Motif ID: Hey2

Z-value: 0.758


Transcription factors associated with Hey2:

Gene SymbolEntrez IDGene Name
Hey2 ENSMUSG00000019789.8 Hey2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hey2mm10_v2_chr10_-_30842765_308428010.484.6e-03Click!


Activity profile for motif Hey2.

activity profile for motif Hey2


Sorted Z-values histogram for motif Hey2

Sorted Z-values for motif Hey2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hey2

PNG image of the network

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Top targets:


Showing 1 to 20 of 178 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_88875035 5.067 ENSMUST00000145944.1
 Podxl2
podocalyxin-like 2
chr13_-_14523178 4.648 ENSMUST00000110516.2
 Hecw1
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
chr11_+_113619318 4.642 ENSMUST00000146390.2
ENSMUST00000106630.1
 Sstr2

somatostatin receptor 2

chr4_+_33924632 3.587 ENSMUST00000057188.6
 Cnr1
cannabinoid receptor 1 (brain)
chr8_-_70700070 3.271 ENSMUST00000116172.1
 Gm11175
predicted gene 11175
chr6_+_54816906 3.166 ENSMUST00000079869.6
 Znrf2
zinc and ring finger 2
chr2_-_168741898 3.030 ENSMUST00000109176.1
ENSMUST00000178504.1
 Atp9a

ATPase, class II, type 9A

chr16_-_18621366 2.961 ENSMUST00000051160.2
 Gp1bb
glycoprotein Ib, beta polypeptide
chr4_+_104367549 2.902 ENSMUST00000106830.2
 Dab1
disabled 1
chr3_+_105452326 2.898 ENSMUST00000098761.3
 Kcnd3
potassium voltage-gated channel, Shal-related family, member 3
chr2_+_128967383 2.774 ENSMUST00000110320.2
ENSMUST00000110319.2
 Zc3h6

zinc finger CCCH type containing 6

chr1_+_23762003 2.669 ENSMUST00000140583.1
 B3gat2
beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S)
chr11_+_120348678 2.647 ENSMUST00000143813.1
 0610009L18Rik
RIKEN cDNA 0610009L18 gene
chr7_-_25658726 2.512 ENSMUST00000071329.6
 Bckdha
branched chain ketoacid dehydrogenase E1, alpha polypeptide
chr2_-_114013619 2.503 ENSMUST00000090275.4
 Gjd2
gap junction protein, delta 2
chr4_+_129984833 2.454 ENSMUST00000120204.1
 Bai2
brain-specific angiogenesis inhibitor 2
chr18_-_61911783 2.404 ENSMUST00000049378.8
ENSMUST00000166783.1
 Ablim3

actin binding LIM protein family, member 3

chr4_+_129985098 2.349 ENSMUST00000106017.1
ENSMUST00000121049.1
 Bai2

brain-specific angiogenesis inhibitor 2

chr19_+_6418731 2.343 ENSMUST00000113462.1
ENSMUST00000077182.6
ENSMUST00000113461.1
 Nrxn2


neurexin II


chr6_-_88874597 2.307 ENSMUST00000061262.4
ENSMUST00000140455.1
ENSMUST00000145780.1
 Podxl2


podocalyxin-like 2



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 82 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 7.1 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.1 5.6 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 5.1 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.5 4.6 GO:0030432 peristalsis(GO:0030432)
0.2 4.5 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.1 3.9 GO:0050868 negative regulation of T cell activation(GO:0050868)
0.9 3.6 GO:0031622 positive regulation of fever generation(GO:0031622)
0.1 3.5 GO:0045214 sarcomere organization(GO:0045214)
0.4 3.2 GO:0021894 cerebral cortex GABAergic interneuron development(GO:0021894)
0.0 3.0 GO:0007596 blood coagulation(GO:0007596)
1.0 2.9 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.3 2.9 GO:0071435 potassium ion export(GO:0071435)
0.2 2.5 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.0 2.5 GO:0007601 visual perception(GO:0007601)
0.0 2.4 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.8 2.3 GO:0003349 epicardium-derived cardiac endothelial cell differentiation(GO:0003349)
0.4 2.3 GO:0035428 hexose transmembrane transport(GO:0035428)
0.2 2.1 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.2 2.0 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.6 1.9 GO:0031652 positive regulation of heat generation(GO:0031652)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 11.0 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 6.7 GO:0031941 filamentous actin(GO:0031941)
0.0 6.6 GO:0055037 recycling endosome(GO:0055037)
0.0 3.2 GO:0030659 cytoplasmic vesicle membrane(GO:0030659)
0.1 2.9 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 2.9 GO:0042734 presynaptic membrane(GO:0042734)
0.0 2.9 GO:0005903 brush border(GO:0005903)
0.6 2.5 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.2 2.5 GO:0005922 connexon complex(GO:0005922)
0.1 2.3 GO:0090544 BAF-type complex(GO:0090544)
0.0 2.3 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.2 2.1 GO:0031209 SCAR complex(GO:0031209)
0.4 1.8 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1 1.8 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 1.7 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.2 1.1 GO:0005638 lamin filament(GO:0005638)
0.1 1.1 GO:0002102 podosome(GO:0002102)
0.3 1.0 GO:0044194 cytolytic granule(GO:0044194)
0.0 1.0 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.8 GO:0032588 trans-Golgi network membrane(GO:0032588)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.1 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.2 5.0 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
1.5 4.6 GO:0004994 somatostatin receptor activity(GO:0004994)
0.7 4.5 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.1 4.3 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.4 3.9 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 3.2 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.6 2.9 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.1 2.9 GO:0042169 SH2 domain binding(GO:0042169)
0.0 2.9 GO:0008144 drug binding(GO:0008144)
0.2 2.5 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.2 2.3 GO:0005355 glucose transmembrane transporter activity(GO:0005355)
0.1 2.3 GO:0070064 proline-rich region binding(GO:0070064)
0.0 2.3 GO:0005246 calcium channel regulator activity(GO:0005246)
0.5 2.0 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.2 1.9 GO:0015245 fatty acid transporter activity(GO:0015245)
0.4 1.8 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0 1.8 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.3 1.7 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.3 1.6 GO:0016453 acetyl-CoA C-acetyltransferase activity(GO:0003985) C-acetyltransferase activity(GO:0016453)