Motif ID: Hoxa11_Hoxc12

Z-value: 1.080

Transcription factors associated with Hoxa11_Hoxc12:

Gene SymbolEntrez IDGene Name
Hoxa11 ENSMUSG00000038210.9 Hoxa11
Hoxc12 ENSMUSG00000050328.2 Hoxc12



Activity profile for motif Hoxa11_Hoxc12.

activity profile for motif Hoxa11_Hoxc12


Sorted Z-values histogram for motif Hoxa11_Hoxc12

Sorted Z-values for motif Hoxa11_Hoxc12



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa11_Hoxc12

PNG image of the network

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Top targets:


Showing 1 to 20 of 115 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_35076902 11.721 ENSMUST00000172494.1
ENSMUST00000172678.1
ENSMUST00000013910.4
 Ly6g6e


lymphocyte antigen 6 complex, locus G6E


chr1_-_56978534 7.870 ENSMUST00000177282.1
 Satb2
special AT-rich sequence binding protein 2
chr6_-_55681257 5.806 ENSMUST00000044767.8
 Neurod6
neurogenic differentiation 6
chr1_+_178529113 5.544 ENSMUST00000161017.1
 Kif26b
kinesin family member 26B
chr1_+_43730593 5.248 ENSMUST00000027217.8
 1500015O10Rik
RIKEN cDNA 1500015O10 gene
chr2_+_28205648 5.116 ENSMUST00000102879.3
ENSMUST00000028177.4
 Olfm1

olfactomedin 1

chr14_+_80000292 4.047 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr16_-_57231434 3.728 ENSMUST00000023431.6
 Tbc1d23
TBC1 domain family, member 23
chr14_+_27622433 3.316 ENSMUST00000090302.5
 Erc2
ELKS/RAB6-interacting/CAST family member 2
chr15_-_43869993 3.280 ENSMUST00000067469.4
 Tmem74
transmembrane protein 74
chr18_+_69346143 3.130 ENSMUST00000114980.1
 Tcf4
transcription factor 4
chr6_+_108213086 3.032 ENSMUST00000032192.6
 Itpr1
inositol 1,4,5-trisphosphate receptor 1
chr9_-_55919605 3.006 ENSMUST00000037408.8
 Scaper
S phase cyclin A-associated protein in the ER
chr17_+_8283762 2.981 ENSMUST00000155364.1
ENSMUST00000046754.8
ENSMUST00000124023.1
 Mpc1


mitochondrial pyruvate carrier 1


chr17_+_6270475 2.960 ENSMUST00000088940.4
 Tmem181a
transmembrane protein 181A
chr16_-_45408955 2.882 ENSMUST00000163230.1
 Cd200
CD200 antigen
chr2_+_23068168 2.797 ENSMUST00000028121.7
ENSMUST00000114523.2
ENSMUST00000144088.1
 Acbd5


acyl-Coenzyme A binding domain containing 5


chr13_+_16014457 2.773 ENSMUST00000164993.1
 Inhba
inhibin beta-A
chr16_-_74411776 2.653 ENSMUST00000116586.2
 Robo2
roundabout homolog 2 (Drosophila)
chr18_-_43393346 2.578 ENSMUST00000025379.7
 Dpysl3
dihydropyrimidinase-like 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 11.7 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.5 7.9 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.1 7.1 GO:0098792 xenophagy(GO:0098792)
0.3 5.8 GO:0021542 dentate gyrus development(GO:0021542)
1.8 5.5 GO:0072092 ureteric bud invasion(GO:0072092)
0.7 5.2 GO:0070314 G1 to G0 transition(GO:0070314)
0.5 5.1 GO:0023041 neuronal signal transduction(GO:0023041)
0.1 4.0 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1 3.7 GO:0032755 positive regulation of interleukin-6 production(GO:0032755)
0.3 3.1 GO:0042118 endothelial cell activation(GO:0042118)
1.0 3.0 GO:0009405 pathogenesis(GO:0009405)
0.7 3.0 GO:1901475 pyruvate transmembrane transport(GO:1901475)
0.5 3.0 GO:0042045 epithelial fluid transport(GO:0042045)
0.1 2.9 GO:0043030 regulation of macrophage activation(GO:0043030)
0.6 2.8 GO:0030242 pexophagy(GO:0030242)
0.6 2.8 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.1 2.8 GO:0001919 regulation of receptor recycling(GO:0001919)
0.9 2.7 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.2 2.6 GO:0051764 actin crosslink formation(GO:0051764)
0.3 2.5 GO:0030035 microspike assembly(GO:0030035)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.9 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 9.7 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 5.1 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 4.3 GO:0005871 kinesin complex(GO:0005871)
0.3 4.0 GO:0042581 specific granule(GO:0042581)
0.1 3.3 GO:0048786 presynaptic active zone(GO:0048786)
1.0 3.0 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 2.9 GO:0005913 cell-cell adherens junction(GO:0005913)
0.9 2.8 GO:0043512 inhibin A complex(GO:0043512)
0.3 2.8 GO:0043083 synaptic cleft(GO:0043083)
0.0 2.8 GO:0032587 ruffle membrane(GO:0032587)
0.1 2.7 GO:0030673 axolemma(GO:0030673)
0.1 2.6 GO:0031941 filamentous actin(GO:0031941)
0.0 2.6 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 2.5 GO:0030175 filopodium(GO:0030175)
0.6 1.8 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.1 1.4 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.3 1.3 GO:0031084 BLOC-2 complex(GO:0031084)
0.1 1.0 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 1.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.9 11.7 GO:0030549 acetylcholine receptor activator activity(GO:0030549)
0.0 6.1 GO:0003682 chromatin binding(GO:0003682)
0.4 5.5 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 5.1 GO:0001540 beta-amyloid binding(GO:0001540)
0.1 4.0 GO:0045296 cadherin binding(GO:0045296)
0.0 3.8 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 3.5 GO:0030165 PDZ domain binding(GO:0030165)
0.0 3.4 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.8 3.1 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
1.0 3.0 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.7 3.0 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.3 3.0 GO:0015643 toxic substance binding(GO:0015643)
0.2 3.0 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.0 2.9 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.5 2.8 GO:0070699 type II activin receptor binding(GO:0070699)
0.4 2.8 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 2.8 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.3 2.7 GO:0008046 axon guidance receptor activity(GO:0008046)
0.6 2.6 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.1 2.6 GO:0000062 fatty-acyl-CoA binding(GO:0000062)