Motif ID: Hey1_Myc_Mxi1

Z-value: 1.291

Transcription factors associated with Hey1_Myc_Mxi1:

Gene SymbolEntrez IDGene Name
Hey1 ENSMUSG00000040289.3 Hey1
Mxi1 ENSMUSG00000025025.7 Mxi1
Myc ENSMUSG00000022346.8 Myc

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mxi1mm10_v2_chr19_+_53329413_53329478-0.894.1e-12Click!
Mycmm10_v2_chr15_+_61987034_61987059-0.512.6e-03Click!
Hey1mm10_v2_chr3_-_8667033_86670460.271.4e-01Click!


Activity profile for motif Hey1_Myc_Mxi1.

activity profile for motif Hey1_Myc_Mxi1


Sorted Z-values histogram for motif Hey1_Myc_Mxi1

Sorted Z-values for motif Hey1_Myc_Mxi1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hey1_Myc_Mxi1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_43239816 11.061 ENSMUST00000034512.5
 Oaf
OAF homolog (Drosophila)
chr10_+_127063599 9.398 ENSMUST00000120226.1
ENSMUST00000133115.1
 Cdk4

cyclin-dependent kinase 4

chr2_-_92370999 9.200 ENSMUST00000176810.1
ENSMUST00000090582.4
 Gyltl1b

glycosyltransferase-like 1B

chr3_+_107595031 8.962 ENSMUST00000014747.1
 Alx3
aristaless-like homeobox 3
chr19_+_56874249 8.941 ENSMUST00000026068.7
 Vwa2
von Willebrand factor A domain containing 2
chr12_+_109459843 8.678 ENSMUST00000173812.1
 Dlk1
delta-like 1 homolog (Drosophila)
chrX_+_73639414 8.607 ENSMUST00000019701.8
 Dusp9
dual specificity phosphatase 9
chr10_+_127063527 8.203 ENSMUST00000006911.5
 Cdk4
cyclin-dependent kinase 4
chr4_-_11386757 8.137 ENSMUST00000108313.1
ENSMUST00000108311.2
 Esrp1

epithelial splicing regulatory protein 1

chr5_-_137314175 8.053 ENSMUST00000024119.9
 Trip6
thyroid hormone receptor interactor 6
chr10_+_22158566 8.008 ENSMUST00000181645.1
ENSMUST00000105522.2
 Raet1e
H60b
retinoic acid early transcript 1E
histocompatibility 60b
chrX_-_141725181 7.617 ENSMUST00000067841.7
 Irs4
insulin receptor substrate 4
chr14_-_20181773 7.554 ENSMUST00000024011.8
 Kcnk5
potassium channel, subfamily K, member 5
chr2_-_92371039 7.481 ENSMUST00000068586.6
 Gyltl1b
glycosyltransferase-like 1B
chr3_-_90052463 7.356 ENSMUST00000029553.9
ENSMUST00000064639.8
ENSMUST00000090908.6
 Ubap2l


ubiquitin associated protein 2-like


chr11_-_12026237 7.063 ENSMUST00000150972.1
 Grb10
growth factor receptor bound protein 10
chr15_-_43170809 7.056 ENSMUST00000063492.6
 Rspo2
R-spondin 2 homolog (Xenopus laevis)
chr5_-_76951560 7.038 ENSMUST00000140076.1
 Ppat
phosphoribosyl pyrophosphate amidotransferase
chr4_+_101419696 6.949 ENSMUST00000131397.1
ENSMUST00000133055.1
 Ak4

