Motif ID: Hmx1

Z-value: 1.358


Transcription factors associated with Hmx1:

Gene SymbolEntrez IDGene Name
Hmx1 ENSMUSG00000067438.3 Hmx1



Activity profile for motif Hmx1.

activity profile for motif Hmx1


Sorted Z-values histogram for motif Hmx1

Sorted Z-values for motif Hmx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hmx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_147186389 15.060 ENSMUST00000109970.3
ENSMUST00000067075.5
 Nkx2-2

NK2 homeobox 2

chr12_+_109459843 7.342 ENSMUST00000173812.1
 Dlk1
delta-like 1 homolog (Drosophila)
chr7_-_144939823 7.092 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr17_-_71310952 7.048 ENSMUST00000024849.9
 Emilin2
elastin microfibril interfacer 2
chr19_-_42202150 6.459 ENSMUST00000018966.7
 Sfrp5
secreted frizzled-related sequence protein 5
chr6_+_30738044 6.322 ENSMUST00000128398.1
ENSMUST00000163949.2
ENSMUST00000124665.1
 Mest


mesoderm specific transcript


chr11_+_69965396 6.153 ENSMUST00000018713.6
 Cldn7
claudin 7
chr7_-_48881032 5.329 ENSMUST00000058745.8
 E2f8
E2F transcription factor 8
chr2_+_168081004 5.118 ENSMUST00000052125.6
 Pard6b
par-6 (partitioning defective 6) homolog beta (C. elegans)
chr18_+_74442551 4.833 ENSMUST00000121875.1
 Myo5b
myosin VB
chr2_-_92370999 4.776 ENSMUST00000176810.1
ENSMUST00000090582.4
 Gyltl1b

glycosyltransferase-like 1B

chr14_+_103070216 4.768 ENSMUST00000022721.6
 Cln5
ceroid-lipofuscinosis, neuronal 5
chr10_-_127666673 4.638 ENSMUST00000026469.2
 Nab2
Ngfi-A binding protein 2
chr10_-_127666598 4.617 ENSMUST00000099157.3
 Nab2
Ngfi-A binding protein 2
chr17_+_86963279 4.289 ENSMUST00000139344.1
 Rhoq
ras homolog gene family, member Q
chr2_+_25395866 4.206 ENSMUST00000028328.2
 Entpd2
ectonucleoside triphosphate diphosphohydrolase 2
chr7_-_116308241 4.088 ENSMUST00000183057.1
ENSMUST00000182487.1
ENSMUST00000181998.1
 Plekha7


pleckstrin homology domain containing, family A member 7


chr1_+_135729147 4.084 ENSMUST00000027677.7
 Csrp1
cysteine and glycine-rich protein 1
chr2_-_92371039 4.052 ENSMUST00000068586.6
 Gyltl1b
glycosyltransferase-like 1B
chr6_-_95718800 4.033 ENSMUST00000079847.5
 Suclg2
succinate-Coenzyme A ligase, GDP-forming, beta subunit

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 130 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.0 15.1 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.9 12.7 GO:0035269 protein O-linked mannosylation(GO:0035269)
1.3 9.3 GO:0016480 negative regulation of transcription from RNA polymerase III promoter(GO:0016480)
2.0 7.9 GO:0032439 endosome localization(GO:0032439)
0.2 7.3 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.7 7.2 GO:0007042 lysosomal lumen acidification(GO:0007042)
1.0 7.1 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
2.2 6.5 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.4 6.2 GO:0032463 negative regulation of protein homooligomerization(GO:0032463)
0.3 5.9 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.2 5.7 GO:0010883 regulation of lipid storage(GO:0010883)
1.8 5.3 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
0.3 4.9 GO:0033327 Leydig cell differentiation(GO:0033327)
0.2 4.3 GO:0090005 negative regulation of establishment of protein localization to plasma membrane(GO:0090005)
0.5 4.2 GO:0009181 purine nucleoside diphosphate catabolic process(GO:0009137) purine ribonucleoside diphosphate catabolic process(GO:0009181)
1.0 4.1 GO:0072385 minus-end-directed organelle transport along microtubule(GO:0072385)
0.7 4.1 GO:0045218 zonula adherens maintenance(GO:0045218)
0.1 4.1 GO:0070527 platelet aggregation(GO:0070527)
0.4 4.0 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.3 4.0 GO:0060707 trophoblast giant cell differentiation(GO:0060707)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 16.5 GO:0005794 Golgi apparatus(GO:0005794)
0.0 15.8 GO:0005667 transcription factor complex(GO:0005667)
0.2 12.2 GO:0005581 collagen trimer(GO:0005581)
0.2 10.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 10.4 GO:0009897 external side of plasma membrane(GO:0009897)
1.3 7.9 GO:0045179 apical cortex(GO:0045179)
0.1 5.5 GO:0016528 sarcoplasm(GO:0016528)
0.1 5.4 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 5.1 GO:0016324 apical plasma membrane(GO:0016324)
0.6 4.8 GO:0005775 vacuolar lumen(GO:0005775)
0.1 4.4 GO:0001750 photoreceptor outer segment(GO:0001750)
0.2 4.2 GO:0005605 basal lamina(GO:0005605)
0.4 4.1 GO:0005915 zonula adherens(GO:0005915)
0.3 4.1 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 4.1 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.7 4.0 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.3 3.7 GO:0005922 connexon complex(GO:0005922)
0.3 3.5 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 3.5 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 3.3 GO:0005925 focal adhesion(GO:0005925)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 99 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 17.9 GO:0008134 transcription factor binding(GO:0008134)
0.3 15.1 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 14.9 GO:0005198 structural molecule activity(GO:0005198)
2.5 12.7 GO:0018121 imidazoleglycerol-phosphate synthase activity(GO:0000107) NAD(P)-cysteine ADP-ribosyltransferase activity(GO:0018071) NAD(P)-asparagine ADP-ribosyltransferase activity(GO:0018121) NAD(P)-serine ADP-ribosyltransferase activity(GO:0018127) 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity(GO:0043867) purine deoxyribosyltransferase activity(GO:0044102)
0.0 9.8 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 8.7 GO:0001047 core promoter binding(GO:0001047)
0.2 8.5 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.3 7.1 GO:0070064 proline-rich region binding(GO:0070064)
0.3 6.5 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.4 6.4 GO:0005537 mannose binding(GO:0005537)
0.1 6.1 GO:0003777 microtubule motor activity(GO:0003777)
0.0 6.1 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 5.7 GO:0005509 calcium ion binding(GO:0005509)
0.0 5.2 GO:0051015 actin filament binding(GO:0051015)
0.2 4.7 GO:0030506 ankyrin binding(GO:0030506)
0.1 4.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.3 4.3 GO:0005522 profilin binding(GO:0005522)
0.5 4.2 GO:0043262 adenosine-diphosphatase activity(GO:0043262)
0.2 4.2 GO:0043236 laminin binding(GO:0043236)
1.0 4.1 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)