Motif ID: Hic2

Z-value: 1.850


Transcription factors associated with Hic2:

Gene SymbolEntrez IDGene Name
Hic2 ENSMUSG00000050240.8 Hic2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hic2mm10_v2_chr16_+_17233560_17233664-0.662.6e-05Click!


Activity profile for motif Hic2.

activity profile for motif Hic2


Sorted Z-values histogram for motif Hic2

Sorted Z-values for motif Hic2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hic2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_64046925 15.184 ENSMUST00000107377.3
 Tnc
tenascin C
chr11_+_104231390 13.624 ENSMUST00000106992.3
 Mapt
microtubule-associated protein tau
chr11_+_104231573 12.646 ENSMUST00000132977.1
ENSMUST00000132245.1
ENSMUST00000100347.4
 Mapt


microtubule-associated protein tau


chr11_+_78324200 12.616 ENSMUST00000102478.3
 Aldoc
aldolase C, fructose-bisphosphate
chr5_+_98180866 11.612 ENSMUST00000112959.1
 Prdm8
PR domain containing 8
chr11_+_104231515 11.148 ENSMUST00000106993.3
 Mapt
microtubule-associated protein tau
chr6_+_103510874 10.491 ENSMUST00000066905.6
 Chl1
cell adhesion molecule with homology to L1CAM
chr11_+_104231465 10.208 ENSMUST00000145227.1
 Mapt
microtubule-associated protein tau
chr1_+_185454803 9.430 ENSMUST00000061093.6
 Slc30a10
solute carrier family 30, member 10
chr12_+_16653470 9.265 ENSMUST00000111064.1
 Ntsr2
neurotensin receptor 2
chr10_+_127725392 9.108 ENSMUST00000026466.3
 Tac2
tachykinin 2
chr18_-_23038656 8.738 ENSMUST00000081423.6
 Nol4
nucleolar protein 4
chr7_+_130936172 8.354 ENSMUST00000006367.7
 Htra1
HtrA serine peptidase 1
chr15_+_92051153 8.006 ENSMUST00000169825.1
 Cntn1
contactin 1
chr8_+_72646679 7.761 ENSMUST00000161386.1
ENSMUST00000093427.4
 Nwd1

NACHT and WD repeat domain containing 1

chr3_+_105452326 7.527 ENSMUST00000098761.3
 Kcnd3
potassium voltage-gated channel, Shal-related family, member 3
chr1_+_74854954 7.382 ENSMUST00000160379.2
 Cdk5r2
cyclin-dependent kinase 5, regulatory subunit 2 (p39)
chr9_+_45430293 7.300 ENSMUST00000034592.8
 Dscaml1
Down syndrome cell adhesion molecule like 1
chr1_-_134234492 7.118 ENSMUST00000169927.1
 Adora1
adenosine A1 receptor
chr12_+_61523889 6.728 ENSMUST00000119481.1
ENSMUST00000055815.7
 Lrfn5

leucine rich repeat and fibronectin type III domain containing 5


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 362 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.0 48.6 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
3.8 15.2 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
1.0 15.1 GO:0021957 corticospinal tract morphogenesis(GO:0021957)
4.3 13.0 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256)
1.3 12.6 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.8 12.1 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.3 10.5 GO:0035640 exploration behavior(GO:0035640)
0.6 10.4 GO:0045792 negative regulation of cell size(GO:0045792)
0.4 10.2 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
1.0 9.2 GO:0061088 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
1.5 9.1 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
1.8 9.0 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.9 8.7 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.4 8.6 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
1.4 8.4 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
0.9 7.5 GO:0071435 potassium ion export(GO:0071435)
1.8 7.4 GO:0021586 pons maturation(GO:0021586)
0.9 7.3 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
1.7 6.9 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
1.4 6.8 GO:0010624 regulation of Schwann cell proliferation(GO:0010624)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 145 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.8 47.6 GO:0045298 tubulin complex(GO:0045298)
0.1 25.9 GO:0031012 extracellular matrix(GO:0031012)
1.3 21.4 GO:0005614 interstitial matrix(GO:0005614)
0.8 18.4 GO:0098984 neuron to neuron synapse(GO:0098984)
0.3 16.7 GO:0042734 presynaptic membrane(GO:0042734)
0.2 16.0 GO:0000118 histone deacetylase complex(GO:0000118)
0.2 13.9 GO:0043198 dendritic shaft(GO:0043198)
0.1 12.9 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.4 12.8 GO:0060077 inhibitory synapse(GO:0060077)
0.1 12.7 GO:0031225 anchored component of membrane(GO:0031225)
0.2 12.3 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.4 11.9 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.3 10.9 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 10.3 GO:0035097 histone methyltransferase complex(GO:0035097)
0.1 10.2 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.4 9.7 GO:0030673 axolemma(GO:0030673)
0.8 9.2 GO:0031931 TORC1 complex(GO:0031931)
0.8 8.7 GO:0002116 semaphorin receptor complex(GO:0002116)
0.3 8.0 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
2.5 7.4 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 245 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 50.7 GO:0034185 apolipoprotein binding(GO:0034185)
2.5 15.2 GO:0045545 syndecan binding(GO:0045545)
1.9 13.0 GO:0032795 G-protein coupled adenosine receptor activity(GO:0001609) heterotrimeric G-protein binding(GO:0032795)
0.1 12.8 GO:0005178 integrin binding(GO:0005178)
2.1 12.6 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.8 12.4 GO:0008188 neuropeptide receptor activity(GO:0008188)
1.5 11.6 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
1.0 11.1 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.3 10.9 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.2 9.6 GO:0001540 beta-amyloid binding(GO:0001540)
0.1 9.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.3 9.2 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 9.2 GO:0002020 protease binding(GO:0002020)
0.4 8.8 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.6 8.7 GO:0017154 semaphorin receptor activity(GO:0017154)
0.4 8.6 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
1.3 7.6 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
1.5 7.5 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
2.4 7.3 GO:0046997 sarcosine dehydrogenase activity(GO:0008480) oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor(GO:0046997)
0.8 7.3 GO:0032050 clathrin heavy chain binding(GO:0032050)