 0.847 ENSMUST00000077453.5
Dapk1
death associated protein kinase 1
chr1_-_84935089 0.786 ENSMUST00000027422.5
Slc16a14
solute carrier family 16 (monocarboxylic acid transporters), member 14
chr11_-_69369377 0.775 ENSMUST00000092971.6
ENSMUST00000108661.1
Chd3

chromodomain helicase DNA binding protein 3

chr7_-_44257378 0.709 ENSMUST00000107945.1
ENSMUST00000118216.1
Acpt

acid phosphatase, testicular

chr13_-_67729109 0.689 ENSMUST00000073157.6
Zfp71-rs1
zinc finger protein 71, related sequence
chrX_+_164419782 0.679 ENSMUST00000033754.7
Piga
phosphatidylinositol glycan anchor biosynthesis, class A
chr1_-_54194048 0.676 ENSMUST00000120904.1
Hecw2
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
chrX_-_21089229 0.644 ENSMUST00000040667.6
Zfp300
zinc finger protein 300
chr11_+_117232254 0.642 ENSMUST00000106354.2
Sept9
septin 9
chr9_-_60687459 0.625 ENSMUST00000114032.1
ENSMUST00000166168.1
ENSMUST00000132366.1
Lrrc49


leucine rich repeat containing 49


chr4_-_88722454 0.608 ENSMUST00000094993.2
Klhl9
kelch-like 9
chr13_+_60602182 0.454 ENSMUST00000044083.7
Dapk1
death associated protein kinase 1
chr5_-_146963742 0.441 ENSMUST00000125217.1
ENSMUST00000110564.1
ENSMUST00000066675.3
ENSMUST00000016654.2
ENSMUST00000110566.1
ENSMUST00000140526.1
Mtif3





mitochondrial translational initiation factor 3





chr9_+_53771499 0.385 ENSMUST00000048670.8
Slc35f2
solute carrier family 35, member F2
chr11_+_117115195 0.311 ENSMUST00000103026.3
ENSMUST00000090433.5
Sec14l1

SEC14-like 1 (S. cerevisiae)

chr5_+_107597696 0.097 ENSMUST00000112651.1
ENSMUST00000112654.1
ENSMUST00000065422.5
Rpap2


RNA polymerase II associated protein 2


chr2_-_121806988 0.071 ENSMUST00000110592.1
Frmd5
FERM domain containing 5
chr8_-_41016295 0.060 ENSMUST00000131965.1
Mtus1
mitochondrial tumor suppressor 1
chr15_-_82047579 0.059 ENSMUST00000166578.1
ENSMUST00000080622.7
Nhp2l1

NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
9.7 58.3 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
4.3 13.0 GO:0046381 CMP-N-acetylneuraminate metabolic process(GO:0046381)
3.8 11.5 GO:1990046 positive regulation of mitochondrial DNA replication(GO:0090297) regulation of cardiolipin metabolic process(GO:1900208) positive regulation of cardiolipin metabolic process(GO:1900210) stress-induced mitochondrial fusion(GO:1990046)
1.7 8.3 GO:0019659 lactate biosynthetic process from pyruvate(GO:0019244) lactate biosynthetic process(GO:0019249) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
1.3 5.2 GO:0006166 purine ribonucleoside salvage(GO:0006166)
0.9 4.7 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171) prolactin signaling pathway(GO:0038161)
0.9 2.8 GO:0045410 positive regulation of interleukin-6 biosynthetic process(GO:0045410)
0.8 1.7 GO:1901420 negative regulation of response to alcohol(GO:1901420)
0.8 5.8 GO:0006344 maintenance of chromatin silencing(GO:0006344)
0.8 2.5 GO:0002295 T-helper cell lineage commitment(GO:0002295)
0.6 4.1 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.6 18.7 GO:0006270 DNA replication initiation(GO:0006270)
0.5 1.8 GO:0006547 histidine metabolic process(GO:0006547)
0.4 20.8 GO:0021884 forebrain neuron development(GO:0021884)
0.3 1.7 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918)
0.3 1.3 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.3 5.2 GO:0010566 regulation of ketone biosynthetic process(GO:0010566)
0.3 0.8 GO:0060489 establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105) orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490) non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346)
0.3 1.6 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.3 6.5 GO:0097352 autophagosome maturation(GO:0097352)
0.2 4.8 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.2 1.1 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313)
0.2 1.1 GO:0002922 positive regulation of humoral immune response(GO:0002922) progesterone receptor signaling pathway(GO:0050847)
0.2 4.0 GO:0034063 stress granule assembly(GO:0034063)
0.2 1.8 GO:0006527 arginine catabolic process(GO:0006527)
0.1 0.4 GO:0070124 mitochondrial translational initiation(GO:0070124)
0.1 2.2 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.1 1.0 GO:0000963 mitochondrial RNA processing(GO:0000963)
0.1 5.4 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.1 2.1 GO:0019430 removal of superoxide radicals(GO:0019430)
0.1 1.1 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.1 1434.9 GO:0008150 biological_process(GO:0008150)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 20.8 GO:0001674 female germ cell nucleus(GO:0001674)
0.9 3.4 GO:0032021 NELF complex(GO:0032021)
0.8 2.5 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.7 11.5 GO:0042101 T cell receptor complex(GO:0042101)
0.6 8.3 GO:0035686 sperm fibrous sheath(GO:0035686)
0.4 4.1 GO:0001739 sex chromatin(GO:0001739)
0.4 2.2 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.3 5.8 GO:0071564 npBAF complex(GO:0071564)
0.3 3.1 GO:0031080 nuclear pore outer ring(GO:0031080)
0.3 1.1 GO:1990130 Iml1 complex(GO:1990130)
0.2 0.8 GO:0060187 cell pole(GO:0060187)
0.2 1.5 GO:0005638 lamin filament(GO:0005638)
0.2 11.2 GO:0005876 spindle microtubule(GO:0005876)
0.2 2.1 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.1 1.1 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.1 1.9 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.1 1.6 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.1 4.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 1535.7 GO:0005575 cellular_component(GO:0005575)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.3 13.0 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
3.8 11.5 GO:1901611 phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)
2.1 8.3 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
1.7 5.2 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.6 11.2 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.6 4.7 GO:0008193 tRNA guanylyltransferase activity(GO:0008193)
0.4 4.0 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.4 1.1 GO:0031871 proteinase activated receptor binding(GO:0031871)
0.4 6.3 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.3 5.2 GO:0070403 NAD+ binding(GO:0070403)
0.3 1.6 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.3 2.5 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.3 1.8 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.3 1.8 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.3 2.2 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.3 2.1 GO:0008097 5S rRNA binding(GO:0008097)
0.2 2.8 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.2 40.2 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.2 3.1 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.2 4.8 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.2 4.0 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 4.7 GO:0017046 peptide hormone binding(GO:0017046)
0.1 5.8 GO:0031491 nucleosome binding(GO:0031491)
0.1 1482.6 GO:0003674 molecular_function(GO:0003674)