adenylate kinase 4

chr3_-_95882031 6.866 ENSMUST00000161994.1
 Gm129
predicted gene 129

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 509 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 23.1 GO:0035269 protein O-linked mannosylation(GO:0035269)
4.4 17.6 GO:0010288 response to lead ion(GO:0010288)
0.2 17.1 GO:0007601 visual perception(GO:0007601)
0.4 16.2 GO:0030490 maturation of SSU-rRNA(GO:0030490)
2.7 13.4 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
1.3 13.4 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
1.5 13.3 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
2.1 12.3 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.5 11.2 GO:0006907 pinocytosis(GO:0006907)
0.3 11.2 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.2 10.3 GO:0006405 RNA export from nucleus(GO:0006405)
1.7 10.2 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.2 10.1 GO:0006446 regulation of translational initiation(GO:0006446)
1.1 10.0 GO:0010587 miRNA catabolic process(GO:0010587)
3.3 9.9 GO:0090194 negative regulation of glomerular mesangial cell proliferation(GO:0072125) negative regulation of glomerulus development(GO:0090194)
0.6 9.3 GO:1904816 positive regulation of protein localization to chromosome, telomeric region(GO:1904816)
3.1 9.2 GO:0042822 vitamin B6 metabolic process(GO:0042816) pyridoxal phosphate metabolic process(GO:0042822) pyridoxal phosphate biosynthetic process(GO:0042823)
0.4 9.2 GO:0035115 embryonic forelimb morphogenesis(GO:0035115)
0.4 9.0 GO:0001913 T cell mediated cytotoxicity(GO:0001913)
3.0 8.9 GO:0007161 calcium-independent cell-matrix adhesion(GO:0007161)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 236 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 80.8 GO:0070062 extracellular exosome(GO:0070062)
0.1 35.0 GO:0005925 focal adhesion(GO:0005925)
0.5 23.9 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 23.0 GO:0005730 nucleolus(GO:0005730)
0.3 15.1 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 14.2 GO:0005604 basement membrane(GO:0005604)
1.0 13.8 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 13.3 GO:0005615 extracellular space(GO:0005615)
0.2 12.4 GO:0005758 mitochondrial intermembrane space(GO:0005758)
1.2 11.6 GO:0005642 annulate lamellae(GO:0005642)
1.6 11.2 GO:0097422 tubular endosome(GO:0097422)
0.5 10.7 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
1.3 10.4 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 9.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
1.0 9.4 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.6 9.4 GO:0034719 SMN-Sm protein complex(GO:0034719)
1.8 9.1 GO:0044611 nuclear pore inner ring(GO:0044611)
1.0 8.3 GO:0031415 NatA complex(GO:0031415)
0.4 8.3 GO:0030686 90S preribosome(GO:0030686)
0.1 8.1 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 355 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 51.2 GO:0044822 poly(A) RNA binding(GO:0044822)
4.7 23.4 GO:0018121 imidazoleglycerol-phosphate synthase activity(GO:0000107) NAD(P)-cysteine ADP-ribosyltransferase activity(GO:0018071) NAD(P)-asparagine ADP-ribosyltransferase activity(GO:0018121) NAD(P)-serine ADP-ribosyltransferase activity(GO:0018127) 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity(GO:0043867) purine deoxyribosyltransferase activity(GO:0044102)
0.5 20.9 GO:0016831 carboxy-lyase activity(GO:0016831)
0.4 16.4 GO:0030332 cyclin binding(GO:0030332)
1.5 15.0 GO:0070700 BMP receptor binding(GO:0070700)
0.6 13.3 GO:0001784 phosphotyrosine binding(GO:0001784)
2.1 12.3 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
1.0 11.7 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.9 11.6 GO:0017070 U6 snRNA binding(GO:0017070)
3.8 11.5 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.2 11.2 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
3.6 10.9 GO:0005118 sevenless binding(GO:0005118)
0.5 10.7 GO:0001056 RNA polymerase III activity(GO:0001056)
0.2 10.7 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.3 10.4 GO:0008536 Ran GTPase binding(GO:0008536)
0.2 10.0 GO:0003725 double-stranded RNA binding(GO:0003725)
0.5 9.7 GO:0017056 structural constituent of nuclear pore(GO:0017056)
1.3 9.0 GO:0034452 dynactin binding(GO:0034452)
0.6 9.0 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.2 8.9 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)