Motif ID: Hlf

Z-value: 0.906


Transcription factors associated with Hlf:

Gene SymbolEntrez IDGene Name
Hlf ENSMUSG00000003949.10 Hlf

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hlfmm10_v2_chr11_-_90390895_903909260.699.1e-06Click!


Activity profile for motif Hlf.

activity profile for motif Hlf


Sorted Z-values histogram for motif Hlf

Sorted Z-values for motif Hlf



Network of associatons between targets according to the STRING database.



First level regulatory network of Hlf

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_+_65971049 6.522 ENSMUST00000128539.1
 Clu
clusterin
chr14_+_65970804 6.110 ENSMUST00000138191.1
 Clu
clusterin
chr14_+_65971164 5.845 ENSMUST00000144619.1
 Clu
clusterin
chr15_-_88978958 5.795 ENSMUST00000042594.6
ENSMUST00000109368.1
 Mlc1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

chr4_-_151044564 3.615 ENSMUST00000103204.4
 Per3
period circadian clock 3
chr10_+_94576254 3.435 ENSMUST00000117929.1
 Tmcc3
transmembrane and coiled coil domains 3
chr17_-_31637135 3.375 ENSMUST00000118504.1
ENSMUST00000078509.5
ENSMUST00000067801.6
 Cbs


cystathionine beta-synthase


chr11_-_101785252 3.356 ENSMUST00000164750.1
ENSMUST00000107176.1
ENSMUST00000017868.6
 Etv4


ets variant gene 4 (E1A enhancer binding protein, E1AF)


chr9_-_107668967 3.280 ENSMUST00000177567.1
 Slc38a3
solute carrier family 38, member 3
chr18_-_80713062 3.274 ENSMUST00000170905.1
ENSMUST00000078049.4
 Nfatc1

nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1

chr6_+_90465287 2.754 ENSMUST00000113530.1
 Klf15
Kruppel-like factor 15
chr9_+_94669876 2.530 ENSMUST00000033463.9
 Slc9a9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr19_-_50678642 2.368 ENSMUST00000072685.6
ENSMUST00000164039.2
 Sorcs1

VPS10 domain receptor protein SORCS 1

chr3_+_127553462 2.359 ENSMUST00000043108.4
 4930422G04Rik
RIKEN cDNA 4930422G04 gene
chr7_+_110773658 2.185 ENSMUST00000143786.1
 Ampd3
adenosine monophosphate deaminase 3
chr13_+_49504774 2.144 ENSMUST00000051504.7
 Ecm2
extracellular matrix protein 2, female organ and adipocyte specific
chr10_-_70592782 1.907 ENSMUST00000162251.1
 Phyhipl
phytanoyl-CoA hydroxylase interacting protein-like
chr11_+_110997487 1.865 ENSMUST00000106635.1
 Kcnj16
potassium inwardly-rectifying channel, subfamily J, member 16
chr15_+_25758755 1.829 ENSMUST00000131834.1
ENSMUST00000124966.1
 Myo10

myosin X

chr18_+_50030977 1.806 ENSMUST00000145726.1
ENSMUST00000128377.1
 Tnfaip8

tumor necrosis factor, alpha-induced protein 8


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 92 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.1 18.5 GO:1902847 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of tau-protein kinase activity(GO:1902949)
1.4 6.8 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.2 5.3 GO:0010107 potassium ion import(GO:0010107)
0.5 3.9 GO:0032264 IMP salvage(GO:0032264)
0.2 3.6 GO:0045187 regulation of circadian sleep/wake cycle, sleep(GO:0045187)
1.1 3.4 GO:0019343 cysteine biosynthetic process via cystathionine(GO:0019343) cysteine biosynthetic process(GO:0019344)
0.6 3.4 GO:0033600 negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
1.1 3.3 GO:0060854 patterning of lymph vessels(GO:0060854)
0.8 3.3 GO:0006867 asparagine transport(GO:0006867) glutamine transport(GO:0006868)
0.7 3.3 GO:1904721 regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) negative regulation of ribonuclease activity(GO:0060701) negative regulation of endoribonuclease activity(GO:0060702) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
1.1 3.2 GO:0032918 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
0.2 2.8 GO:0072010 renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.4 2.5 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.4 2.1 GO:0046601 positive regulation of centriole replication(GO:0046601)
0.3 2.0 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0 1.8 GO:0001837 epithelial to mesenchymal transition(GO:0001837)
0.0 1.8 GO:0000086 G2/M transition of mitotic cell cycle(GO:0000086)
0.6 1.7 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.2 1.7 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.2 1.7 GO:0060012 synaptic transmission, glycinergic(GO:0060012)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.6 18.5 GO:0034366 spherical high-density lipoprotein particle(GO:0034366) neurofibrillary tangle(GO:0097418)
0.1 7.0 GO:0055037 recycling endosome(GO:0055037)
0.0 6.1 GO:0005667 transcription factor complex(GO:0005667)
0.0 5.0 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 4.2 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.3 2.1 GO:0098536 deuterosome(GO:0098536)
0.1 2.1 GO:0005614 interstitial matrix(GO:0005614)
0.0 1.8 GO:0016459 myosin complex(GO:0016459)
0.0 1.8 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.2 1.7 GO:0000813 ESCRT I complex(GO:0000813)
0.0 1.7 GO:0034707 chloride channel complex(GO:0034707)
0.0 1.6 GO:0043195 terminal bouton(GO:0043195)
0.2 1.4 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 1.4 GO:0005769 early endosome(GO:0005769)
0.0 1.4 GO:0016328 lateral plasma membrane(GO:0016328)
0.2 1.1 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 1.1 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 1.1 GO:0036126 sperm flagellum(GO:0036126)
0.1 1.0 GO:0031091 platelet alpha granule(GO:0031091)
0.1 1.0 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 18.5 GO:0051787 misfolded protein binding(GO:0051787)
0.1 6.0 GO:0008565 protein transporter activity(GO:0008565)
0.3 5.4 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 4.3 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.6 3.9 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
1.1 3.4 GO:0098809 nitrite reductase activity(GO:0098809)
0.7 3.3 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.7 3.3 GO:0015186 L-asparagine transmembrane transporter activity(GO:0015182) L-glutamine transmembrane transporter activity(GO:0015186)
0.4 3.3 GO:0001224 RNA polymerase II transcription cofactor binding(GO:0001224)
1.1 3.2 GO:0004145 diamine N-acetyltransferase activity(GO:0004145)
0.3 2.5 GO:0005451 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.7 2.0 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.6 1.8 GO:0043912 D-lysine oxidase activity(GO:0043912)
0.0 1.8 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.6 1.7 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.1 1.7 GO:0070064 proline-rich region binding(GO:0070064)
0.0 1.7 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.5 1.6 GO:0070052 collagen V binding(GO:0070052)
0.4 1.6 GO:0004074 biliverdin reductase activity(GO:0004074)
0.0 1.6 GO:0005179 hormone activity(GO:0005179)