Motif ID: Hmbox1

Z-value: 0.810


Transcription factors associated with Hmbox1:

Gene SymbolEntrez IDGene Name
Hmbox1 ENSMUSG00000021972.8 Hmbox1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hmbox1mm10_v2_chr14_-_64949838_64949886-0.212.4e-01Click!


Activity profile for motif Hmbox1.

activity profile for motif Hmbox1


Sorted Z-values histogram for motif Hmbox1

Sorted Z-values for motif Hmbox1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hmbox1

PNG image of the network

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Top targets:


Showing 1 to 20 of 137 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_5390387 10.074 ENSMUST00000183358.1
 Asb4
ankyrin repeat and SOCS box-containing 4
chr6_-_23248264 9.202 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr13_-_3893556 2.402 ENSMUST00000099946.4
 Net1
neuroepithelial cell transforming gene 1
chr3_-_100969644 1.922 ENSMUST00000076941.5
 Ttf2
transcription termination factor, RNA polymerase II
chrX_+_159303266 1.693 ENSMUST00000112491.1
 Rps6ka3
ribosomal protein S6 kinase polypeptide 3
chr11_-_94507337 1.690 ENSMUST00000040692.8
 Mycbpap
MYCBP associated protein
chrX_+_169685191 1.634 ENSMUST00000112104.1
ENSMUST00000112107.1
 Mid1

midline 1

chr2_-_172043466 1.619 ENSMUST00000087950.3
 Cbln4
cerebellin 4 precursor protein
chr10_+_39133981 1.544 ENSMUST00000019991.7
 Tube1
epsilon-tubulin 1
chr10_+_22158566 1.474 ENSMUST00000181645.1
ENSMUST00000105522.2
 Raet1e
H60b
retinoic acid early transcript 1E
histocompatibility 60b
chr4_+_128993224 1.398 ENSMUST00000030583.6
ENSMUST00000102604.4
 Ak2

adenylate kinase 2

chrX_+_100625737 1.384 ENSMUST00000048962.3
 Kif4
kinesin family member 4
chr1_-_163289214 1.380 ENSMUST00000183691.1
 Prrx1
paired related homeobox 1
chr19_-_4928241 1.328 ENSMUST00000025851.3
 Dpp3
dipeptidylpeptidase 3
chr7_-_25788635 1.279 ENSMUST00000002677.4
ENSMUST00000085948.4
 Axl

AXL receptor tyrosine kinase

chr15_+_25773985 1.131 ENSMUST00000125667.1
 Myo10
myosin X
chr10_+_11609256 1.125 ENSMUST00000052902.7
 Gm9797
predicted pseudogene 9797
chr6_+_29853746 1.105 ENSMUST00000064872.6
ENSMUST00000152581.1
ENSMUST00000176265.1
ENSMUST00000154079.1
 Ahcyl2



S-adenosylhomocysteine hydrolase-like 2



chr1_-_152386675 1.094 ENSMUST00000015124.8
 Tsen15
tRNA splicing endonuclease 15 homolog (S. cerevisiae)
chr2_-_25224653 1.059 ENSMUST00000043584.4
 Tubb4b
tubulin, beta 4B class IVB

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 10.1 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
1.5 9.2 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.2 2.4 GO:0051451 myoblast migration(GO:0051451)
0.1 2.3 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.1 1.9 GO:0006353 DNA-templated transcription, termination(GO:0006353)
0.0 1.7 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.1 1.6 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.1 1.5 GO:0001913 T cell mediated cytotoxicity(GO:0001913)
0.0 1.5 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.2 1.4 GO:0006172 ADP biosynthetic process(GO:0006172)
0.2 1.4 GO:0000022 mitotic spindle elongation(GO:0000022) mitotic spindle midzone assembly(GO:0051256)
0.1 1.4 GO:0048664 neuron fate determination(GO:0048664)
0.3 1.3 GO:2000668 dendritic cell apoptotic process(GO:0097048) regulation of dendritic cell apoptotic process(GO:2000668)
0.1 1.3 GO:2000381 negative regulation of mesoderm development(GO:2000381)
0.1 1.1 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.1 1.0 GO:0032981 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 1.0 GO:1900181 negative regulation of protein localization to nucleus(GO:1900181)
0.1 0.9 GO:0007343 egg activation(GO:0007343)
0.1 0.8 GO:0090435 protein localization to nuclear envelope(GO:0090435)
0.0 0.8 GO:0043248 proteasome assembly(GO:0043248)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.5 10.1 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 2.8 GO:0030496 midbody(GO:0030496)
0.5 1.5 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.3 1.4 GO:0097226 sperm mitochondrial sheath(GO:0097226)
0.1 1.3 GO:0043657 host(GO:0018995) host cell part(GO:0033643) host cell(GO:0043657)
0.0 1.2 GO:0016459 myosin complex(GO:0016459)
0.1 1.1 GO:0045298 tubulin complex(GO:0045298)
0.0 0.9 GO:0034707 chloride channel complex(GO:0034707)
0.1 0.7 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.7 GO:0031519 PcG protein complex(GO:0031519)
0.1 0.6 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.1 0.6 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 0.6 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.6 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.6 GO:0005838 proteasome regulatory particle(GO:0005838)
0.0 0.6 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 0.6 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 0.5 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.1 0.5 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.5 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.4 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 8.2 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 2.6 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1 2.4 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 2.3 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.3 1.6 GO:0000213 tRNA-intron endonuclease activity(GO:0000213) endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.2 1.5 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.1 1.4 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 1.4 GO:0071837 HMG box domain binding(GO:0071837)
0.2 1.3 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 1.3 GO:0032036 myosin heavy chain binding(GO:0032036)
0.2 1.1 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 1.1 GO:0030507 spectrin binding(GO:0030507)
0.0 1.0 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.8 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.7 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.7 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.6 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.6 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 0.6 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)