Motif ID: Hmga1

Z-value: 0.838


Transcription factors associated with Hmga1:

Gene SymbolEntrez IDGene Name
Hmga1 ENSMUSG00000046711.9 Hmga1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hmga1mm10_v2_chr17_+_27556641_27556658-0.611.5e-04Click!


Activity profile for motif Hmga1.

activity profile for motif Hmga1


Sorted Z-values histogram for motif Hmga1

Sorted Z-values for motif Hmga1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hmga1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_20665250 7.290 ENSMUST00000075312.3
 Ttr
transthyretin
chr18_-_43059418 3.938 ENSMUST00000025377.7
 Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr13_-_84064772 3.709 ENSMUST00000182477.1
 Gm17750
predicted gene, 17750
chr12_-_41485751 3.398 ENSMUST00000043884.4
 Lrrn3
leucine rich repeat protein 3, neuronal
chrX_+_166344692 3.261 ENSMUST00000112223.1
ENSMUST00000112224.1
ENSMUST00000112229.2
ENSMUST00000112228.1
ENSMUST00000112227.2
ENSMUST00000112226.2
 Gpm6b





glycoprotein m6b





chr16_-_36784924 2.949 ENSMUST00000168279.1
ENSMUST00000164579.1
ENSMUST00000023616.2
 Slc15a2


solute carrier family 15 (H+/peptide transporter), member 2


chr17_+_3397189 2.667 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr18_+_37504264 2.553 ENSMUST00000052179.6
 Pcdhb20
protocadherin beta 20
chr1_+_17145357 2.350 ENSMUST00000026879.7
 Gdap1
ganglioside-induced differentiation-associated-protein 1
chr3_-_121171678 2.228 ENSMUST00000170781.1
ENSMUST00000039761.5
ENSMUST00000106467.1
ENSMUST00000106466.3
ENSMUST00000164925.2
 Rwdd3




RWD domain containing 3




chr12_-_108003594 2.209 ENSMUST00000066060.4
 Bcl11b
B cell leukemia/lymphoma 11B
chr3_+_28263205 2.082 ENSMUST00000159236.2
 Tnik
TRAF2 and NCK interacting kinase
chr10_+_4611971 2.057 ENSMUST00000105590.1
ENSMUST00000067086.7
 Esr1

estrogen receptor 1 (alpha)

chr8_+_93810832 2.025 ENSMUST00000034198.8
ENSMUST00000125716.1
 Gnao1

guanine nucleotide binding protein, alpha O

chr3_+_76593550 1.905 ENSMUST00000162471.1
 Fstl5
follistatin-like 5
chr12_+_52699297 1.896 ENSMUST00000095737.3
 Akap6
A kinase (PRKA) anchor protein 6
chr1_+_180101144 1.878 ENSMUST00000133890.1
 Cdc42bpa
CDC42 binding protein kinase alpha
chr4_+_49059256 1.854 ENSMUST00000076670.2
 E130309F12Rik
RIKEN cDNA E130309F12 gene
chr18_-_22850738 1.817 ENSMUST00000092015.4
ENSMUST00000069215.6
 Nol4

nucleolar protein 4

chr1_-_126830632 1.679 ENSMUST00000112583.1
ENSMUST00000094609.3
 Nckap5

NCK-associated protein 5


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 112 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 7.3 GO:0070327 thyroid hormone transport(GO:0070327)
0.2 4.6 GO:0007097 nuclear migration(GO:0007097)
0.6 3.9 GO:0034047 regulation of protein phosphatase type 2A activity(GO:0034047)
0.5 3.3 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.1 3.3 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.7 2.9 GO:0042938 dipeptide transport(GO:0042938)
0.4 2.5 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.8 2.4 GO:0007525 somatic muscle development(GO:0007525)
0.1 2.4 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.1 2.3 GO:0000266 mitochondrial fission(GO:0000266)
0.7 2.2 GO:1902071 positive regulation of cellular response to hypoxia(GO:1900039) regulation of hypoxia-inducible factor-1alpha signaling pathway(GO:1902071)
0.4 2.2 GO:0021773 striatal medium spiny neuron differentiation(GO:0021773)
0.2 2.2 GO:0071420 cellular response to histamine(GO:0071420)
0.5 2.1 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.4 2.1 GO:0007256 activation of JNKK activity(GO:0007256)
0.3 2.1 GO:0016584 nucleosome positioning(GO:0016584)
0.7 2.0 GO:0021852 pyramidal neuron migration(GO:0021852)
0.1 2.0 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.5 1.9 GO:0032512 regulation of protein phosphatase type 2B activity(GO:0032512) positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.0 1.9 GO:0007416 synapse assembly(GO:0007416)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.3 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.3 5.5 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 4.1 GO:0060077 inhibitory synapse(GO:0060077)
0.2 3.4 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 3.0 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 2.8 GO:0042641 actomyosin(GO:0042641)
0.1 2.2 GO:0071565 nBAF complex(GO:0071565)
0.1 2.2 GO:0030131 clathrin adaptor complex(GO:0030131)
0.1 1.9 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 1.7 GO:0005770 late endosome(GO:0005770)
0.2 1.5 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.2 1.5 GO:0000805 X chromosome(GO:0000805)
0.0 1.5 GO:0030117 membrane coat(GO:0030117) coated membrane(GO:0048475)
0.0 1.4 GO:0031901 early endosome membrane(GO:0031901)
0.0 1.4 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.0 1.2 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 1.1 GO:0044316 cone cell pedicle(GO:0044316)
0.0 1.1 GO:0030315 T-tubule(GO:0030315)
0.0 1.1 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 1.1 GO:0000786 nucleosome(GO:0000786)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 72 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 7.3 GO:0070324 thyroid hormone binding(GO:0070324)
0.0 4.3 GO:0000287 magnesium ion binding(GO:0000287)
0.3 3.7 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.0 3.0 GO:0005057 receptor signaling protein activity(GO:0005057)
0.6 2.9 GO:0042895 antibiotic transporter activity(GO:0042895)
0.2 2.5 GO:0038191 neuropilin binding(GO:0038191)
0.1 2.3 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 2.2 GO:0004890 GABA-A receptor activity(GO:0004890)
0.7 2.1 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.0 2.1 GO:0017080 sodium channel regulator activity(GO:0017080)
0.3 2.0 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.2 1.9 GO:0043495 protein anchor(GO:0043495)
0.2 1.8 GO:0001618 virus receptor activity(GO:0001618)
0.0 1.8 GO:0017124 SH3 domain binding(GO:0017124)
0.1 1.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.4 1.6 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 1.6 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.4 1.5 GO:0004515 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.2 1.5 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 1.4 GO:0005242 inward rectifier potassium channel activity(GO:0005242)