Motif ID: Hdx
Z-value: 6.749
Transcription factors associated with Hdx:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Hdx | ENSMUSG00000034551.6 | Hdx |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hdx | mm10_v2_chrX_-_111697069_111697127 | -0.15 | 3.9e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.7 | 58.3 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
| 4.3 | 13.0 | GO:0046381 | CMP-N-acetylneuraminate metabolic process(GO:0046381) |
| 3.8 | 11.5 | GO:1990046 | positive regulation of mitochondrial DNA replication(GO:0090297) regulation of cardiolipin metabolic process(GO:1900208) positive regulation of cardiolipin metabolic process(GO:1900210) stress-induced mitochondrial fusion(GO:1990046) |
| 1.7 | 8.3 | GO:0019659 | lactate biosynthetic process from pyruvate(GO:0019244) lactate biosynthetic process(GO:0019249) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661) |
| 1.3 | 5.2 | GO:0006166 | purine ribonucleoside salvage(GO:0006166) |
| 0.9 | 4.7 | GO:0007171 | activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171) prolactin signaling pathway(GO:0038161) |
| 0.9 | 2.8 | GO:0045410 | positive regulation of interleukin-6 biosynthetic process(GO:0045410) |
| 0.8 | 1.7 | GO:1901420 | negative regulation of response to alcohol(GO:1901420) |
| 0.8 | 5.8 | GO:0006344 | maintenance of chromatin silencing(GO:0006344) |
| 0.8 | 2.5 | GO:0002295 | T-helper cell lineage commitment(GO:0002295) |
| 0.6 | 4.1 | GO:0061087 | positive regulation of histone H3-K27 methylation(GO:0061087) |
| 0.6 | 18.7 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.5 | 1.8 | GO:0006547 | histidine metabolic process(GO:0006547) |
| 0.4 | 20.8 | GO:0021884 | forebrain neuron development(GO:0021884) |
| 0.3 | 1.7 | GO:0021905 | pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) |
| 0.3 | 1.3 | GO:0039536 | negative regulation of RIG-I signaling pathway(GO:0039536) |
| 0.3 | 5.2 | GO:0010566 | regulation of ketone biosynthetic process(GO:0010566) |
| 0.3 | 0.8 | GO:0060489 | establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105) orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490) non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346) |
| 0.3 | 1.6 | GO:0098789 | pre-mRNA cleavage required for polyadenylation(GO:0098789) |
| 0.3 | 6.5 | GO:0097352 | autophagosome maturation(GO:0097352) |
| 0.2 | 4.8 | GO:0010763 | positive regulation of fibroblast migration(GO:0010763) |
| 0.2 | 1.1 | GO:0043314 | negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313) |
| 0.2 | 1.1 | GO:0002922 | positive regulation of humoral immune response(GO:0002922) progesterone receptor signaling pathway(GO:0050847) |
| 0.2 | 4.0 | GO:0034063 | stress granule assembly(GO:0034063) |
| 0.2 | 1.8 | GO:0006527 | arginine catabolic process(GO:0006527) |
| 0.1 | 0.4 | GO:0070124 | mitochondrial translational initiation(GO:0070124) |
| 0.1 | 2.2 | GO:2000001 | regulation of DNA damage checkpoint(GO:2000001) |
| 0.1 | 1.0 | GO:0000963 | mitochondrial RNA processing(GO:0000963) |
| 0.1 | 5.4 | GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle(GO:2000134) |
| 0.1 | 2.1 | GO:0019430 | removal of superoxide radicals(GO:0019430) |
| 0.1 | 1.1 | GO:1904262 | negative regulation of TORC1 signaling(GO:1904262) |
| 0.1 | 1434.9 | GO:0008150 | biological_process(GO:0008150) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.5 | 20.8 | GO:0001674 | female germ cell nucleus(GO:0001674) |
| 0.9 | 3.4 | GO:0032021 | NELF complex(GO:0032021) |
| 0.8 | 2.5 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 0.7 | 11.5 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 0.6 | 8.3 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.4 | 4.1 | GO:0001739 | sex chromatin(GO:0001739) |
| 0.4 | 2.2 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
| 0.3 | 5.8 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.3 | 3.1 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
| 0.3 | 1.1 | GO:1990130 | Iml1 complex(GO:1990130) |
| 0.2 | 0.8 | GO:0060187 | cell pole(GO:0060187) |
| 0.2 | 1.5 | GO:0005638 | lamin filament(GO:0005638) |
| 0.2 | 11.2 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.2 | 2.1 | GO:0043240 | Fanconi anaemia nuclear complex(GO:0043240) |
| 0.1 | 1.1 | GO:0031315 | extrinsic component of mitochondrial outer membrane(GO:0031315) |
| 0.1 | 1.9 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 0.1 | 1.6 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
| 0.1 | 4.3 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.1 | 1535.7 | GO:0005575 | cellular_component(GO:0005575) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.3 | 13.0 | GO:0016716 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716) |
| 3.8 | 11.5 | GO:1901611 | phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612) |
| 2.1 | 8.3 | GO:0004459 | L-lactate dehydrogenase activity(GO:0004459) |
| 1.7 | 5.2 | GO:0004731 | purine-nucleoside phosphorylase activity(GO:0004731) |
| 0.6 | 11.2 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.6 | 4.7 | GO:0008193 | tRNA guanylyltransferase activity(GO:0008193) |
| 0.4 | 4.0 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.4 | 1.1 | GO:0031871 | proteinase activated receptor binding(GO:0031871) |
| 0.4 | 6.3 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.3 | 5.2 | GO:0070403 | NAD+ binding(GO:0070403) |
| 0.3 | 1.6 | GO:0050265 | RNA uridylyltransferase activity(GO:0050265) |
| 0.3 | 2.5 | GO:0005138 | interleukin-6 receptor binding(GO:0005138) |
| 0.3 | 1.8 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
| 0.3 | 1.8 | GO:0016813 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813) |
| 0.3 | 2.2 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
| 0.3 | 2.1 | GO:0008097 | 5S rRNA binding(GO:0008097) |
| 0.2 | 2.8 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.2 | 40.2 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.2 | 3.1 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
| 0.2 | 4.8 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.2 | 4.0 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.1 | 4.7 | GO:0017046 | peptide hormone binding(GO:0017046) |
| 0.1 | 5.8 | GO:0031491 | nucleosome binding(GO:0031491) |
| 0.1 | 1482.6 | GO:0003674 | molecular_function(GO:0003674) |
