Motif ID: Hes1

Z-value: 1.087


Transcription factors associated with Hes1:

Gene SymbolEntrez IDGene Name
Hes1 ENSMUSG00000022528.7 Hes1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hes1mm10_v2_chr16_+_30065333_300653510.833.1e-09Click!


Activity profile for motif Hes1.

activity profile for motif Hes1


Sorted Z-values histogram for motif Hes1

Sorted Z-values for motif Hes1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hes1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_12026237 11.497 ENSMUST00000150972.1
 Grb10
growth factor receptor bound protein 10
chr11_-_12026732 10.198 ENSMUST00000143915.1
 Grb10
growth factor receptor bound protein 10
chr4_+_65124174 4.420 ENSMUST00000084501.3
 Pappa
pregnancy-associated plasma protein A
chr17_-_25797032 3.728 ENSMUST00000165838.1
ENSMUST00000002344.6
 Metrn

meteorin, glial cell differentiation regulator

chr1_+_153652943 3.667 ENSMUST00000041776.5
 Rgs8
regulator of G-protein signaling 8
chr19_+_60144682 3.273 ENSMUST00000065383.4
 E330013P04Rik
RIKEN cDNA E330013P04 gene
chr12_+_110279228 2.812 ENSMUST00000097228.4
 Dio3
deiodinase, iodothyronine type III
chr11_-_89302545 2.801 ENSMUST00000061728.3
 Nog
noggin
chrX_-_141725181 2.723 ENSMUST00000067841.7
 Irs4
insulin receptor substrate 4
chr1_-_166309585 2.705 ENSMUST00000168347.1
 5330438I03Rik
RIKEN cDNA 5330438I03 gene
chr8_+_119446719 2.566 ENSMUST00000098363.3
 Necab2
N-terminal EF-hand calcium binding protein 2
chr1_-_175692624 2.362 ENSMUST00000027809.7
 Opn3
opsin 3
chr7_+_45017953 2.306 ENSMUST00000044111.7
 Rras
Harvey rat sarcoma oncogene, subgroup R
chr8_+_106603351 2.207 ENSMUST00000000312.5
ENSMUST00000167688.1
 Cdh1

cadherin 1

chr4_+_116877376 2.145 ENSMUST00000044823.3
 Zswim5
zinc finger SWIM-type containing 5
chr16_-_97922582 2.132 ENSMUST00000170757.1
 C2cd2
C2 calcium-dependent domain containing 2
chr9_-_75409951 2.082 ENSMUST00000049355.10
 Mapk6
mitogen-activated protein kinase 6
chr12_-_111485808 2.068 ENSMUST00000010673.5
 Gm266
predicted gene 266
chr2_+_156840966 1.988 ENSMUST00000109564.1
 Tgif2
TGFB-induced factor homeobox 2
chr11_-_116828000 1.982 ENSMUST00000047715.5
ENSMUST00000021170.2
 Mxra7

matrix-remodelling associated 7


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 153 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.4 21.7 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.3 3.7 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.5 3.3 GO:0035087 siRNA loading onto RISC involved in RNA interference(GO:0035087)
0.8 3.2 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.7 2.8 GO:0003360 brainstem development(GO:0003360)
0.7 2.8 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
0.5 2.8 GO:0019336 phenol-containing compound catabolic process(GO:0019336)
0.0 2.8 GO:0051028 mRNA transport(GO:0051028)
0.4 2.6 GO:0001842 neural fold formation(GO:0001842)
0.3 2.6 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 2.6 GO:0019216 regulation of lipid metabolic process(GO:0019216)
0.2 2.5 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.8 2.4 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 2.4 GO:0050772 positive regulation of axonogenesis(GO:0050772)
0.1 2.3 GO:0060325 face morphogenesis(GO:0060325)
0.4 2.2 GO:0060066 oviduct development(GO:0060066)
0.4 2.1 GO:1900085 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085)
0.0 2.1 GO:0031960 response to corticosteroid(GO:0031960) response to glucocorticoid(GO:0051384)
0.7 2.0 GO:0009177 deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177)
0.1 2.0 GO:0038092 nodal signaling pathway(GO:0038092)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 77 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.3 GO:0005667 transcription factor complex(GO:0005667)
0.1 3.7 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 3.5 GO:0030139 endocytic vesicle(GO:0030139)
0.9 2.8 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.5 2.6 GO:0044611 nuclear pore inner ring(GO:0044611)
0.2 2.6 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 2.5 GO:0031225 anchored component of membrane(GO:0031225)
0.2 2.2 GO:0016342 catenin complex(GO:0016342)
0.1 2.1 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 2.1 GO:0032156 septin cytoskeleton(GO:0032156)
0.1 2.1 GO:0005719 nuclear euchromatin(GO:0005719)
0.3 2.0 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.0 2.0 GO:0031519 PcG protein complex(GO:0031519)
0.5 1.9 GO:0090537 CERF complex(GO:0090537)
0.0 1.9 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 1.8 GO:0034399 nuclear periphery(GO:0034399)
0.1 1.7 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 1.7 GO:0008180 COP9 signalosome(GO:0008180)
0.0 1.7 GO:0005844 polysome(GO:0005844)
0.5 1.6 GO:0036488 CHOP-C/EBP complex(GO:0036488)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 110 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 21.7 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 3.7 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 3.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.5 3.2 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.0 3.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.2 2.9 GO:0051920 peroxiredoxin activity(GO:0051920)
0.5 2.8 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.0 2.8 GO:0019955 cytokine binding(GO:0019955)
0.1 2.7 GO:0005158 insulin receptor binding(GO:0005158)
0.4 2.6 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 2.6 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.8 2.4 GO:0009881 photoreceptor activity(GO:0009881)
0.1 2.4 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 2.3 GO:0019003 GDP binding(GO:0019003)
0.7 2.2 GO:0008732 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.2 2.2 GO:0045294 alpha-catenin binding(GO:0045294)
0.4 2.1 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.3 2.0 GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733)
0.1 2.0 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 2.0 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)