Motif ID: Hmx2

Z-value: 0.480


Transcription factors associated with Hmx2:

Gene SymbolEntrez IDGene Name
Hmx2 ENSMUSG00000050100.7 Hmx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hmx2mm10_v2_chr7_+_131548755_131548773-0.096.3e-01Click!


Activity profile for motif Hmx2.

activity profile for motif Hmx2


Sorted Z-values histogram for motif Hmx2

Sorted Z-values for motif Hmx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hmx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 127 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_48667508 2.849 ENSMUST00000144465.1
ENSMUST00000133479.1
ENSMUST00000119070.1
ENSMUST00000152018.1
 Otx2



orthodenticle homolog 2 (Drosophila)



chr5_-_28467093 2.579 ENSMUST00000002708.3
 Shh
sonic hedgehog
chr12_+_117843873 2.311 ENSMUST00000176735.1
ENSMUST00000177339.1
 Cdca7l

cell division cycle associated 7 like

chr18_+_50051702 1.997 ENSMUST00000134348.1
ENSMUST00000153873.2
 Tnfaip8

tumor necrosis factor, alpha-induced protein 8

chr13_-_92794809 1.687 ENSMUST00000022213.7
 Thbs4
thrombospondin 4
chr2_-_24048857 1.629 ENSMUST00000114497.1
 Hnmt
histamine N-methyltransferase
chr4_+_99955715 1.428 ENSMUST00000102783.4
 Pgm2
phosphoglucomutase 2
chr18_-_65939048 1.402 ENSMUST00000025396.3
 Rax
retina and anterior neural fold homeobox
chr4_-_62470868 1.347 ENSMUST00000135811.1
ENSMUST00000120095.1
ENSMUST00000030087.7
ENSMUST00000107452.1
ENSMUST00000155522.1
 Wdr31




WD repeat domain 31




chr6_+_29694204 1.305 ENSMUST00000046750.7
ENSMUST00000115250.3
 Tspan33

tetraspanin 33

chr2_-_24049389 1.197 ENSMUST00000051416.5
 Hnmt
histamine N-methyltransferase
chr18_+_4993795 1.193 ENSMUST00000153016.1
 Svil
supervillin
chr14_+_73237891 1.145 ENSMUST00000044405.6
 Lpar6
lysophosphatidic acid receptor 6
chr11_-_100822525 1.110 ENSMUST00000107358.2
 Stat5b
signal transducer and activator of transcription 5B
chr13_-_71963713 1.056 ENSMUST00000077337.8
 Irx1
Iroquois related homeobox 1 (Drosophila)
chr5_+_23850590 1.016 ENSMUST00000181574.1
 2700038G22Rik
RIKEN cDNA 2700038G22 gene
chr18_-_66022580 0.965 ENSMUST00000143990.1
 Lman1
lectin, mannose-binding, 1
chr18_-_34579072 0.829 ENSMUST00000079287.5
 Nme5
NME/NM23 family member 5
chr1_+_91298354 0.828 ENSMUST00000142488.1
ENSMUST00000124832.1
ENSMUST00000147523.1
 Scly


selenocysteine lyase


chr3_-_65392546 0.808 ENSMUST00000119896.1
 Ssr3
signal sequence receptor, gamma

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 2.8 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.0 2.8 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.9 2.6 GO:0060769 positive regulation of epithelial cell proliferation involved in prostate gland development(GO:0060769) kidney smooth muscle tissue development(GO:0072194) negative regulation of dopaminergic neuron differentiation(GO:1904339)
0.0 2.0 GO:0032611 interleukin-1 beta production(GO:0032611)
0.6 1.7 GO:0071603 endothelial cell-cell adhesion(GO:0071603)
0.2 1.6 GO:0001887 selenium compound metabolic process(GO:0001887)
0.1 1.5 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.1 1.4 GO:0021854 hypothalamus development(GO:0021854)
0.0 1.3 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.4 1.1 GO:0046544 regulation of natural killer cell proliferation(GO:0032817) positive regulation of natural killer cell proliferation(GO:0032819) development of secondary male sexual characteristics(GO:0046544)
0.2 1.0 GO:0008611 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) cellular lipid biosynthetic process(GO:0097384) ether biosynthetic process(GO:1901503)
0.3 0.9 GO:0048014 Tie signaling pathway(GO:0048014)
0.3 0.8 GO:0015889 cobalamin transport(GO:0015889)
0.1 0.8 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1 0.8 GO:0046036 GTP biosynthetic process(GO:0006183) CTP biosynthetic process(GO:0006241) CTP metabolic process(GO:0046036)
0.2 0.7 GO:0045472 response to ether(GO:0045472)
0.1 0.7 GO:0006528 asparagine metabolic process(GO:0006528)
0.0 0.7 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.7 GO:0046688 response to copper ion(GO:0046688)
0.0 0.7 GO:0007029 endoplasmic reticulum organization(GO:0007029)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.6 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 1.7 GO:0005604 basement membrane(GO:0005604)
0.2 1.3 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 1.2 GO:0043034 costamere(GO:0043034)
0.0 1.2 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 1.0 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 1.0 GO:0033655 host cell cytoplasm(GO:0030430) host cell cytoplasm part(GO:0033655)
0.0 1.0 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.9 GO:0005902 microvillus(GO:0005902)
0.3 0.8 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.0 0.8 GO:0031225 anchored component of membrane(GO:0031225)
0.2 0.7 GO:0042585 germinal vesicle(GO:0042585)
0.1 0.7 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.1 0.7 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.7 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 0.6 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.6 GO:0001772 immunological synapse(GO:0001772)
0.1 0.5 GO:0005638 lamin filament(GO:0005638)
0.1 0.4 GO:0036156 inner dynein arm(GO:0036156)
0.1 0.4 GO:0097487 multivesicular body, internal vesicle(GO:0097487)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.6 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.6 4.3 GO:0043237 laminin-1 binding(GO:0043237)
0.0 2.8 GO:0008170 N-methyltransferase activity(GO:0008170)
0.0 2.0 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.2 1.6 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.3 1.4 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 1.1 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.2 1.0 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.1 1.0 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.1 1.0 GO:0005537 mannose binding(GO:0005537)
0.1 0.8 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.1 0.8 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.8 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.1 0.7 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 0.7 GO:0042609 CD4 receptor binding(GO:0042609)
0.1 0.7 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.7 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.7 GO:0050694 galactose 3-O-sulfotransferase activity(GO:0050694)
0.1 0.6 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 0.6 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)